Outcomes of Patients With Active Cancer and COVID-19 in the Intensive-Care Unit: A Multicenter Ambispective Study

Article Infectious Diseases

Decreased Case Fatality Rate of COVID-19 in the Second Wave: A study in 53 countries or regions

Guihong Fan et al.

Summary: A study found that in 53 countries or regions with the highest COVID-19 death tolls, 43 had lower CFR estimates in the ongoing second wave than in the first wave. This could be due to the effects of social distancing measures.

TRANSBOUNDARY AND EMERGING DISEASES (2021)

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Article Oncology

Acute Immune Signatures and Their Legacies in Severe Acute Respiratory Syndrome Coronavirus-2 Infected Cancer Patients

Sultan Abdul-Jawad et al.

Summary: The study found that solid cancer patients exposed to SARS-CoV-2 exhibit immune signatures similar to COVID-19 patients, while hematological cancer patients show more complex immune responses that may affect treatment and recovery. Recovery from SARS-CoV-2 infection leaves distinct immunological legacies in hematological cancer patients.

CANCER CELL (2021)

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Article Critical Care Medicine

Increased susceptibility to intensive care unit-acquired pneumonia in severe COVID-19 patients: a multicentre retrospective cohort study

Jean-Francois Llitjos et al.

Summary: The study showed that COVID-19 patients have a higher risk of developing ICU-acquired pneumonia compared to patients with bacterial or non-SARS-CoV-2 viral pneumonia. The risk of ICU-acquired pneumonia remained independently associated with COVID-19 in mechanically ventilated patients, suggesting a potential unique pathogenesis of pneumonia in COVID-19 patients. Additional research is needed to investigate the underlying mechanisms leading to this increased risk.

ANNALS OF INTENSIVE CARE (2021)

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Article Multidisciplinary Sciences

ICU outcomes and survival in patients with severe COVID-19 in the largest health care system in central Florida

Eduardo Oliveira et al.

Summary: Our study in the largest healthcare system in Florida described the clinical characteristics and outcomes of severe COVID-19 patients admitted to ICU. The study showed that survivors of severe COVID-19 had longer durations of mechanical ventilation, hospital stay, and ICU stay compared to non-survivors.

PLOS ONE (2021)

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Article Oncology

COVID-19 in Cancer Patients, Risk Factors for Disease and Adverse Outcome, a Population-Based Study From Norway

Tom Borge Johannesen et al.

Summary: In this study, researchers aimed to identify factors associated with higher risk of COVID-19 and adverse outcomes among cancer patients. The study found that cancer patients had similar age-adjusted rates of COVID-19 as the general population. Patients who had undergone major surgery within the past 3 months had an increased risk of COVID-19, but no increased risk was found for other oncological treatment modalities. Patients with distant metastases had a significantly increased risk of death due to COVID-19.

FRONTIERS IN ONCOLOGY (2021)

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Article Critical Care Medicine

Case fatality inequalities of critically ill COVID-19 patients according to patient-, hospital- and region-related factors: a French nationwide study

Antoine Guillon et al.

Summary: This study examines the association between ICU bed occupancy and case fatality rate of critically ill COVID-19 patients, revealing factors such as age, comorbid conditions, and ICU experience impacting mortality, with regions having high ICU occupancy rates showing increased death rates.

ANNALS OF INTENSIVE CARE (2021)

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Review Oncology

Mortality in Cancer Patients With COVID-19 Who Are Admitted to an ICU or Who Have Severe COVID-19: A Systematic Review and Meta-Analysis

Amogh Rajeev Nadkarni et al.

Summary: This systematic review and meta-analysis found that critically ill cancer patients with COVID-19 admitted to the ICU had a mortality rate of 60.2%, with cancer patients having higher odds of death compared to noncancer patients. This study highlights the importance of considering admission to the ICU for selected cancer patients with severe COVID-19.

JCO GLOBAL ONCOLOGY (2021)

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Letter Oncology