Journal
FRONTIERS IN ONCOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.887244
Keywords
gastric cancer; transcription factor; immune microenvironment; immunogenicity; immunotherapy transcription factor; immunotherapy
Categories
Funding
- third round of public welfare development and reform pilot projects of Beijing Municipal Medical Research Institutes (Beijing Medical Research Institute) [2019-1]
- National Natural Science Foundation of China [U20A20371, 81872502, 81802471, 81972758, 82073312]
- National High Technology Research and Development Program of China (863 Program) [2014AA020603]
- Double First Class disciplinary development Foundation of Peking University [BMU2019LCKXJ011]
- Capital's funds for health improvement and research [2018-2-1023]
- Beijing municipal administration of hospitals'youth program [QML20181102]
- Beijing Municipal Administration of Hospitals Incubating Program [PX2019040]
- Research Fund for Young Scholars of Beijing [2018000021469G265]
- Clinical Medicine Plus X-Young Scholars Project
- Peking University (the Fundamental Research Funds for the Central Universities) [PKU2020LCXQ001]
- Science Foundation of Peking University Cancer Hospital [2020-6, 2020-22]
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Assessment of immune-related transcription factor (IRTF) regulation patterns in gastric cancer patients can enhance our understanding of immune specificities and provide effective strategies for personalized therapy.
BackgroundTranscription factors (TFs) play a crucial role in tumorigenesis and anti-tumor immunity. However, the potential role of large-scale transcription factor regulation patterns in the progression in gastric cancer (GC) is unknown. MethodsWe comprehensively assessed the relevance of immune-related TF (IRTF) regulation patterns in anti-tumor immunity and immunotherapy in 1,136 gastric cancer (GC) patients, and evaluated the IRTF score based on IRTF regulation patterns using random forests. ResultsTwo distinct IRTF regulation patterns were identified, which demonstrating the distinct characteristics in clinical phenotypes, tumor immune microenvironment (TIME), immunogenicity and prognosis in GC. Subsequently, the IRTF score was established to quantify the IRTF regulation pattern for each GC patient. Analysis of large conventional therapy cohorts showed low IRTF score was associated with a better prognosis. In addition, analysis of multiple immunotherapy cohorts showed low IRTF score was also linked to enhanced response to immunotherapy. ConclusionTF regulation patterns were found to play an important role in the complex immune regulatory relationships in GC. Evaluation of the IRTF regulation patterns in patients will enhance our understanding of immune specificities, and thus, provide effective strategies for personalized therapy.
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