4.6 Review

Liquid Biopsy Based Circulating Biomarkers in Metastatic Prostate Cancer

Related references

Note: Only part of the references are listed.
Article Biophysics

Biosensors for circulating tumor cells (CTCs)-biomarker detection in lung and prostate cancer: Trends and prospects

Syed Harris Hussain et al.

Summary: Analysis of circulating tumor cells (CTCs) and their associated biomarkers can provide valuable information for lung and prostate cancer, aiding in early detection and personalized treatment selection. Biosensors offer an elegant alternative to conventional methods for real-time, multiplexed analysis of cancer biomarkers at lower concentrations.

BIOSENSORS & BIOELECTRONICS (2022)

Review Urology & Nephrology

Overall Survival After Systemic Treatment in High-volume Versus Low-volume Metastatic Hormone-sensitive Prostate Cancer: Systematic Review and Network Meta-analysis

Mike Wenzel et al.

Summary: This study compared the efficacy of different drugs in patients with metastatic hormone-sensitive prostate cancer through network meta-analysis, finding that abiraterone is most effective for high-volume disease, while enzalutamide is most effective for low-volume disease.

EUROPEAN UROLOGY FOCUS (2022)

Article Cell Biology

Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression

Sujun Chen et al.

Summary: Chen et al. conducted single-cell analysis to identify transcriptomic remodeling in various cell types that regulate prostate cancer progression. They found that the tumor microenvironment displayed activation of progression-associated transcriptomic programs and identified a subset of endothelial cells that actively communicate with tumor cells, promoting cancer cell invasion. Their study also revealed promiscuous KLK3 expression and the ability of cancer cells to alter T-cell transcriptomes.

NATURE CELL BIOLOGY (2021)

Editorial Material Cell Biology

Prostate cancer hijacks the microenvironment

Phillip Thienger et al.

Summary: The study finds that prostate cancer is difficult to treat due to its molecular, cellular, and clinical heterogeneity. By uncovering unexpected transcriptomic reprogramming in immune cells and non-immune components of the tumor microenvironment, new therapeutic approaches against prostate cancer may be possible.

NATURE CELL BIOLOGY (2021)

Article Oncology

Liquid biopsy enters the clinic - implementation issues and future challenges

Michail Ignatiadis et al.

Summary: The approval of liquid biopsy assays for detecting genetic alterations in plasma cell-free DNA has marked a tipping point for the clinical use of this technology, especially in patients with advanced-stage cancer. The next frontier is likely to be the systemic treatment of patients with 'ctDNA relapse' and other potential future applications include cancer screening and diagnosis.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Oncology

Automated enumeration and phenotypic characterization of CTCs and tdEVs in patients with metastatic castration resistant prostate cancer

Steffi Oeyen et al.

Summary: Automated CTC enumeration is reliable for prognosis assessment in mCRPC patients, and studying CTC phenotypic diversity adds value to patient prognostication beyond enumeration. High CTC phenotypic diversity before treatment is associated with shorter progression-free survival and overall survival, highlighting the importance of considering this factor in patient care.

PROSTATE CANCER AND PROSTATIC DISEASES (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Pharmacology & Pharmacy

Prostate Cancer Biomarkers: From diagnosis to prognosis and precision-guided therapeutics

Maria Adamaki et al.

Summary: Prostate cancer is a highly heterogeneous disease, with therapeutic decision-making highly reliant on patient stratification and differentiation between benign and aggressive states; clinically valuable biomarkers play a crucial role in timely prevention of disease metastasis and therapy selection; challenges associated with identifying clinically significant prostate cancer biomarkers need to be addressed through possible solutions.

PHARMACOLOGY & THERAPEUTICS (2021)

Article Multidisciplinary Sciences

Cell-free DNA concentration and fragment size as a biomarker for prostate cancer

Emmalyn Chen et al.

Summary: This study investigated the potential of using cfDNA as a biomarker for detecting more advanced and aggressive prostate cancer. It found that elevated cfDNA concentration was associated with metastatic castration-resistant prostate cancer, while decreased fragment size was linked to a higher risk of localized disease. However, the sensitivity and specificity of cfDNA as a diagnostic marker for distinguishing between healthy individuals and those with localized prostate cancer remain imperfect.

SCIENTIFIC REPORTS (2021)

Review Cell Biology

Androgen-Driven Fusion Genes and Chimeric Transcripts in Prostate Cancer

Mauro Scaravilli et al.

Summary: Androgens and their receptor play crucial roles in various diseases, particularly in prostate cancer. Genetic fusions regulated by androgens are more common in prostate cancer compared to other tumors, raising questions that require further investigation.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Oncology

Expression of immune checkpoints on circulating tumor cells in men with metastatic prostate cancer

Tian Zhang et al.

Summary: The study found that CTCs from men with mPC often express B7-H3, and there is heterogeneity in the expression of immune checkpoints PD-L1, PD-L2, and CTLA-4 across different disease states. Detection of these immune checkpoints in CTCs may aid in monitoring immunotherapy efficacy.

BIOMARKER RESEARCH (2021)

Article Oncology

Measurement of the Drug Sensitivity of Single Prostate Cancer Cells

Fikri Abali et al.

Summary: The study highlights the importance of measuring protein secretion from individual cancer cells and how it can be influenced by different drugs. It shows that this method has the potential to accelerate drug development, enhance understanding of therapy resistance, and improve personalized cancer treatment.

CANCERS (2021)

Review Andrology

Extracellular vesicles in prostate cancer: a narrative review

Koji Hatano et al.

Summary: Remarkable progress has been made in prostate cancer biomarker discovery using liquid biopsies, with EVs showing potential as biomarkers for diagnosis and disease progression prediction in prostate cancer. EVs play a role in tumor microenvironment development and cancer progression.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2021)

Article Oncology

Development and validation of circulating tumour cell enumeration (Epic Sciences) as a prognostic biomarker in men with metastatic castration-resistant prostate cancer

H. I. Scher et al.

Summary: The study evaluated the prognostic significance of circulating tumor cell (CTC) number determined on the Epic Sciences platform in men with metastatic castration-resistant prostate cancer (mCRPC) treated with an androgen receptor signalling inhibitor (ARSI). The results showed a significant correlation between pre-treatment CTC number and overall survival (OS) in these patients, which was validated in an independent dataset. Additionally, a strong correlation was observed between CTC counts determined on the CellSearch and Epic platforms.

EUROPEAN JOURNAL OF CANCER (2021)

Article Oncology

Molecular Phenotyping of AR Signaling for Predicting Targeted Therapy in Castration Resistant Prostate Cancer

Agus Rizal A. H. Hamid et al.

Summary: Castration-resistant prostate cancer (CRPC) is characterized by tumor resistance to androgen deprivation therapy (ADT), with molecular changes in the AR signaling cascade explaining ADT resistance. Testing for specific molecular changes in the AR signaling pathway before treatment may lead to personalized treatment. A study evaluated molecular changes in CRPC patients and found that the majority still had an active AR signaling pathway, with heterogeneity in observed molecular changes classified into 4 major subgroups. Fresh tissue samples before starting new treatment are recommended for characterizing the AR signaling pathway in CRPC patients.

FRONTIERS IN ONCOLOGY (2021)

Review Medical Laboratory Technology

Biomarkers for prostate cancer: prostate-specific antigen and beyond

Michael J. Duffy

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2020)

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Article Medicine, Research & Experimental

Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer

Himisha Beltran et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Medicine, Research & Experimental

Epithelial-mesenchymal transition of circulating tumor cells in prostate cancer is promoted by survivin

Faying Yang et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)

Review Oncology

The role of extracellular vesicles in prostate cancer with clinical applications

Yu-Ling Tai et al.

ENDOCRINE-RELATED CANCER (2020)

Article Computer Science, Artificial Intelligence

Deep learning of circulating tumour cells

Leonie L. Zeune et al.

NATURE MACHINE INTELLIGENCE (2020)

Review Oncology

Advanced Prostate Cancer: Treatment Advances and Future Directions

Umang Swami et al.

TRENDS IN CANCER (2020)

Article Hematology

Tumor-educated platelets

Sjors G. J. G. In 't Veld et al.

BLOOD (2019)

Article Oncology

EMT Markers in Locally-Advanced Prostate Cancer: Predicting Recurrence?

Katia A. Cheaito et al.

FRONTIERS IN ONCOLOGY (2019)

Article Oncology

Targeting cathepsin K diminishes prostate cancer establishment and growth in murine bone

Weiping Liang et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2019)

Review Urology & Nephrology

Evolution of the Liquid Biopsy in Metastatic Prostate Cancer

Jose G. Moreno et al.

UROLOGY (2019)

Article Endocrinology & Metabolism

Plasma extracellular vesicles as phenotypic biomarkers in prostate cancer patients

France-Helene Joncas et al.

PROSTATE (2019)

Article Urology & Nephrology

Circulating Tumor DNA Abundance and Potential Utility in De Novo Metastatic Prostate Cancer

Gillian Vandekerkhove et al.

EUROPEAN UROLOGY (2019)

Article Medicine, Research & Experimental

Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer

Adam Sharp et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Oncology

RB1 Heterogeneity in Advanced Metastatic Castration-Resistant Prostate Cancer

Daniel Nava Rodrigues et al.

CLINICAL CANCER RESEARCH (2019)

Article Oncology

Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer

Alexander W. Wyatt et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

Article Oncology

Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer

Alexander W. Wyatt et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

Review Chemistry, Analytical

Microfluidic technologies for circulating tumor cell isolation

Hyungseok Cho et al.

ANALYST (2018)

Article Oncology

Metabolic reprogramming-based characterization of circulating tumor cells in prostate cancer

Jing Chen et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

Review Medicine, General & Internal

Metastatic Prostate Cancer

Oliver Sartor et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

IL-23 secreted by myeloid cells drives castration-resistant prostate cancer

Arianna Calcinotto et al.

NATURE (2018)

Article Multidisciplinary Sciences

Functional profiling of circulating tumor cells with an integrated vortex capture and single-cell protease activity assay

Manjima Dhar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Editorial Material Medicine, General & Internal

Prostate cancer screening with prostate-specific antigen (PSA) test: a clinical practice guideline

Kari A. O. Tikkinen et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

Review Pathology

Improving the CellSearch® system

J. F. Swennenhuis et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2016)

Article Urology & Nephrology

A Whole Blood Assay for AR-V7 and ARv567es in Patients with Prostate Cancer

Xichun Liu et al.

JOURNAL OF UROLOGY (2016)

Review Oncology

Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting

E. S. Antonarakis et al.

PROSTATE CANCER AND PROSTATIC DISEASES (2016)

Review Urology & Nephrology

Role of androgen receptor splice variants in prostate cancer metastasis

Jin Xu et al.

ASIAN JOURNAL OF UROLOGY (2016)

Article Biochemistry & Molecular Biology

The Molecular Taxonomy of Primary Prostate Cancer

Adam Abeshouse et al.

Article Urology & Nephrology

Exosomal miR-1290 and miR-375 as Prognostic Markers in Castration-resistant Prostate Cancer

Xiaoyi Huang et al.

EUROPEAN UROLOGY (2015)

Article Biochemical Research Methods

Self-seeding microwell chip for the isolation and characterization of single cells

Joost F. Swennenhuis et al.

LAB ON A CHIP (2015)

Review Genetics & Heredity

Landscape of gene fusions in epithelial cancers: seq and ye shall find

Chandan Kumar-Sinha et al.

GENOME MEDICINE (2015)

Review Urology & Nephrology

The Prostate Health Index: a new test for the detection of prostate cancer

Stacy Loeb et al.

THERAPEUTIC ADVANCES IN UROLOGY (2014)

Review Medical Laboratory Technology

Evaluation of [-2] proPSA and Prostate Health Index (phi) for the detection of prostate cancer: a systematic review and meta-analysis

Xavier Filella et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2013)

Review Pharmacology & Pharmacy

Androgen receptors in hormone-dependent and castration-resistant prostate cancer

Ayesha A. Shafi et al.

PHARMACOLOGY & THERAPEUTICS (2013)

Review Cell Biology

Beyond PSA: The Next Generation of Prostate Cancer Biomarkers

John R. Prensner et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

Article Urology & Nephrology

Biology of Castration-Recurrent Prostate Cancer

Faris Azzouni et al.

UROLOGIC CLINICS OF NORTH AMERICA (2012)

Review Biochemistry & Molecular Biology

Non-genetic cell-to-cell variability and the consequences for pharmacology

Mario Niepel et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2009)

Editorial Material Medicine, General & Internal

Screening for prostate cancer remains controversial

David E. Neal et al.

LANCET (2009)

Review Oncology

Circulating tumour cell detection on its way to routine diagnostic implementation?

Stefan Sleijfer et al.

EUROPEAN JOURNAL OF CANCER (2007)

Article Medicine, General & Internal

Circulating tumor cells, disease progression, and survival in metastatic breast cancer

M Cristofanilli et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)