4.6 Article

Single-Cell Proteomics and Tumor RNAseq Identify Novel Pathways Associated With Clofazimine Sensitivity in PI- and IMiD- Resistant Myeloma, and Putative Stem-Like Cells

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

Shuofeng Yuan et al.

Summary: The anti-leprosy drug clofazimine has shown inhibitory activity against various coronaviruses, reducing viral loads in the lung and shedding, as well as alleviating inflammation. Combination with remdesivir exhibited antiviral synergy, suggesting potential for treating COVID-19 patients, particularly in resource-limited settings.

NATURE (2021)

Review Oncology

Multiple Myeloma: Heterogeneous in Every Way

Anais Schavgoulidze et al.

Summary: Prognosis stratification is crucial for treatment choice in multiple myeloma, but current scores based on biochemical parameters and cytogenetics are imperfect. Cytogenetics and minimal residual disease have a major impact on prognosis, but fail to explain all the heterogeneity in outcomes.

CANCERS (2021)

Article Medicine, General & Internal

Cost-effectiveness of Novel Treatment Sequences for Transplant-Ineligible Patients With Multiple Myeloma

Hedwig M. Blommestein et al.

Summary: This study found that treatment sequences starting with daratumumab-VMP or VMPT-VT led to the best overall survival and cost-effectiveness in elderly non-transplant-eligible multiple myeloma patients. It suggests that incorporating novel treatments may be highly effective but may require cost negotiation to be more economically feasible.

JAMA NETWORK OPEN (2021)

Review Oncology

Identification and Characterization of Multiple Myeloma Stem Cell-Like Cells

Wancheng Guo et al.

Summary: This paper systematically summarizes the latest developments in multiple myeloma stem cells, including possible markers of MMSCs, introduces the mechanism of how MMSCs work in MM resistance and recurrence, and discusses the active pathways related to stemness of MM.

CANCERS (2021)

Article Oncology

Direct to Drug screening as a precision medicine tool in multiple myeloma

Cecilia Bonolo de Campos et al.

BLOOD CANCER JOURNAL (2020)

Review Oncology

Molecular functions of brain expressed X-linked 2 (BEX2) in malignancies

Ali Naderi

EXPERIMENTAL CELL RESEARCH (2019)

Article Biochemistry & Molecular Biology

Disulfiram/copper targets stem cell-like ALDH+ population of multiple myeloma by inhibition of ALDH1A1 and Hedgehog pathway

Na Jin et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Article Medicine, Research & Experimental

Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma

Anna Bianchi-Smiraglia et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Review Medicine, General & Internal

Modern multiple myeloma therapy: deep, sustained treatment response and good clinical outcomes

O. Landgren et al.

JOURNAL OF INTERNAL MEDICINE (2017)

Article Hematology

Myeloma today: Disease definitions and treatment advances

S. Vincent Rajkumar

AMERICAN JOURNAL OF HEMATOLOGY (2016)

Article Medicine, General & Internal

Multiple Myeloma: Diagnosis and Treatment

S. Vincent Rajkumar et al.

MAYO CLINIC PROCEEDINGS (2016)

Article Biochemistry & Molecular Biology

Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis

Zhongdong Hu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biochemical Research Methods

Causal analysis approaches in Ingenuity Pathway Analysis

Andreas Kraemer et al.

BIOINFORMATICS (2014)

Review Hematology

Multiple myeloma: 2013 update on diagnosis, risk-stratification, and management

S. Vincent Rajkumar

AMERICAN JOURNAL OF HEMATOLOGY (2013)

Review Biochemistry & Molecular Biology

Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress

Shane Deegan et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

Article Oncology

New Strategies in the Treatment of Multiple Myeloma

Nikhil C. Munshi et al.

CLINICAL CANCER RESEARCH (2013)

Review Infectious Diseases

Systematic review of clofazimine for the treatment of drug-resistant tuberculosis

M. Gopal et al.

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2013)

Article Medicine, Research & Experimental

Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells

Luigi Leanza et al.

EMBO MOLECULAR MEDICINE (2012)

Review Hematology

Genetic variations in multiple myeloma II: association with effect of treatment

Annette Vangsted et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2012)

Review Infectious Diseases

Clofazimine: current status and future prospects

Moloko C. Cholo et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2012)

Review Medicine, Research & Experimental

Molecular pathogenesis of multiple myeloma and its premalignant precursor

W. Michael Kuehl et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Review Oncology

Multiple myeloma cancer stem cells

Carol Ann Huff et al.

JOURNAL OF CLINICAL ONCOLOGY (2008)

Letter Oncology

Presence of Hoechst low side populations in multiple myeloma

Yen S. Loh et al.

LEUKEMIA & LYMPHOMA (2008)

Article Multidisciplinary Sciences

Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma

M. E. Prince et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Biochemistry & Molecular Biology

Mediators of endoplasmic reticulum stress-induced apoptosis

Eva Szegezdi et al.

EMBO REPORTS (2006)

Article Hematology

Characterization of clonogenic multiple myeloma cells

W Matsui et al.

BLOOD (2004)