4.6 Review

Molecular Detection Methods in HPV-Related Cancers

Related references

Note: Only part of the references are listed.
Review Medicine, Research & Experimental

HPV-Related Multiphenotypic Sinonasal Carcinoma: A Case Report and Literature Review

Matthew L. Ward et al.

Summary: The study focused on human papilloma virus-related multi-phenotypic sinonasal carcinoma (HMSC), discussing its histology, clinical presentation, and treatment outcomes. HMSC was found to have aggressive morphology but an indolent clinical course, with surgery being the main treatment modality and adjuvant radiotherapy potentially increasing disease-free interval for patients.

LARYNGOSCOPE (2021)

Article Medicine, Research & Experimental

Detection of HPV16/18 E6 Oncoproteins in Head and Neck Squamous Cell Carcinoma Using a Protein Immunochromatographic Assay

Anna Menegaldo et al.

Summary: By detecting HPV16/18 E6 oncoproteins in cytological specimens of OPSCC and CUP using a protein immunochromatographic assay, this study found it to be a feasible, highly reliable, and low-invasive method for assessing HPV-driven status in these cancers.

LARYNGOSCOPE (2021)

Review Obstetrics & Gynecology

Implementation of HPV Self-sampling in Cervical Screening Programs Increases Participation Rates: A Literature Review

C. E. Schmeink et al.

Summary: The literature shows that HPV vaginal self-sampling is feasible, highly acceptable and above all has a high diagnostic accuracy in detecting HPV and CIN2 +. Furthermore, HPV self-sampling followed by Pap smear triage in hr-HPV positive women is cost-effective. Additionally offering mailed self-sample kits, ideally in combination with education, has been proven to improve participation and subsequently CIN2+ detection.

INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY (2021)

Review Biotechnology & Applied Microbiology

The human papillomavirus oncoproteins: a review of the host pathways targeted on the road to transformation

James A. Scarth et al.

Summary: Persistent infection with high-risk human papillomaviruses (HR-HPVs) can lead to various cancers, with the oncoproteins E5, E6, and E7 playing key roles in tumorigenesis. These oncoproteins manipulate the host cellular environment, promoting viral replication, prolonged infection, and eventually malignant transformation.

JOURNAL OF GENERAL VIROLOGY (2021)

Article Genetics & Heredity

Human Papillomavirus DNA Detection by Droplet Digital PCR in Formalin-Fixed Paraffin-Embedded Tumor Tissue from Oropharyngeal Squamous Cell Carcinoma Patients

Camila Marques Schiavetto et al.

Summary: HPV DNA detection by ddPCR is highly specific but moderately sensitive for determining HPV status in OPSCC. Results show that combination of p16-IHC and ddPCR may improve clinical management in OPSCC patients.

MOLECULAR DIAGNOSIS & THERAPY (2021)

Review Obstetrics & Gynecology

2020 WHO Classification of Female Genital Tumors

Anne Kathrin Hoehn et al.

Summary: The 2020 WHO classification focuses on distinguishing between HPV-associated and HPV-independent squamous cell carcinoma of the lower female genital organs. Differentiation is also made between VIN and AC according to their association with HPV. Immunohistochemical p16 expression is considered a surrogate marker for HPV association in AC of the cervix uteri.

GEBURTSHILFE UND FRAUENHEILKUNDE (2021)

Review Oncology

Human Papillomavirus in Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Kim J. W. Chang Sing Pang et al.

Summary: This meta-analysis examines the prevalence of HPV in sinonasal squamous cell carcinoma (SNSCC) and found an overall prevalence of 26%. The study indicated that HPV prevalence was higher in subsites with high exposure to secretion flow and in geographic regions with high HPV+ oropharyngeal squamous cell carcinoma prevalence.

CANCERS (2021)

Review Public, Environmental & Occupational Health

Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation

Arnaud John Kombe Kombe et al.

Summary: HPV is the most common pathogen responsible for female cancers, with infections related to various diseases. The distribution of HPV infections and related diseases varies significantly depending on factors such as region and population.

FRONTIERS IN PUBLIC HEALTH (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Biology of HPV Mediated Carcinogenesis and Tumor Progression

Pippa F. Cosper et al.

Summary: The article provides an overview of HPV virus classification, genetic structure, life cycle, and its role in cancer. The virus promotes tumorigenesis through integration into host genome, regulating cell cycle and apoptosis, and suppressing immune response.

SEMINARS IN RADIATION ONCOLOGY (2021)

Article Biochemical Research Methods

Optimization of droplet digital PCR assays for the type-specific detection and quantification of five HPV genotypes, including additional data on viral loads of nine different HPV genotypes in cervical carcinomas

Kaliff Malin et al.

Summary: The study evaluated the use of the ddPCR system for HPV genotype VL analysis and found no difference in VL between tumors with multiple and single genotype infections. Tumors from women aged 60 years or older or containing certain HPV genotypes and genera were associated with a higher VL.

JOURNAL OF VIROLOGICAL METHODS (2021)

Review Oncology

Human papillomavirus as a driver of head and neck cancers

Maria Elisa Sabatini et al.

BRITISH JOURNAL OF CANCER (2020)

Review Obstetrics & Gynecology

Primary HPV screening for cervical cancer

Neerja Bhatla et al.

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY (2020)

Review Obstetrics & Gynecology

A systematic review of self-sampling for HPV testing in Africa

Zita Aleyo Nodjikouambaye et al.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2020)

Review Dentistry, Oral Surgery & Medicine

Global Burden of Head and Neck Cancer

Quazi Billur Rahman et al.

ORAL AND MAXILLOFACIAL SURGERY CLINICS OF NORTH AMERICA (2020)

Review Pathology

HPV-related squamous cell carcinoma of oropharynx: a review

Siavash Rahimi

JOURNAL OF CLINICAL PATHOLOGY (2020)

Review Oncology

HPV Detection in Head and Neck Squamous Cell Carcinomas: What Is the Issue?

Jeremy Gbenakpon Augustin et al.

FRONTIERS IN ONCOLOGY (2020)

Review Medicine, General & Internal

Human papillomavirus in 2019: An update on cervical cancer prevention and screening guidelines

Salina Zhang et al.

CLEVELAND CLINIC JOURNAL OF MEDICINE (2019)

Editorial Material Medicine, General & Internal

Cervical Cancer Screening More Choices in 2019

George F. Sawaya et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

Review Immunology

Association of human papillomavirus infection and inflammation in cervical cancer

Nima Hemmat et al.

PATHOGENS AND DISEASE (2019)

Article Pathology

The evolving landscape of HPV-related neoplasia in the head and neck

Kyle M. Devins et al.

HUMAN PATHOLOGY (2019)

Article Otorhinolaryngology

HPV-16 viral load in oropharyngeal squamous cell carcinoma using digital PCR

Annika Antonsson et al.

ACTA OTO-LARYNGOLOGICA (2018)

Article Obstetrics & Gynecology

Epidemiology and burden of HPV-related disease

Beatriz Serrano et al.

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY (2018)

Article Oncology

HPV: Molecular pathways and targets

Shilpi Gupta et al.

CURRENT PROBLEMS IN CANCER (2018)

Review Infectious Diseases

Understanding the HPV integration and its progression to cervical cancer

Mariel Araceli Oyervides-Munoz et al.

INFECTION GENETICS AND EVOLUTION (2018)

Article Health Care Sciences & Services

HPV Self-Sampling for Cervical Cancer Screening Among Ethnic Minority Women in South Florida: a Randomized Trial

Olveen Carrasquillo et al.

JOURNAL OF GENERAL INTERNAL MEDICINE (2018)

Article Public, Environmental & Occupational Health

Performance of OncoE6 cervical test with collection methods enabling self-sampling

Amrei Krings et al.

BMC WOMENS HEALTH (2018)

Review Medicine, Research & Experimental

The human papillomavirus (HPV)-related cancer biology: An overview

Rodrigo Pinheiro Araldi et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Multidisciplinary Sciences

Differences in the viral genome between HPV- positive cervical and oropharyngeal cancer

Bailey A. LeConte et al.

PLOS ONE (2018)

Review Microbiology

Involvement of Human Papillomaviruses in Cervical Cancer

Xuelian Wang et al.

FRONTIERS IN MICROBIOLOGY (2018)

Review Oncology

The molecular landscape of head and neck cancer

C. Rene Leemans et al.

NATURE REVIEWS CANCER (2018)

Review Otorhinolaryngology

Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review

M. Re et al.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2017)

Article Oncology

Worldwide burden of cancer attributable to HPV by site, country and HPV type

Catherine de Martel et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

Article Otorhinolaryngology

Ultrasensitive detection of oncogenic human papillomavirus in oropharyngeal tissue swabs

Andre Isaac et al.

JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY (2017)

Article Oncology

The molecular mechanism of human papillomavirus-induced carcinogenesis in head and neck squamous cell carcinoma

Daisuke Sano et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2016)

Letter Immunology

Who evaluates p16 immunohistochemistry?

Christian Gronhoj Larsen et al.

APMIS (2015)

Review Virology

Human papillomavirus molecular biology and disease association

John Doorbar et al.

REVIEWS IN MEDICAL VIROLOGY (2015)

Review Anatomy & Morphology

Technical Review: In Situ Hybridization

Ellen Jensen

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2014)

Article Oncology

Clinical and scientific impact of human papillomavirus on head and neck cancer

Jeffrey M. Friedman et al.

WORLD JOURNAL OF CLINICAL ONCOLOGY (2014)

Article Biochemical Research Methods

Absolute quantification by droplet digital PCR versus analog real-time PCR

Christopher M. Hindson et al.

NATURE METHODS (2013)

Article Otorhinolaryngology

High-Risk Human Papillomavirus Detection in Oropharyngeal, Nasopharyngeal, and Oral Cavity Cancers Comparison of Multiple Methods

Heather M. Walline et al.

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY (2013)

Article Otorhinolaryngology

Detection of Human Papillomavirus in Clinical Samples

William H. Westra

OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA (2012)

Review Pathology

HPV Detection Methods in Head and Neck Cancer

Aldo Venuti et al.

HEAD & NECK PATHOLOGY (2012)

Article Chemistry, Analytical

High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number

Benjamin J. Hindson et al.

ANALYTICAL CHEMISTRY (2011)

Article Biotechnology & Applied Microbiology

International standard reagents for HPV detection

Sonia R. Pagliusi et al.

DISEASE MARKERS (2007)

Article Obstetrics & Gynecology

Role of human papillomavirus in the carcinogenesis of squamous cell carcinoma and adenocarcinoma of the cervix

WAA Tjalma et al.

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY (2005)

Article Medicine, General & Internal

HPV DNA testing of self-collected vaginal samples compared with cytologic screening to detect cervical cancer

TC Wright et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2000)