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Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer

FRONTIERS IN ONCOLOGY (2022)

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Circular RNA CUL2 regulates the development of colorectal cancer by modulating apoptosis and autophagy via miR-208a-3p/PPP6C

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CRAFT: a bioinformatics software for custom prediction of circular RNA functions

Anna Dal Molin et al.

Summary: Circular RNAs are stable and pleiotropic molecules that modulate gene expression and signaling pathways, and thus play a role in human diseases and cancer. We developed a computational pipeline called CRAFT to predict the sequence and molecular interactions of circRNAs with miRNAs and RBP, providing a valuable tool for functional investigation.

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Sensitive, reliable and robust circRNA detection from RNA-seq with CirComPara2

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Summary: Circular RNAs (circRNAs) are important functional RNAs involved in biological processes and disease mechanisms. Current computational methods for circRNA identification have limitations, and we developed CirComPara2, which combines multiple detection methods to improve the accuracy and recall rates. Our method outperformed state-of-the-art tools and is a reliable approach for comprehensive transcriptome characterization.

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Oncogenic circRNA C190 Promotes Non-Small Cell Lung Cancer via Modulation of the EGFR/ERK Pathway

Afeez Adekunle Ishola et al.

Summary: Lung cancers, particularly non-small cell lung cancers, have a poor prognosis. A circular noncoding RNA called C190 has been identified as a negative prognostic biomarker for lung cancer, and this study explores its mechanistic function and potential as a therapeutic target for NSCLC.

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hsa_circ_0003410 promotes hepatocellular carcinoma progression by increasing the ratio of M2/M1 macrophages through the miR-139-3p/CCL5 axis

Pei Cao et al.

Summary: The study found that hsa_circ_0003410 in HCC can promote the proliferation and migration of tumor cells, regulate the target gene CCL5, activate and recruit M2 macrophages, and promote the progression of HCC.

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Circular RNA Sequencing Reveals Serum Exosome Circular RNA Panel for High-Grade Astrocytoma Diagnosis

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Summary: This study revealed a comprehensive landscape of circRNAs in exosomes and cells of high-grade astrocytoma (HGA). The serum exosome circRNA panel and tissue circRNAs have potential for liquid biopsy and prognosis monitoring in HGA. Exosome circRNAs as novel targets should facilitate further biomarker discovery and aid in HGA diagnosis and therapy monitoring.

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Circ_0000658 knockdown inhibits epithelial-mesenchymal transition in bladder cancer via miR-498-induced HMGA2 downregulation

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Summary: This study reveals the tumor-promoting role of circ_0000658 in bladder cancer and its regulation through the miR-498/HMGA2 axis.

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Circular RNA circGLIS3 promotes bladder cancer proliferation via the miR-1273f/SKP1/Cyclin D1 axis

Shuilian Wu et al.

Summary: Extensive research has confirmed that circRNA circGLIS3 plays an oncogene role in bladder cancer by affecting the proliferation, migration, and invasion of bladder cancer cells, as well as regulating cell cycle progression through the upregulation of cyclin D1 expression.

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Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1

Jin Wang et al.

Summary: The study found that circCSPP1 is upregulated in colon cancer and its overexpression promotes proliferation, migration, and invasion of colon cancer cells. Mechanistically, circCSPP1 binds with miR-431 and regulates the expression of its target genes ROCK1 and ZEB1.

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Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p

Yu-Zhong Yu et al.

Summary: Hsa_circ_0003258 is upregulated in prostate cancer and associated with tumor progression. It promotes cell migration and tumor metastasis, while knockdown of hsa_circ_0003258 has the opposite effect. Mechanistically, hsa_circ_0003258 functions by sponging miR-653-5p and increasing the expression of ARHGAP5. Additionally, hsa_circ_0003258 physically binds to IGF2BP3 and enhances HDAC4 mRNA stability, activating the ERK signaling pathway and triggering EMT programming.

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CircMET promotes tumor proliferation by enhancing CDKN2A mRNA decay and upregulating SMAD3

Lei Yang et al.

Summary: This study reveals the role of circular RNA CircMET in promoting the development of Xp11.2 translocation/NONO-TFE3 fusion renal cell carcinoma (NONO-TFE3 tRCC). CircMET interacts with specific proteins to regulate mRNA decay of key genes and absorb miRNA, thereby influencing tumor cell proliferation and post-transcriptional regulation.

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Article Biochemistry & Molecular Biology

circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad signaling

Lin Zheng et al.

Summary: This study revealed a novel circular RNA (circPTEN1) generated from the PTEN gene, which is downregulated in colorectal cancer and associated with poor survival. Low expression of circPTEN1 promotes metastasis and invasion, while overexpression shows opposite effects. Mechanistically, circPTEN1 binds to Smad4 and disrupts its interaction with Smad2/3, inhibiting the formation and translocation of Smad complexes. Additionally, eIF4A3 suppresses the cyclization of circPTEN1.

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The circROBO1/KLF5/FUS feedback loop regulates the liver metastasis of breast cancer by inhibiting the selective autophagy of afadin

Zehao Wang et al.

Summary: This study revealed that circROBO1 is upregulated in breast cancer liver metastasis and is associated with poor prognosis. CircROBO1 facilitates the carcinogenesis and liver metastasis of breast cancer through the circROBO1/KLF5/FUS feedback loop, which inhibits the selective autophagy of afadin by suppressing the transcription of BECN1.

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Article Biotechnology & Applied Microbiology

Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo

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Summary: LEAPER 2.0 utilizes circ-arRNA to achieve higher editing efficiency and reduce off-target editing, showing successful editing effects in cell culture and a mouse model.

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Article Biotechnology & Applied Microbiology

Efficient in vitro and in vivo RNA editing via recruitment of endogenous ADARs using circular guide RNAs

Dhruva Katrekar et al.

Summary: In this study, circular ADAR-recruiting guide RNAs (cadRNAs) were engineered to achieve more efficient and durable RNA editing without the need for exogenous proteins. The cadRNAs demonstrated robust and long-lasting RNA editing across multiple sites and cell lines, with high specificity. In vivo delivery of cadRNAs via adeno-associated viruses showed significant RNA editing in mouse livers and correction of a genetic mutation. cadRNAs enable programmable RNA editing with potential gene therapeutic applications.

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CircNet 2.0: an updated database for exploring circular RNA regulatory networks in cancers

Yigang Chen et al.

Summary: circRNAs, important molecules in cancer diagnosis, act as sponges of microRNAs to regulate transcription and translation. The updated CircNet database integrates circRNAs from various sources and predicts target miRNAs to construct high-quality circRNA-miRNA-gene regulatory networks, providing strong data support in the biomedical fields.

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ViroidDB: a database of viroids and viroid-like circular RNAs

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Summary: ViroidDB is a value-added database that collects known viroid and viroid-like circular RNA sequences, with about 10,000 unique sequences included. Each sequence's secondary structure, ribozyme content, and cluster membership are predicted through a custom pipeline optimized for circular RNAs. Users can explore the data through a purpose-built user interface, featuring visualizations, multiple sequence alignments, and bulk data download capabilities.

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CircKDM4B suppresses breast cancer progression via the miR-675/NEDD4L axis

Xiang-Yu Guo et al.

Summary: This study reveals the tumor-suppressor role of circKDM4B in breast cancer, especially in inhibiting tumor growth, metastasis, and angiogenesis, making it a potential therapeutic target for breast cancer progression.

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Circular RNA detection methods: A minireview

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Summary: Circular RNA (circRNA), a novel type of RNA, is implicated in developmental and metabolic diseases. CircRNAs show tissue-specific expression and are stable, abundant, and highly conserved. Accurate profiling of circRNA is essential for their clinical application, and new methods such as ddPCR and isothermal exponential amplification have been developed to enhance sensitivity and specificity in circRNA detection.

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CircMTO1 suppresses hepatocellular carcinoma progression via the miR-541-5p/ZIC1 axis by regulating Wnt/β-catenin signaling pathway and epithelial-to-mesenchymal transition

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Summary: circMTO1 acts as a tumor suppressor in HCC by regulating the Wnt/beta-catenin signaling pathway and epithelial-to-mesenchymal transition through the circMTO1/miR-541-5p/ZIC1 axis. It inhibits HCC cell proliferation, migration, invasion, and promotes apoptosis.

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Article Cell Biology

Exosomal circRELL1 serves as a miR-637 sponge to modulate gastric cancer progression via regulating autophagy activation

Huaiming Sang et al.

Summary: This study identifies the suppressive roles of circRELL1/miR-637/EPHB3 axis through autophagy activation in gastric cancer, providing a promising novel diagnostic circulating biomarker and therapeutic target in gastric cancer.

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Comprehensive Assessment of Serum hsa_circ_0070354 as a Novel Diagnostic and Predictive Biomarker in Non-small Cell Lung Cancer

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Summary: This study explores the role of circular RNA (hsa_circ_0070354) in the diagnosis and prognosis of non-small cell lung cancer (NSCLC). Hsa_circ_0070354 is highly expressed in NSCLC tissues, cells, and serum, and it shows sensitivity, stability, and repeatability. It is a novel sensitive index for diagnosing NSCLC and a crucial marker for poor prognosis.

FRONTIERS IN GENETICS (2022)

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Article Biotechnology & Applied Microbiology

circ-EIF6 encodes EIF6-224aa to promote TNBC progression via stabilizing MYH9 and activating the Wnt/beta-catenin pathway

Yaming Li et al.

Summary: The protein-coding ability of circRNAs in TNBC has not been well understood. This study identified a circRNA called circ-EIF6, which was associated with poorer prognosis and clinicopathological characteristics in TNBC patients. Functional experiments showed that circ-EIF6 promoted proliferation and metastasis of TNBC cells, mediated by encoding a novel peptide called EIF6-224aa that interacted with MYH9, leading to activation of the Wnt/β-catenin pathway.

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Article Biotechnology & Applied Microbiology

circMRPS35 promotes malignant progression and cisplatin resistance in carcinoma

Peng Li et al.

Summary: This study identifies circMRPS35 as a highly expressed circRNA in HCC and shows that its knockdown inhibits cell proliferation, migration, invasion, and colony formation, as well as tumor growth. circMRPS35 regulates PTEN expression and degradation through miR-148a and STX3. Additionally, the circMRPS35-encoded peptide circMRPS35-168aa promotes cisplatin resistance in HCC.

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Article Biochemistry & Molecular Biology

CSCD2: an integrated interactional database of cancer-specific circular RNAs

Jing Feng et al.

Summary: The significant role of circRNAs in cancer has been acknowledged, emphasizing the importance of characterizing circRNAs interactions with other functional molecules; CSCD2, an updated version of cancer-specific circRNA database, offers a comprehensive resource including a large number of circRNAs from human cancer and normal tissues/cell lines; CSCD2 not only identifies a vast number of cancer-specific circRNAs but also predicts potential miRNA-circRNA and RBP-circRNA interactions, providing enhanced tools for exploring circRNAs function and regulation in cancer.

NUCLEIC ACIDS RESEARCH (2022)

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circMine: a comprehensive database to integrate, analyze and visualize human disease-related circRNA transcriptome

Wenliang Zhang et al.

Summary: The study introduces circMine as a tool to assist researchers in investigating circRNA transcriptome data. CircMine provides a large amount of data and online analytical functions to assess the clinical and biological significance of circRNA, and additional tools to systematically discover circRNA-miRNA interactions and circRNA translatability.

NUCLEIC ACIDS RESEARCH (2022)

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Drugging the undruggable microRNAs

Dejun Liu et al.

Summary: miRNAs, previously considered undruggable, have recently been shown to be targetable with small molecules such as SMIs and SMDs, which inhibit their biogenesis or induce degradation. These small molecules demonstrate high potency and specificity in miRNA inhibition, providing new opportunities for therapeutic development towards previously considered undruggable targets.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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circRASGRF2 functions as an oncogenic gene in hepatocellular carcinoma by acting as a miR-1224 sponge

Di Wu et al.

Summary: This study identified circRASGRF2 as significantly upregulated in HCC tissues and cell lines, promoting proliferation and migration of liver cancer cells by sponging miR-1224. Mechanistically, circRASGRF2 was found to enhance the expression of focal adhesion kinase (FAK) in HCC. These findings suggest circRASGRF2 as a central component linking circRNAs to HCC progression, making it a potential therapeutic target.

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Circular RNA Sequencing of Maternal Platelets: A Novel Tool for the Identification of Pregnancy-Specific Biomarkers

Cees Oudejans et al.

Summary: In this study, transcriptome analysis of circular RNA (circRNA) from maternal platelets in the first trimester allowed for the identification of novel pregnancy-specific RNA biomarkers. The upregulation of specific circRNAs in first-trimester platelet RNA may have implications for assessing maternal and fetal well-being in the future.

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The circular RNA hsa_circ_000780 as a potential molecular diagnostic target for gastric cancer

Jian Song et al.

Summary: This study identified a novel circRNA expression profile in human gastric cancer, with hsa_circ_000780 significantly downregulated in both GC tissue and gastric fluid specimens, thus indicating its potential as a new biomarker for early gastric cancer screening.

BMC MEDICAL GENOMICS (2021)

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Article Oncology

CircADARB1 serves as a new biomarker in natural killer T-cell lymphoma and a potential regulator of p-Stat3

Mei Mei et al.

Summary: The study found that circADARB1 was highly expressed in the plasma of NKTCL patients. Knockdown of circADARB1 inhibited proliferation of NKTCL cells and it bound to miR-214-3p to regulate the expression of p-Stat3.

CANCER CELL INTERNATIONAL (2021)

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Article Oncology

Circular RNA circLMO7 acts as a microRNA-30a-3p sponge to promote gastric cancer progression via the WNT2/β-catenin pathway

Jiacheng Cao et al.

Summary: The study found that circLMO7 can promote the proliferation, migration, and invasion of gastric cancer cells by acting as a sponge for miR-30a-3p to affect the WNT2/beta-Catenin pathway. Animal experiments also showed that circLMO7 could promote gastric cancer growth and metastasis in vivo. Furthermore, circLMO7 can also impact the glutamine metabolism of gastric cancer cells through the WNT2/beta-Catenin pathway to enhance its malignant biological function.

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Article Oncology

Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway

Xuehui Wang et al.

Summary: Hsa_circ_0005273 is overexpressed in breast cancer tissues and cell lines, promoting BC progression by regulating the miR-200a-3p/YAP1 axis and inactivating the Hippo signaling pathway. Depletion of hsa_circ_0005273 inhibits tumor cell proliferation, migration, and cell cycle progression, suggesting it as a potential therapeutic target for breast cancer.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Circular RNA circSDHC serves as a sponge for miR-127-3p to promote the proliferation and metastasis of renal cell carcinoma via the CDKN3/E2F1 axis

Junjie Cen et al.

Summary: CircSDHC expression is correlated with advanced TNM stage and poor survival in RCC patients, and it promotes RCC progression by competitively binding to miR-127-3p, thereby preventing its suppression of CDKN3 and the E2F1 pathway. This suggests that circSDHC could be a potential therapeutic target in RCC treatment.

MOLECULAR CANCER (2021)

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Review Biotechnology & Applied Microbiology

Next-Generation CRISPR Technologies and Their Applications in Gene and Cell Therapy

C. M. Alejandra Zeballos et al.

Summary: The emergence of CRISPR nucleases has revolutionized biotechnology by providing an easy, efficient, and versatile platform for editing DNA. New CRISPR-based modalities have been developed to catalyze editing without the requirement for DNA double-strand break repair, offering promising therapeutic applications and facing challenges for clinical implementation.

TRENDS IN BIOTECHNOLOGY (2021)

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Article Multidisciplinary Sciences

circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity

Botai Li et al.

Summary: It was found that circNDUFB2 is downregulated in NSCLC tissues and inhibits the growth and metastasis of NSCLC cells by enhancing the interaction between TRIM25 and IGF2BPs. circNDUFB2 also activates anti-tumor immune responses by binding to RIG-I.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

isoCirc catalogs full-length circular RNA isoforms in human transcriptomes

Ruijiao Xin et al.

Summary: isoCirc is a strategy for sequencing full-length circRNA isoforms, providing a comprehensive catalog of circRNA isoforms and identifying widespread alternative splicing events within circRNAs. This strategy and resource offer valuable insights for studying circRNAs in human transcriptomes.

NATURE COMMUNICATIONS (2021)

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Article Medicine, Research & Experimental

circRNA hsa_circ_0018414 inhibits the progression of LUAD by sponging miR-6807-3p and upregulating DKK1

Yuanshan Yao et al.

Summary: Our research revealed that circ_0018414 functions as a tumor inhibitor in LUAD by inhibiting cell proliferation and stemness while promoting apoptosis. Furthermore, circ_0018414 upregulation led to inactivation of the Wnt/beta-catenin pathway by enhancing the expression of DKK1 through sponging miR-6807-3p. This study suggests a potential therapeutic target for LUAD treatment.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Cell Biology

Circular RNA CircNOLC1, Upregulated by NF-KappaB, Promotes the Progression of Prostate Cancer via miR-647/PAQR4 Axis

Wenbin Chen et al.

Summary: Our study identified that circNOLC1 is overexpressed in prostate cancer cells and tissues, promoting proliferation and migration of tumor cells while activating the PI3K/Akt pathway through the miR-647/PAQR4 axis. We also showed that NF-kappaB upregulates circNOLC1, leading to the progression of prostate cancer.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Biochemistry & Molecular Biology

CircRNF220, not its linear cognate gene RNF220, regulates cell growth and is associated with relapse in pediatric acute myeloid leukemia

Xiaodan Liu et al.

Summary: The circRNA circRNF220 showed high sensitivity and specificity in distinguishing pediatric AML, serving as a potential biomarker for accurate diagnosis and relapse prediction. Its function in inhibiting proliferation and promoting apoptosis in AML cells highlights its therapeutic potential. The mechanistic role of circRNF220 as a miR-30a sponge to regulate target genes MYSM1 and IER2 provides insights into AML pathogenesis and relapse mechanisms.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

CircEAF2 counteracts Epstein-Barr virus-positive diffuse large B-cell lymphoma progression via miR-BART19-3p/APC/β-catenin axis

Chen-xing Zhao et al.

Summary: In this study, a novel circRNA circEAF2 was identified, which was found to be downregulated in EBV + DLBCL and negatively correlated with EBV infection and DLBCL progression. CircEAF2 counteracted EBV + DLBCL progression via the miR-BART19-3p/APC/beta-catenin axis, suggesting circEAF2 as a potential prognostic biomarker. Therapeutic targeting of EBV-encoded miRNA may prove to be a promising strategy in treating EBV-associated lymphoid malignancies.

MOLECULAR CANCER (2021)

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Article Oncology

The circular RNA circZFR phosphorylates Rb promoting cervical cancer progression by regulating the SSBP1/CDK2/cyclin E1 complex

Mingyi Zhou et al.

Summary: This study identified an upregulated circRNA signature in cervical cancer tissues, with circZFR being significantly overexpressed and promoting cell proliferation, invasion, and tumor growth. Functional experiments revealed circZFR's interaction with SSBP1, leading to the assembly of CDK2/cyclin E1 complexes and activation of cell cycle progression and proliferation. These findings suggest circZFR as a potential biomarker and therapeutic target for cervical cancer patients.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Oncology

CircAGAP1 promotes tumor progression by sponging miR-15-5p in clear cell renal cell carcinoma

Qi Lv et al.

Summary: This study reveals that circAGAP1 is significantly upregulated in ccRCC tissues and is closely associated with tumor size, nuclear grade, and clinical stage. Mechanistic studies demonstrate that cytoplasmic circAGAP1 functions as a ceRNA by sponging miR-15-5p, thereby promoting E2F3 expression. Targeting circAGAP1 may offer a new therapeutic strategy for ccRCC.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Biochemistry & Molecular Biology

CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer

Ya Fan et al.

Summary: The study revealed that HRD1 is significantly underexpressed in triple-negative breast cancer (TNBC) and inhibits cancer progression by inducing proteasomal degradation of Vimentin. CircNR3C2 is also downregulated in TNBC and enhances the tumor-suppressive effects of HRD1 through sponging miR-513a-3p. This circNR3C2/miR-513a-3p/HRD1/Vimentin axis negatively regulates TNBC metastasis and may serve as potential prognostic biomarkers for aggressive breast cancer.

MOLECULAR CANCER (2021)

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Article Biotechnology & Applied Microbiology

Comprehensive profiling of circular RNAs with nanopore sequencing and CIRI-long

Jinyang Zhang et al.

Summary: This study presents a method for enrichment and full-length sequencing of circRNA isoforms using nanopore technology, allowing high-throughput detection and reconstruction of circRNAs. The developed algorithm, CIRI-long, accurately reconstructs the sequence of circRNAs from long-read sequencing data. Analysis of adult mouse brain samples identified diverse circRNA types, including a novel intronic self-ligated circRNA with special splicing and expression patterns.

NATURE BIOTECHNOLOGY (2021)

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Article Cell Biology

Circular RNA circ_103820 suppresses lung cancer tumorigenesis by sponging miR-200b-3p to release LATS2 and SOCS6

Yongbin Chi et al.

Summary: A novel circular RNA, hsa_circ_103820, was identified in lung cancer, showing potential tumor suppressive function by inhibiting proliferation, migration, and invasion of cancer cells. The mechanism involves the direct targeting of miR-200b-3p by hsa_circ_103820 and the regulation of downstream target genes LATS2 and SOCS6.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

circST6GALNAC6 suppresses bladder cancer metastasis by sponging miR-200a-3p to modulate the STMN1/EMT axis

Shuo Tan et al.

Summary: Bladder cancer is an aggressive malignancy with high recurrence rates and distant metastasis, and circular RNAs (circRNAs) play important regulatory roles in cancer progression. In this study, circST6GALNAC6 was identified as downregulated in bladder cancer tissues and cells, inhibiting cell proliferation, migration, invasion, and epithelial-mesenchymal transition both in vitro and in vivo by sponging miR-200a-3p to regulate STMN1 expression. This SP1-induced circST6GALNAC6/miR-200a-3p/STMN1 axis provides potential prognostic biomarkers and therapeutic targets for bladder cancer metastasis.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

Circular RNA circRNA_0000094 sponges microRNA-223-3p and up-regulate F-box and WD repeat domain containing 7 to restrain T cell acute lymphoblastic leukemia progression

Yan Hou et al.

Summary: This study showed that circ_0000094 inhibits the progression of T cell acute lymphoblastic leukemia (T-ALL) by modulating the miR-223-3p/FBW7 axis.

HUMAN CELL (2021)

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Article Medicine, Research & Experimental

circDCUN1D4 suppresses tumor metastasis and glycolysis in lung adenocarcinoma by stabilizing TXNIP expression

Yingkuan Liang et al.

Summary: The aberrant expression of circRNAs plays a role in cancer progression through interactions with RNA-binding proteins (RBPs). A novel circRNA, circDCUN1D4, has been identified to be involved in the metastasis and glycolysis of lung adenocarcinoma (LUAD) by facilitating interactions between HuR and TXNIP proteins. It acts as a scaffold to enhance stability and transportation of TXNIP mRNA, ultimately suppressing metastasis and glycolysis of lung cancer cells in a TXNIP-dependent manner. The downregulated expression of circDCUN1D4 in lymph node metastatic tissues serves as an independent risk factor for the overall survival of LUAD patients.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Oncology

CircHIPK3 Promotes the Tumorigenesis and Development of Gastric Cancer Through miR-637/AKT1 Pathway

Dejun Yang et al.

Summary: A new circular RNA, circHIPK3, was identified in gastric cancer, where its upregulation was found to promote cell growth and metabolism while its downregulation had inhibitory effects. The regulatory pathway of circHIPK3/miR-637/AKT1 was discovered to be associated with oncogene activity and growth in gastric cancer.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

Circular RNA_PDHX Promotes the Proliferation and Invasion of Prostate Cancer by Sponging MiR-378a-3p

Yuanshen Mao et al.

Summary: In this study, it was found that circPDHX facilitated proliferation and invasion of PCa cells by sponging miR-378a-3p, while miR-378a-3p counteracted circPDHX-induced cell proliferation and expression of insulin-like growth factor 1 receptor (IGF1R) in PCa cells.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Hsa_circ_001659 serves as a novel diagnostic and prognostic biomarker for colorectal cancer

Baoyu He et al.

Summary: CRC is a prevalent global disease, requiring novel biomarkers for improved precision medicine. CircRNAs, particularly circ_001659, show promise as potential biomarkers for early diagnosis and prognosis of CRC. Mechanistic studies reveal the oncogenic role of circ_001659 and suggest potential therapeutic targets for CRC treatment.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Oncology

CircFAM73A promotes the cancer stem cell-like properties of gastric cancer through the miR-490-3p/HMGA2 positive feedback loop and HNRNPK-mediated β-catenin stabilization

Yiwen Xia et al.

Summary: The study revealed that circFAM73A is upregulated in gastric cancer tissues and is associated with poor prognosis in patients. Upregulation of circFAM73A enhances cell proliferation, migration, cisplatin resistance, and CSC-like properties in gastric cancer. Mechanistically, circFAM73A promotes gastric cancer malignancy through the miR-490-3p/HMGA2 positive feedback loop and recruitment of HNRNPK.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Biochemistry & Molecular Biology

A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling

Tianlu Jiang et al.

Summary: The study identified that circMAPK1 is downregulated in gastric cancer tissues, and its lower expression predicts poor survival. CircMAPK1 exerts a tumor suppressive effect through the encoded protein MAPK1-109aa, inhibiting the proliferation and invasion of gastric cancer cells.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

CircMEMO1 modulates the promoter methylation and expression of TCF21 to regulate hepatocellular carcinoma progression and sorafenib treatment sensitivity

Zhao-Ru Dong et al.

Summary: This study revealed that circMEMO1 is significantly downregulated in HCC samples and is closely related to the survival of HCC patients. Mechanistic analysis showed that circMEMO1 can modulate TCF21 gene expression and increase HCC cell sensitivity to sorafenib treatment, indicating its role as an important epigenetic modifier in HCC progression.

MOLECULAR CANCER (2021)

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Article Parasitology

Circular RNA ciRS-7 affects the propagation of Cryptosporidium parvum in HCT-8 cells by sponging miR-1270 to activate the NF-κB signaling pathway

Yan-Ling Yin et al.

Summary: The study revealed that Cryptosporidium infection caused significant alterations in circRNA expression profiles in host cells, with the upregulated circRNA ciRS-7 promoting C. parvum propagation by regulating the miR-1270/relA axis and affecting the NF-κB pathway. This study provides a novel perspective on the role of circRNA in Cryptosporidium infection and offers insights for implementing control strategies.

PARASITES & VECTORS (2021)

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Article Cell Biology

Up-regulated circBACH2 contributes to cell proliferation, invasion, and migration of triple-negative breast cancer

Xinxing Wang et al.

Summary: Research has shown that circBACH2 functions as an oncogenic circRNA in TNBC, promoting malignant progression through a novel miR-186-5p/miR-548c-3p/CXCR4 axis.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

Circ-HMGA2 (hsa_circ_0027446) promotes the metastasis and epithelial-mesenchymal transition of lung adenocarcinoma cells through the miR-1236-3p/ZEB1 axis

Zhongjian Yu et al.

Summary: The study shows that in lung adenocarcinoma, circ-HMGA2 promotes cell metastasis through the miR-1236-3p/EMT axis, indicating that it could be a therapeutic target in LUAD.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

CircSPI1 acts as an oncogene in acute myeloid leukemia through antagonizing SPI1 and interacting with microRNAs

Xiaoling Wang et al.

Summary: This study reveals that circSPI1, a circular RNA derived from the SPI1 gene, is highly expressed in AML and acts as an oncogene, promoting AML development through multiple interactions. CircSPI1 contributes to myeloid differentiation, proliferation, and apoptosis in AML cells by interacting with various factors, showcasing the complexity of SPI1 gene regulation involving circSPI1.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

Circular RNA hsa_circ_0006401 promotes proliferation and metastasis in colorectal carcinoma

Chenjing Zhang et al.

Summary: The study revealed that hsa_circ_0006401 is closely related to CRC metastasis and showed increased expression in metastatic CRC tissue samples. Silencing hsa_circ_0006401 expression inhibited proliferation and migration in vitro, while downregulation of hsa_circ_0006401 expression reduced CRC proliferation and liver metastasis in vivo. Hsa_circ_0006401 promotes CRC proliferation and migration by encoding peptides.

CELL DEATH & DISEASE (2021)

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Article Oncology

Clinical Assay for the Early Detection of Colorectal Cancer Using Mass Spectrometric Wheat Germ Agglutinin Multiple Reaction Monitoring

I-Jung Tsai et al.

Summary: Colorectal cancer is the third leading cause of cancer-related mortality globally. The study developed a detection method combining WGA chromatography with mass spectrometry to identify potential biomarkers for early diagnosis of CRC with high sensitivity and specificity. The research demonstrated the effectiveness of combining WGA-captured plasma PF4, ITIH4, and APOE levels as highly effective early diagnostic biomarkers for CRC patients.

CANCERS (2021)

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Article Cell Biology

Mechanism of circADD2 as ceRNA in Childhood Acute Lymphoblastic Leukemia

Yuting Zhu et al.

Summary: The study revealed that circADD2 is down-regulated in ALL, and its overexpression inhibits cell proliferation while promoting apoptosis. circADD2 functions by directly sponging miR-149-5p.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Oncology

Novel circular RNA circSOBP governs amoeboid migration through the regulation of the miR-141-3p/MYPT1/p-MLC2 axis in prostate cancer

Fan Chao et al.

Summary: This study investigates the role of circSOBP in prostate cancer metastasis and finds that circSOBP suppresses PCa cell migration and invasion by sponging miR-141-3p and regulating the MYPT1/p-MLC2 axis. Overexpression of circSOBP inhibits metastasis, while depletion increases migration and induces amoeboid migration. The results suggest that circSOBP could be a potential therapeutic target for preventing prostate cancer metastasis.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Environmental Sciences

Circ-SHPRH suppresses cadmium-induced transformation of human bronchial epithelial cells by regulating QKI expression via miR-224-5p

Mei Zhou et al.

Summary: In this study, we found that circ-SHPRH plays a crucial role in cadmium-induced carcinogenesis by regulating miR-224-5p to impact QKI expression, thereby inhibiting the transformation of BEAS-2B cells.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Article Oncology

CircPVT1 promotes proliferation of lung squamous cell carcinoma by binding to miR-30d/e

Jie Shi et al.

Summary: This study found that circPVT1 is upregulated in LUSC tissues, serum, and cell lines, with higher expression associated with shorter survival rates. In vitro and in vivo data demonstrated that circPVT1 promotes LUSC cell proliferation. Mechanistic analysis revealed that HuR regulates circPVT1, while circPVT1 acts as a competing endogenous RNA of miR-30d and miR-30e in alleviating their suppressive effects on the target gene CCNF.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Biochemistry & Molecular Biology

The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC

Xiaosong Wang et al.

Summary: The study revealed that circACTN4 is upregulated in breast cancer tissues and cells, promoting tumor growth, invasion, and metastasis, and correlating with clinical stage and prognosis. circACTN4 interacts with FUBP1 to activate MYC transcription, facilitating breast cancer progression.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

A novel NF-κB regulator encoded by circPLCE1 inhibits colorectal carcinoma progression by promoting RPS3 ubiquitin-dependent degradation

Zhen-xing Liang et al.

Summary: In this study, a novel protein circPLCE1-411 was identified as a key player in NF-kappa B activation in CRC. It inhibits NF-kappa B nuclear translocation by promoting the degradation of RPS3, leading to suppression of tumor proliferation and metastasis in CRC. Additionally, downregulation of circPLCE1 in CRC tissues is associated with poor patient survival.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner

Xin Liu et al.

Summary: The study identified an intron-derived circRNA, circMYH9, significantly upregulated in colorectal cancer tissues. CircMYH9 promotes colorectal cancer proliferation through modulating serine/glycine metabolism and redox homeostasis in a p53-dependent manner.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis

Yaxin Guo et al.

Summary: The study shows that circ3823 promotes CRC growth, metastasis, and angiogenesis through the circ3823/miR-30c-5p/TCF7 axis, suggesting its potential as a new diagnostic marker or treatment target for CRC patients. Additionally, the study also reveals the involvement of m6A modification in regulating the degradation of circ3823.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway

Jiaqi Wang et al.

Summary: The study revealed that circSPARC is upregulated in CRC patients and is associated with tumor progression and survival rates. Silencing circSPARC can inhibit CRC cell migration and proliferation. CircSPARC interacts with miR-485-3p to upregulate JAK2 expression, leading to the accumulation of p-STAT3.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability

Yu Zhang et al.

Summary: This study identified a new circRNA, circDIDO1, transcribed from the human DIDO1 gene, which functions as a tumor suppressor in gastric cancer by inhibiting cell proliferation, migration, and invasion. CircDIDO1 directly interacts with PARP1 and inhibits its activity, and promotes the degradation of PRDX2, leading to inactivation of downstream signaling pathways. CircDIDO1 may serve as a potential prognostic biomarker and therapeutic target for gastric cancer.

MOLECULAR CANCER (2021)

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Article Multidisciplinary Sciences

CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer

Xiaolin Wang et al.

Summary: The study identified circURI7 as a circRNA with significantly higher expression in gastric cancer, which inhibits cell migration and invasion by modulating alternative splicing of genes involved in the process of cell migration, thus suppressing GC metastasis.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Biology

Linking circular intronic RNA degradation and function in transcription by RNase H1

Xiang Li et al.

Summary: RNase H1 degrades a subgroup of ciRNAs in human cells, many of which contain high GC% and tend to form DNA:RNA hybrids (R-loops) for cleavage. One ciRNA, ciankrd52, shows a stronger ability of R-loop formation than its pre-mRNA, allowing for efficient transcriptional elongation via RNase H1 degradation. This mechanism likely limits ciRNA accumulation and resolves R-loops for transcriptional elongation at GC-rich ciRNA-producing loci.

SCIENCE CHINA-LIFE SCIENCES (2021)

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Article Cell Biology

Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p

Min Liang et al.

Summary: The study identified hsa_circ_0110389 as a novel upregulated circRNA in malignant-transformed gastric cancer cells, and found that it promotes gastric cancer progression via the miR-127-5p/miR-136-5p-SORT1 pathway. This circRNA may serve as a diagnostic/prognostic biomarker and therapeutic target for gastric cancer.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

High-throughput sequencing identified circular RNA circUBE2K mediating RhoA associated bladder cancer phenotype via regulation of miR-516b-5p/ARHGAP5 axis

Chen Yang et al.

Summary: This study identified circUBE2K as a tumor-promoting circRNA in bladder cancer, which functions as a ceRNA to regulate ARHGAP5 expression via sponging miR-516b-5p.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

circEVI5 acts as a miR-4793-3p sponge to suppress the proliferation of gastric cancer

Meinan Yan et al.

Summary: Our study demonstrated that circEVI5 can bind miR-4793-3p as a ceRNA to eliminate the negative regulation of FOXO1, therefore suppressing GC proliferation.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

hsa_circ_0003222 accelerates stemness and progression of non-small cell lung cancer by sponging miR-527

Changhui Li et al.

Summary: The study has demonstrated the significant role of hsa_circ_0003222 in NSCLC progression and resistance, with its high expression associated with disease stage, metastasis, and patient survival rate. Silencing hsa_circ_0003222 led to reduced stemness-like properties and chemoresistance in tumor cells.

CELL DEATH & DISEASE (2021)

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Article Genetics & Heredity

An autoregulation loop in fust-1 for circular RNA regulation in Caenorhabditis elegans

Dong Cao

Summary: This study identified FUST-1 as a regulator of circRNA formation in Caenorhabditis elegans, impacting the expression of multiple circRNAs. It was found that FUST-1 has little effect on the cognate linear mRNAs while regulating circRNA formation. An autoregulation loop was also discovered within fust-1, emphasizing the importance of FUST-1a isoform in circRNA regulation.

GENETICS (2021)

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Article Medicine, Research & Experimental

Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer

Jiaxin Chen et al.

Summary: circRHOBTB3 is downregulated in colorectal cancer tissues and cell lines, overexpression of circRHOBTB3 suppresses tumor metastasis through the HuR/PTBP1 axis in CRC.

THERANOSTICS (2021)

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Article Biotechnology & Applied Microbiology

ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism

Valentina Tassinari et al.

Summary: The study reveals that METTL3 methylates ADAR1 mRNA and increases its protein level, linking m6A and A-to-I editing and promoting glioblastoma growth. ADAR1 plays a crucial role in cancer progression and its knockdown can strongly inhibit glioblastoma growth.

GENOME BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

deepBase v3.0: expression atlas and interactive analysis of ncRNAs from thousands of deep-sequencing data

Fangzhou Xie et al.

Summary: The study updated deepBase to version 3.0, providing a comprehensive atlas of small RNAs and lncRNAs by integrating thousands of high-throughput sequencing data. Extracellular patterns of various ncRNAs were profiled for potential noninvasive biomarker discovery. Survival maps of tRFs, miRNAs, snoRNAs, and lncRNAs were constructed by analyzing cancer sample data, and interactive webs were developed to analyze differential expression and biological functions of various ncRNAs in different types of cancers.

NUCLEIC ACIDS RESEARCH (2021)

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Article Cell Biology

CircNOL10 suppresses breast cancer progression by sponging miR-767-5p to regulate SOCS2/JAK/STAT signaling

Fang Wang et al.

Summary: circNOL10 is down-regulated in breast cancer tissues and cells, and its low expression is associated with tumor size, TNM stage, lymph node metastasis, and poor prognosis. It acts as a sponge for miR-767-5p to up-regulate SOCS2 and inactivate the JAK2/STAT5 pathway, thereby repressing breast cancer development.

JOURNAL OF BIOMEDICAL SCIENCE (2021)

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Article Medicine, Research & Experimental

Circular RNA circDLC1 inhibits MMP1-mediated liver cancer via interaction with HuR

Hailing Liu et al.

Summary: Our study demonstrates that circDLC1 is downregulated in HCC tissues and is closely associated with a favorable prognosis. Overexpression of circDLC1 inhibits proliferation and motility of hepatoma cells, while silencing of circDLC1 has the opposite effect. Mechanistically, circDLC1 binds to RNA-binding protein HuR, reducing the interaction between HuR and MMP1 mRNA, leading to inhibition of MMP1 expression and ultimately suppressing HCC progression.

THERANOSTICS (2021)

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Review Cell Biology

The potential of using blood circular RNA as liquid biopsy biomarker for human diseases

Guoxia Wen et al.

Summary: CircRNA, a novel class of single-stranded RNAs with a closed loop structure, plays important biological functions in various physiological processes and is implicated in many human diseases. Human blood circRNAs as liquid biopsy biomarkers show promise due to their high stability and potential translational applications.

PROTEIN & CELL (2021)

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Review Biochemistry & Molecular Biology

CircRNA ciRS-7: a Novel Oncogene in Multiple Cancers

Junwen Chen et al.

Summary: ciRS-7, a type of circular RNA, plays a crucial role in regulating tumor progression by competitively inhibiting miR-7. It has been closely associated with various types of cancers, which makes its biological characteristics and molecular mechanisms worthy of further investigation.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Cell Biology

Circular RNA circHIPK3 modulates autophagy via MIR124-3p-STAT3-PRKAA/AMPKα signaling in STK11 mutant lung cancer

Xiuyuan Chen et al.

AUTOPHAGY (2020)

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Article Gastroenterology & Hepatology

A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma

Yanping Wei et al.

HEPATOLOGY (2020)

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Article Medicine, Research & Experimental

circAMOTL1 Motivates AMOTL1 Expression to Facilitate Cervical Cancer Growth

Rongying Ou et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Oncology

CircDUSP16 promotes the tumorigenesis and invasion of gastric cancer by sponging miR-145-5p

Zizhen Zhang et al.

GASTRIC CANCER (2020)

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Letter Oncology

Circ-RPL15: a plasma circular RNA as novel oncogenic driver to promote progression of chronic lymphocytic leukemia

Zijuan Wu et al.

LEUKEMIA (2020)

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Article Chemistry, Analytical

Direct detection of circRNA in real samples using reverse transcription-rolling circle amplification

Yaqian Liu et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Medicine, Research & Experimental

A novel circular RNA (hsa_circ_0000370) increases cell viability and inhibits apoptosis of FLT3-ITD-positive acute myeloid leukemia cells by regulating miR-1299 and S100A7A

Lingyan Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Oncology

Circular RNA circ-RanGAP1 regulates VEGFA expression by targeting miR-877-3p to facilitate gastric cancer invasion and metastasis

Jun Lu et al.

CANCER LETTERS (2020)

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Article Gastroenterology & Hepatology

Circular RNA Sequencing Identifies CircASAP1 as a Key Regulator in Hepatocellular Carcinoma Metastasis

Zhi-Qiang Hu et al.

HEPATOLOGY (2020)

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Article Biochemistry & Molecular Biology

Circular RNA ciRS-7 promotes tube formation in microvascular endothelial cells through downregulation of miR-26a-5p

Ming Cui et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2020)

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Article Medicine, Research & Experimental

Circ_0009910 promotes imatinib resistance through ULK1-induced autophagy by sponging miR-34a-5p in chronic myeloid leukemia

Hai-xia Cao et al.

LIFE SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Hsa_circ_001680 affects the proliferation and migration of CRC and mediates its chemoresistance by regulating BMI1 through miR-340

Xiangyu Jian et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer

Hongbao Yang et al.

MOLECULAR CANCER (2020)

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Review Biochemistry & Molecular Biology

Roles of circRNAs in the tumour microenvironment

Qiuge Zhang et al.

MOLECULAR CANCER (2020)

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Article Biotechnology & Applied Microbiology

circCAMSAP1 Promotes Tumor Growth in Colorectal Cancer via the miR-328-5p/E2F1 Axis

Chi Zhou et al.

MOLECULAR THERAPY (2020)

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Article Chemistry, Analytical

Electrochemical detection of circRNAs based on the combination of back-splice junction and duplex-specific nuclease

Jin Jiao et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Oncology

Circular RNA circ-MAT2B facilitates glycolysis and growth of gastric cancer through regulating the miR-515-5p/HIF-1α axis

Jia Liu et al.

CANCER CELL INTERNATIONAL (2020)

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Article Genetics & Heredity

ciRS-7 targeting miR-135a-5p promotes neuropathic pain in CCI rats via inflammation and autophagy

Wei Cai et al.

GENE (2020)

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Article Medicine, Research & Experimental

circRNA-AKT1 Sequesters miR-942-5p to Upregulate AKT1 and Promote Cervical Cancer Progression

Rongying Ou et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Medicine, Research & Experimental

Circular RNA circSLC26A4 Accelerates Cervical Cancer Progression via miR-1287-5p/HOXA7 Axis

Fei Ji et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Oncology

Circular RNA hsa_circ_0000326 acts as a miR-338-3p sponge to facilitate lung adenocarcinoma progression

Yuzhu Xu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Oncology

被撤回的出版物: The circular RNA 001971/miR-29c-3p axis modulates colorectal cancer growth, metastasis, and angiogenesis through VEGFA (Retracted article. See vol. 41, 2022)

Chen Chen et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Cell Biology

Circular RNA circNRIP1 promotes migration and invasion in cervical cancer by sponging miR-629-3p and regulating the PTP4A1/ERK1/2 pathway

Xinhui Li et al.

CELL DEATH & DISEASE (2020)

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Article Medicine, Research & Experimental

circFMN2 Sponges miR-1238 to Promote the Expression of LIM-Homeobox Gene 2 in Prostate Cancer Cells

Guangyi Shan et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Biochemistry & Molecular Biology

Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression

Gehao Liang et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis

Xiao-Yong Huang et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification

Mengmeng Jie et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

A novel protein encoded by circFNDC3B inhibits tumor progression and EMT through regulating Snail in colon cancer

Zihao Pan et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer

Xiaying Zheng et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

Circular RNA circCCDC9 acts as a miR-6792-3p sponge to suppress the progression of gastric cancer through regulating CAV1 expression

Zai Luo et al.

MOLECULAR CANCER (2020)

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Article Biotechnology & Applied Microbiology

The Circular RNA circSKA3 Binds Integrin β1 to Induce Invadopodium Formation Enhancing Breast Cancer Invasion

William W. Du et al.

MOLECULAR THERAPY (2020)

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Article Biochemistry & Molecular Biology

TRPC1 exacerbate metastasis in gastric cancer via ciRS-7/miR-135a-5p/TRPC1 axis

Zhiyong Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Oncology

CircRNA DONSON contributes to cisplatin resistance in gastric cancer cells by regulating miR-802/BMI1 axis

Yong Liu et al.

CANCER CELL INTERNATIONAL (2020)

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Review Oncology

Oral Manifestations and Complications in Childhood Acute Myeloid Leukemia

Francisco Cammarata-Scalisi et al.

CANCERS (2020)

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Article Oncology

Hsa_circ_0003998 promotes epithelial to mesenchymal transition of hepatocellular carcinoma by sponging miR-143-3p and PCBP1

Li-na Song et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Cell Biology

Down-regulated ciRS-7/up-regulated miR-7 axis aggravated Cartilage degradation and autophagy defection by PI3K/AKT/mTOR activation mediated by IL-17A in osteoarthritis

Xindie Zhou et al.

AGING-US (2020)

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Article Biochemistry & Molecular Biology

Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells

Nan Zhang et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation

Mengyan Xie et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p-TGF-β1 axis

Anquan Shang et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p

Jianfa Li et al.

MOLECULAR CANCER (2020)

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Article Oncology

CirculatingcircERBB2as a potential prognostic biomarker for gastric cancer: An investigative study

Kenji Nanishi et al.

CANCER SCIENCE (2020)

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Article Cell Biology

Circ-MMP2 (circ-0039411) induced by FOXM1 promotes the proliferation and migration of lung adenocarcinoma cells in vitro and in vivo

Xin Lv et al.

CELL DEATH & DISEASE (2020)

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Article Oncology

CircRNA hsa_circ_0002577 accelerates endometrial cancer progression through activating IGF1R/PI3K/Akt pathway

Yu Wang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Oncology

Circular RNA circ-CPA4/let-7 miRNA/PD-L1 axis regulates cell growth, stemness, drug resistance and immune evasion in non-small cell lung cancer (NSCLC)

Weijun Hong et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Oncology

Hsa_circ_0001944 promotes the growth and metastasis in bladder cancer cells by acting as a competitive endogenous RNA for miR-548

Mingming Jin et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Circular HER2 RNA positive triple negative breast cancer is sensitive to Pertuzumab

Jie Li et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

CircRNA inhibits DNA damage repair by interacting with host gene

Xiaolong Xu et al.

MOLECULAR CANCER (2020)

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Article Chemistry, Analytical

Ultrasensitive detection of circular RNA by accurate recognition of the specific junction site using stem-loop primer induced double exponential amplification

Pengbo Zhang et al.

TALANTA (2020)

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Review Neurosciences

Circular RNAs: The Brain Transcriptome Comes Full Circle

Akira Gokool et al.

TRENDS IN NEUROSCIENCES (2020)

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Article Medicine, Research & Experimental

circEYA1 Functions as a Sponge of miR-582-3p to Suppress Cervical Adenocarcinoma Tumorigenesis via Upregulating CXCL14

Junfen Xu et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Oncology

Hsa_circ_0012152 and Hsa_circ_0001857 Accurately Discriminate Acute Lymphoblastic Leukemia From Acute Myeloid Leukemia

Shanshan Guo et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Oncology

CircSOD2 induced epigenetic alteration drives hepatocellular carcinoma progression through activating JAK2/STAT3 signaling pathway

Zhongwei Zhao et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Oncology

CircRNA_0000392 promotes colorectal cancer progression through the miR-193a-5p/PIK3R3/AKT axis

Hanchen Xu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Oncology

被撤回的出版物: Circular RNA hsa_circ_0001829 promotes gastric cancer progression through miR-155-5p/SMAD2 axis (Retracted article. See vol. 42, 2023)

Qiuling Niu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Oncology

Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression

Guangli Sun et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Oncology

A novel circular RNA circ-LRIG3 facilitates the malignant progression of hepatocellular carcinoma by modulating the EZH2/STAT3 signaling

Suofeng Sun et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Cell Biology

CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/β-catenin pathway

Guanqun Huang et al.

CELL DEATH & DISEASE (2020)

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Article Cell Biology

A novel circular RNA, circXPO1, promotes lung adenocarcinoma progression by interacting with IGF2BP1

Qi Huang et al.

CELL DEATH & DISEASE (2020)

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Article Medicine, Research & Experimental

circFN1 Mediates Sorafenib Resistance of Hepatocellular Carcinoma Cells by Sponging miR-1205 and Regulating E2F1 Expression

Cheng Yang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Medicine, Research & Experimental

circNR3C1 Suppresses Bladder Cancer Progression through Acting as an Endogenous Blocker of BRD4/C-myc Complex

Fei Xie et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Review Biotechnology & Applied Microbiology

The role of circular RNAs in hematological malignancies

Zhi Lin et al.

GENOMICS (2020)

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Article Biochemistry & Molecular Biology

circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2

Lei Peng et al.

MOLECULAR CANCER (2020)

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Article Medicine, Research & Experimental

circPTCH1 promotes invasion and metastasis in renal cell carcinoma via regulating miR-485-5p/MMP14 axis

Huan Liu et al.

THERANOSTICS (2020)

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Article Chemistry, Organic

Direct recognition and sensitive detection of circular RNA with ligation-based PCR

Pengbo Zhang et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2020)

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Article Biotechnology & Applied Microbiology

CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes

Wanying Wu et al.

GENOME BIOLOGY (2020)

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Article Medicine, Research & Experimental

circPRRC2A promotes angiogenesis and metastasis through epithelial-mesenchymal transition and upregulates TRPM3 in renal cell carcinoma

Wei Li et al.

THERANOSTICS (2020)

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Article Biochemical Research Methods

Microarray is an efficient tool for circRNA profiling

Shasha Li et al.

BRIEFINGS IN BIOINFORMATICS (2019)

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Article Biochemical Research Methods

TRCirc: a resource for transcriptional regulation information of circRNAs

Zhidong Tang et al.

BRIEFINGS IN BIOINFORMATICS (2019)

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Article Biochemistry & Molecular Biology

The Landscape of Circular RNA in Cancer

Josh N. Vo et al.

CELL (2019)

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Article Oncology

CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth

Liangliang Xu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway

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MOLECULAR CANCER (2019)

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Article Biochemistry & Molecular Biology

被撤回的出版物: CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p (Retracted article. See vol. 22, 2023)

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MOLECULAR CANCER (2019)

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Article Biochemistry & Molecular Biology

Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation o transcription factor SOX4

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MOLECULAR CANCER (2019)

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A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling

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MOLECULAR CANCER (2019)

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Article Oncology

CircSMARCA5 Regulates VEGFA mRNA Splicing and Angiogenesis in Glioblastoma Multiforme Through the Binding of SRSF1

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CANCERS (2019)

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Review Cell Biology

Exosome-Mediated Metastasis: Communication from a Distance

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Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626/EYA4 axis

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MOLECULAR CANCER (2019)

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Molecular determinants of metazoan tricRNA biogenesis

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NUCLEIC ACIDS RESEARCH (2019)

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RNA BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN

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MOLECULAR CANCER (2019)

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Review Medicine, Research & Experimental

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MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

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JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Circular RNA circ-ZKSCAN1 inhibits bladder cancer progression through miR-1178-3p/p21 axis and acts as a prognostic factor of recurrence

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MOLECULAR CANCER (2019)

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Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation

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MOLECULAR CANCER (2019)

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Article Biochemistry & Molecular Biology

Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes

Yajun Chen et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Article Biochemistry & Molecular Biology

Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer

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MOLECULAR CANCER (2019)

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Article Biochemistry & Molecular Biology

hsa_circRNA_0006528 as a competing endogenous RNA promotes human breast cancer progression by sponging miR-7-5p and activating the MAPK/ERK signaling pathway

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MOLECULAR CARCINOGENESIS (2019)

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Article Cell Biology

The novel circCLK3/miR-320a/FoxM1 axis promotes cervical cancer progression

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CELL DEATH & DISEASE (2019)

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Review Medicine, General & Internal

Circular RNA: a novel biomarker and therapeutic target for human cancers

Bo Lei et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2019)

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exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes

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NUCLEIC ACIDS RESEARCH (2018)

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Circ-UBR5: An exonic circular RNA and novel small nuclear RNA involved in RNA splicing

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Editorial Material Cell Biology

Size matters: conserved proteins function in length-dependent nuclear export of circular RNAs

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Carcinoembryonic Antigen for Diagnosis of Colorectal Cancer Recurrence

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

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Letter Cell Biology

circRNA disease: a manually curated database of experimentally supported circRNA-disease associations

Zheng Zhao et al.

CELL DEATH & DISEASE (2018)

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CircR2Disease: a manually curated database for experimentally supported circular RNAs associated with various diseases

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DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2018)

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EIciRNA-mediated gene expression: tunability and bimodality

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FEBS LETTERS (2018)

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CIRCpedia v2: An Updated Database for Comprehensive Circular RNA Annotation and Expression Comparison

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GENOMICS PROTEOMICS & BIOINFORMATICS (2018)

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Application of droplet digital PCR in quantitative detection of the cell-free circulating circRNAs

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BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT (2018)

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Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses

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EUROPEAN HEART JOURNAL (2017)

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Translation of CircRNAs

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MOLECULAR CELL (2017)

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Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

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FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

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The circRNA interactome-innovative hallmarks of the intra- and extracellular radiation response

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ONCOTARGET (2017)

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circlncRNAnet: an integrated web-based resource for mapping functional networks of long or circular forms of noncoding RNAs

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GIGASCIENCE (2017)

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Extensive translation of circular RNAs driven by N6-methyladenosine

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CELL RESEARCH (2017)

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CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs

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RNA BIOLOGY (2016)

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Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

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NUCLEIC ACIDS RESEARCH (2016)

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circRNADb: A comprehensive database for human circular RNAs with protein-coding annotations

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SCIENTIFIC REPORTS (2016)

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The RNA Binding Protein Quaking Regulates Formation of circRNAs

Simon J. Conn et al.

CELL (2015)

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Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

Yan Li et al.

CELL RESEARCH (2015)

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Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

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MOLECULAR CELL (2015)

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Exon-intron circular RNAs regulate transcription in the nucleus

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Exon-intron circular RNAs regulate transcription in the nucleus

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Complementary Sequence-Mediated Exon Circularization

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A View of Pre-mRNA Splicing from RNase R Resistant RNAs

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circRNA Biogenesis Competes with Pre-mRNA Splicing

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starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data

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NUCLEIC ACIDS RESEARCH (2014)

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circBase: a database for circular RNAs

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RNA (2014)

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Circular Intronic Long Noncoding RNAs

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MOLECULAR CELL (2013)

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Natural RNA circles function as efficient microRNA sponges

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NATURE (2013)

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Circular RNAs are a large class of animal RNAs with regulatory potency

Sebastian Memczak et al.

NATURE (2013)

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Circular RNAs are abundant, conserved, and associated with ALU repeats

William R. Jeck et al.

RNA (2013)

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Frontiers in Genetics (2013)

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Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

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CELL (2010)

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RNA-binding proteins: modular design for efficient function

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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

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