Journal
FRONTIERS IN ONCOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.836397
Keywords
photodynamic therapy; photosensitizer; nanotechnology; nanoparticle; nonmelanoma skin cancer; metastatic melanoma
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Funding
- National Natural Science Foundation of China [81803157]
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Comprehensive cancer treatments, including traditional methods and nanotech-PDT, have been widely researched. Nanotech-based PDT offers improved targeting and efficacy for tumors, showing potential in the treatment of non-melanoma skin cancer and melanoma.
Comprehensive cancer treatments have been widely studied. Traditional treatment methods (e.g., radiotherapy, chemotherapy), despite ablating tumors, inevitably damage normal cells and cause serious complications. Photodynamic therapy (PDT), with its low rate of trauma, accurate targeting, synergism, repeatability, has displayed great advantages in the treatment of tumors. In recent years, nanotech-based PDT has provided a new modality for cancer treatment. Direct modification of PSs by nanotechnology or the delivery of PSs by nanocarriers can improve their targeting, specificity, and PDT efficacy for tumors. In this review, we strive to provide the reader with a comprehensive overview, on various aspects of the types, characteristics, and research progress of photosensitizers and nanomaterials used in PDT. And the application progress and relative limitations of nanotech-PDT in non-melanoma skin cancer and melanoma are also summarized.
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