4.7 Article

Optimized integration of metabolomics and lipidomics reveals brain region-specific changes of oxidative stress and neuroinflammation in type 1 diabetic mice with cognitive decline

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Region-specific metabolic characterization of the type 1 diabetic brain in mice with and without cognitive impairment

Pengtao Xu et al.

Summary: Metabolic alterations in specific brain regions of T1D mice may serve as potential biomarkers for early diagnosis and monitoring of diabetic cognitive decline.

NEUROCHEMISTRY INTERNATIONAL (2021)

Article Biochemistry & Molecular Biology

NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer?s diseases

Min Woo Park et al.

Summary: The study found elevated levels of NOX4 protein in impaired astrocytes of AD patients and mouse AD models, leading to oxidative stress and ferroptosis. Overexpression of NOX4 resulted in impaired mitochondrial metabolism and oxidative stress, increasing ferroptosis in astrocytes.

REDOX BIOLOGY (2021)

Review Food Science & Technology

Glutamate - A multifaceted molecule: Endogenous neurotransmitter, controversial food additive, design compound for anti-cancer drugs. A critical appraisal

Octavia-Laura Moldovan et al.

Summary: This article discusses the long-term toxicity of MSG and the experimental evidence that supports it. It highlights the controversy surrounding the administered doses in animal models and the potential anti-cancer effects of MSG. The need for harmonization of safe doses of MSG based on current scientific studies is also emphasized.

FOOD AND CHEMICAL TOXICOLOGY (2021)

Review Geriatrics & Gerontology

Potential Crosstalk Between Parkinson's Disease and Energy Metabolism

Meiqiu Liu et al.

Summary: Parkinson's disease is characterized by the accumulation of alpha-synuclein in the substantia nigra and the degeneration of nigrostriatal dopaminergic neurons. Studies suggest that the pathology of PD may originate from the gastrointestinal tract and progress upwards to the central nervous system, involving nuclei related to energy metabolism control. Metabolism-related peptides are implicated in the progression of PD, which is further exacerbated by abnormal glucose and lipid metabolism in patients. Exploring the correlation between PD and energy metabolism may offer potential strategies for treatment.

AGING AND DISEASE (2021)

Review Endocrinology & Metabolism

Cognitive dysfunction in diabetes: how to implement emerging guidelines

Geert J. Biessels et al.

DIABETOLOGIA (2020)

Article Biochemical Research Methods

Development of a qualitative/quantitative strategy for comprehensive determination of polar lipids by LC-MS/MS in human plasma

M. A. Lopez-Bascon et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression

Raoxu Wang et al.

JOURNAL OF GENETICS AND GENOMICS (2020)

Review Biochemistry & Molecular Biology

Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis

Melanie Graille et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

Dominic S. A. Simpson et al.

ANTIOXIDANTS (2020)

Review Multidisciplinary Sciences

Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases

Tim Bartels et al.

SCIENCE (2020)

Review Endocrinology & Metabolism

A Possible Neurodegeneration Mechanism Triggered by Diabetes

Aisan Farhadi et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)

Article Biochemistry & Molecular Biology

Type 1 diabetes induces cognitive dysfunction in rats associated with alterations of the gut microbiome and metabolomes in serum and hippocampus

Hongchang Gao et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

Meeting Abstract Clinical Neurology

Effect of agmatine on impairment of hippocampal neurogenesis and neuroinflammation in streptozotocin-induced diabetes

H. Zortul et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

HMDB 4.0: the human metabolome database for 2018

David S. Wishart et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Medicine, Research & Experimental

Disturbed purine nucleotide metabolism in chronic kidney disease is a risk factor for cognitive impairment

Muhammed Khairujjaman Mazumder et al.

MEDICAL HYPOTHESES (2018)

Review Endocrinology & Metabolism

Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications

Geert Jan Biessels et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

Review Behavioral Sciences

Frontal Cortex and the Hierarchical Control of Behavior

David Badre et al.

TRENDS IN COGNITIVE SCIENCES (2018)

Review Neurosciences

Microglia in neurodegeneration

Suzanne Hickman et al.

NATURE NEUROSCIENCE (2018)

Letter Neurosciences

Viewpoints: how the hippocampus contributes to memory, navigation and cognition

John Lisman et al.

NATURE NEUROSCIENCE (2017)

Review Pharmacology & Pharmacy

Brain injury with diabetes mellitus: evidence, mechanisms and treatment implications

Sherifa A. Hamed

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2017)

Article Medicine, General & Internal

Type 1 diabetes mellitus

Anastasia Katsarou et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Article Biochemistry & Molecular Biology

Cognitive decline in type 2 diabetic db/db mice may be associated with brain region-specific metabolic disorders

Hong Zheng et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

Article Biochemistry & Molecular Biology

Lipid peroxidation in cell death

Michael M. Gaschler et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Review Medicine, Research & Experimental

Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies

Vibha Rani et al.

LIFE SCIENCES (2016)

Article Biochemistry & Molecular Biology

Interplay between oxidant species and energy metabolism

Celia Quijano et al.

REDOX BIOLOGY (2016)

Review Spectroscopy

HILIC-MS for metabolomics: An attractive and complementary approach to RPLC-MS

Dao-Quan Tang et al.

MASS SPECTROMETRY REVIEWS (2016)

Article Biochemistry & Molecular Biology

Regulation of mammalian nucleotide metabolism and biosynthesis

Andrew N. Lane et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Neurosciences

Influence of Oxidative Stress Biomarkers on Cognitive Decline

Frederic Revel et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

Review Biochemical Research Methods

Extraction for Metabolomics: Access to The Metabolome

Mian Yahya Mushtaq et al.

PHYTOCHEMICAL ANALYSIS (2014)

Article Medicine, Research & Experimental

Methionine restriction affects oxidative stress and glutathione-related redox pathways in the rat

Sreenivasa Maddineni et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2013)

Review Biochemistry & Molecular Biology

Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

Ralph J. DeBerardinis et al.

Article Chemistry, Analytical

Expanding Coverage of the Metabolome for Global Metabolite Profiling

Oscar Yanes et al.

ANALYTICAL CHEMISTRY (2011)

Review Spectroscopy

METABOLOMIC APPLICATIONS OF HILIC-LC-MS

Simon Cubbon et al.

MASS SPECTROMETRY REVIEWS (2010)

Review Biochemistry & Molecular Biology

beta-Alanine as a small molecule neurotransmitter

K. E. Tiedje et al.

NEUROCHEMISTRY INTERNATIONAL (2010)

Article Biochemical Research Methods

High-throughput tissue extraction protocol for NMR- and MS-based metabolomics

Huifeng Wu et al.

ANALYTICAL BIOCHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Lipid peroxidation products as oxidative stress biomarkers

Etsuo Niki

BIOFACTORS (2008)

Review Endocrinology & Metabolism

Cognitive dysfunction and diabetes mellitus

Christopher T. Kodl et al.

ENDOCRINE REVIEWS (2008)

Article Biochemistry & Molecular Biology

Borrelia burgdorferi membranes are the primary targets of reactive oxygen species

Julie A. Boylan et al.

MOLECULAR MICROBIOLOGY (2008)

Editorial Material Multidisciplinary Sciences

Systems biology - Metabonomics

Jeremy K. Nicholson et al.

NATURE (2008)

Article Endocrinology & Metabolism

Evaluation of metabolite extraction strategies from tissue samples using NMR metabolomics

Ching Yu Lin et al.

METABOLOMICS (2007)

Article Multidisciplinary Sciences

Inflammation and metabolic disorders

Goekhan S. Hotamisligil

NATURE (2006)