Journal
FRONTIERS IN ONCOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.860508
Keywords
caffeic acid; clinical trials; diabetic neuropathy; inflammatory diseases; inhibitors; targeted therapy
Categories
Funding
- Indian Council of Medical Research [45/6/2020-DDI/BMS]
- [DSR-2021-01-0368]
- [SR/FST/LSII/2020/782]
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Caffeic acid (CA) is a substance found in various foods and beverages, with biological activities such as antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. Its potential therapeutic effects are mediated through the repression and inhibition of transcription and growth factors. The biomolecular interactions and pathways of CA have been described.
Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA and its derivatives have been used for many centuries due to their natural healing and medicinal properties. CA possesses various biological and pharmacological activities, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. The potential therapeutic effects of CA are mediated via repression and inhibition of transcription and growth factors. CA possesses potential anticancer and neuroprotective effects in human cell cultures and animal models. However, the biomolecular interactions and pathways of CA have been described highlighting the target binding proteins and signaling molecules. The current review focuses on CA's chemical, physical, and pharmacological properties, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. We further described CA's characteristics and therapeutic potential and its future directions.
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