4.6 Review

Can Natural Products be Used to Overcome the Limitations of Colorectal Cancer Immunotherapy?

Journal

FRONTIERS IN ONCOLOGY
Volume 12, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.884423

Keywords

colorectal cancer; immunotherapy; immune checkpoint inhibitor; natural products; immunomodulation

Categories

Funding

  1. National Nature Science Foundation of China [81874206, 82104466]
  2. Shanghai Frontiers Science Center of Disease and Syndrome Biology of Inflammatory Cancer Transformation [2021KJ03-12]
  3. Shanghai Rising-Star Program [20QA1409300]
  4. Program for Young Eastern Scholar at Shanghai Institutions of Higher Learning [QD2019034]

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Colorectal cancer is a common cancer that poses a threat to human health. Immunotherapy is widely used in cancer treatment, but most colorectal cancer patients are not responsive to it. Therefore, developing an effective combination therapy is a goal in cancer research. Natural products, with their diverse immunomodulatory effects, have the potential to be used in comprehensive cancer treatment options.
Colorectal cancer (CRC) is a common cancer of the digestive system that endangers human health. Immunotherapy is widely used in the treatment of patients with cancer. Some patients with dMMR/MSI-H CRC benefit from treatments that use immune checkpoint inhibitors, but most CRC patients are not sensitive to immunotherapy. Furthermore, internal resistance and immune escape lead to a reduced immunotherapy response. Therefore, the development of an effective combination therapy to improve the response rate to immunotherapy is a goal of cancer research. Natural products are potential candidates for comprehensive cancer treatments due to their wide range of immunomodulatory effects through multifactorial underlying mechanisms. In this review, we summarize the challenges in the treatment of CRC and assess the immunomodulatory effects of natural products and their active components. Our work suggests that natural products represent potential options for combined CRC immunotherapy.

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