Journal
FRONTIERS IN ONCOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.822085
Keywords
glioblastoma; macrophage; microglia; signal pathway; interaction; therapeutic targets
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Glioblastoma is a complex tumor comprised of neoplastic and non-neoplastic cells, with tumor-associated macrophages playing crucial roles in tumor progression. The interactions between tumor cells and TAMs result in an immunosuppressive and tumor-supportive microenvironment. Understanding these interactions can lead to potential therapeutic targets for glioblastoma.
It is commonly recognized, that glioblastoma is a large complex composed of neoplastic and non-neoplastic cells. Tumor-associated macrophages account for the majority of tumor bulk and play pivotal roles in tumor proliferation, migration, invasion, and survival. There are sophisticated interactions between malignant cells and tumor associated-macrophages. Tumor cells release a variety of chemokines, cytokines, and growth factors that subsequently lead to the recruitment of TAMs, which in return released a plethora of factors to construct an immunosuppressive and tumor-supportive microenvironment. In this article, we have reviewed the biological characteristics of glioblastoma-associated macrophages and microglia, highlighting the emerging molecular targets and related signal pathways involved in the interaction between TAMs and glioblastoma cells, as well as the potential TAMs-associated therapeutic targets for glioblastoma.
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