Journal
CELLS
Volume 11, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/cells11081283
Keywords
adult neural stem; progenitor cells; proliferation; differentiation; NAD plus; Akt pathway
Categories
Funding
- National Key Research and Development Program of China [2017YFE0196600]
- National Natural Science Foundation of China [92049108]
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Nicotinamide adenine dinucleotide hydrate (NAD+) plays a crucial role in regulating adult neural stem/progenitor cells (aNSPCs) by reducing proliferation, neuronal differentiation, and inducing apoptosis. NAD+ exposure also inhibits neuronal morphological development. Mechanistically, NAD+ exposure alters transcriptome and decreases the expression of genes related to ATP metabolism and the PI3k-Akt signaling pathway.
Nicotinamide adenine dinucleotide hydrate (NAD+) acts as the essential component of the tricarboxylic citric acid (TCA) cycle and has important functions in diverse biological processes. However, the roles of NAD+ in regulating adult neural stem/progenitor cells (aNSPCs) remain largely unknown. Here, we show that NAD+ exposure leads to the reduced proliferation and neuronal differentiation of aNSPCs and induces the apoptosis of aNSPCs. In addition, NAD+ exposure inhibits the morphological development of neurons. Mechanistically, RNA sequencing revealed that the transcriptome of aNSPCs is altered by NAD+ exposure. NAD+ exposure significantly decreases the expression of multiple genes related to ATP metabolism and the PI3k-Akt signaling pathway. Collectively, our findings provide some insights into the roles and mechanisms in which NAD+ regulates aNSPCs and neuronal development.
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