4.6 Article

Hsp70 in Redox Homeostasis

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Molecular mechanisms of heat shock factor 1 regulation

Szymon W. Kmiecik et al.

Summary: Cells need to maintain proteome homeostasis and regulate it through the heat shock response (HSR), which is orchestrated by heat shock transcription factor 1 (Hsf1). Hsf1 plays a crucial role in regulating proteome homeostasis and is involved in aging, cancer, and neurodegenerative disorders. Multiple layers of control circuits, such as synthesis and degradation, conformational rearrangements, post translational modifications (PTMs), and molecular chaperones in negative feedback loops, regulate the transcriptional activity of Hsf1.

TRENDS IN BIOCHEMICAL SCIENCES (2022)

Article Biochemical Research Methods

iCysMod: an integrative database for protein cysteine modifications in eukaryotes

Panqin Wang et al.

Summary: The iCysMod database was developed to provide an integrative resource for protein cysteine modifications in eukaryotes, curating over 108,000 PCM events. The database offers browse and search options for accessing the dataset, along with detailed information organized for visualization. The dataset includes information on 8 types of PCMs and analysis of sequence features around cysteine modification sites for each type, showing distinct preferences for sequence recognition.

BRIEFINGS IN BIOINFORMATICS (2021)

Article Biochemistry & Molecular Biology

Mutational analysis of the Hsp70 substrate-binding domain: Correlating molecular-level changes with in vivo function

Linan Xu et al.

Summary: Hsp70 is a conserved chaperone that plays a critical role in maintaining protein homeostasis. Mutations in the SBD disrupt its hydrophobic core, leading to impairment of heat-shock response and prion propagation. The disruption of key residues in the SBD region results in instability and cleavage of Hsp70, impacting its ATPase function and overall stability. This ultimately compromises the stress response and prion propagation abilities of yeast cells.

MOLECULAR MICROBIOLOGY (2021)

Article Biochemistry & Molecular Biology

Lipid peroxidation in brain tumors

Morana Jaganjac et al.

Summary: Evidence suggests lipid peroxidation is crucial in disease development, with 4-HNE acting as a key factor. 4-HNE affects blood-brain barrier functionality by forming stable protein adducts. Further research is needed on the role of 4-HNE in carcinogenesis and tumor defense.

NEUROCHEMISTRY INTERNATIONAL (2021)

Review Cell Biology

Heat Shock Proteins in Oxidative Stress and Ischemia/Reperfusion Injury and Benefits from Physical Exercises: A Review to the Current Knowledge

Jakub Szyller et al.

Summary: The research focuses on the regulatory role of heat shock proteins (HSPs) in oxidative stress and ischemia/reperfusion injury, as well as their relationship with reactive oxygen species (ROS) and antioxidant systems. Understanding the mechanisms involved is crucial for the development of treatment methods.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Multidisciplinary Sciences

On the evolution of chaperones and cochaperones and the expansion of proteomes across the Tree of Life

Mathieu E. Rebeaud et al.

Summary: As life evolved along the Tree of Life, the number and size of proteins in proteomes from archaea to mammals increased significantly, with new proteins and combinations of protein folds arising. To maintain quality control, core chaperones and emerging co-chaperones cooperatively evolved into a network to support the massive expansion of proteomes.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Cell Biology

Involvement of 4-hydroxy-2-nonenal in the pathogenesis of pulmonary fibrosis

Edilburga Reyes-Jimenez et al.

Summary: Pulmonary fibrosis is a chronic progressive disease with high incidence rates worldwide. Oxidative stress, characterized by overproduction of 4-HNE, plays an important role in the pathogenesis of pulmonary fibrosis, with complex cellular and molecular mechanisms involved.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Conformational equilibria in allosteric control of Hsp70 chaperones

Wei Wang et al.

Summary: Researchers characterized biochemical properties of selected domain-interface mutants in bacterial Hsp70 DnaK and developed a theoretical model to explain allosteric equilibria among Hsp70 conformational states. They proposed a restraining state and a stimulating state to describe the different characteristics of Hsp70 in ATP hydrolysis and peptide binding.

MOLECULAR CELL (2021)

Article Biochemistry & Molecular Biology

Direct Proteomic Mapping of Cysteine Persulfidation

Ling Fu et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

Review Biochemistry & Molecular Biology

Mechanisms and consequences of protein cysteine oxidation: the role of the initial short-lived intermediates

Lucia Turell et al.

PROTEIN OXIDATION (2020)

Article Biochemistry & Molecular Biology

S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal ?-helical lid

Jie Yang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

Kinetics of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function

Si Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Hsc70/Stub1 promotes the removal of individual oxidatively stressed peroxisomes

Bo-Hua Chen et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

HSP40 proteins use class-specific regulation to drive HSP70 functional diversity

Ofrah Faust et al.

NATURE (2020)

Review Cell Biology

The Hsp70 chaperone network

Rina Rosenzweig et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Medicine, Research & Experimental

4-HNE Induces Apoptosis of Human Retinal Pigment Epithelial Cells by Modifying HSP70

Lei-lei Yang et al.

CURRENT MEDICAL SCIENCE (2019)

Article Multidisciplinary Sciences

Structural basis for client recognition and activity of Hsp40 chaperones

Yajun Jiang et al.

SCIENCE (2019)

Review Biochemistry & Molecular Biology

Biochemical basis and metabolic interplay of redox regulation

Lixiao Zhang et al.

REDOX BIOLOGY (2019)

Review Oncology

PI3K/Akt signaling transduction pathway, erythropoiesis and glycolysis in hypoxia

Youbang Xie et al.

MOLECULAR MEDICINE REPORTS (2019)

Review Biochemistry & Molecular Biology

Regulation of redox balance in cancer and T cells

Hyewon Kong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Functional and physical interaction between yeast Hsp90 and Hsp70

Andrea N. Kravats et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

The C-terminal GGAP motif of Hsp70 mediates substrate recognition and stress response in yeast

Weibin Gong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Chemical proteomics reveals new targets of cysteine sulfinic acid reductase

Salma Akter et al.

NATURE CHEMICAL BIOLOGY (2018)

Article Multidisciplinary Sciences

Allosteric landscapes of eukaryotic cytoplasmic Hsp70s are shaped by evolutionary tuning of key interfaces

Wenli Meng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

The β6/β7 region of the Hsp70 substrate-binding domain mediates heat-shock response and prion propagation

Linan Xu et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

Article Cell Biology

STAT3 activation in infection and infection-associated cancer

Rong Lu et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2017)

Review Biochemistry & Molecular Biology

Proteostasis, oxidative stress and aging

Ioanna Korovila et al.

REDOX BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Redox dynamics of manganese as a mitochondrial life-death switch

Matthew Ryan Smith et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Review Biochemical Research Methods

The Expanding Landscape of the Thiol Redox Proteome

Jing Yang et al.

MOLECULAR & CELLULAR PROTEOMICS (2016)

Article Cell Biology

4-Hydroxy-2-nonenal: a critical target in oxidative stress?

Mason Breitzig et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2016)

Review Cell Biology

The human HSP70 family of chaperones: where do we stand?

Jurgen Radons

CELL STRESS & CHAPERONES (2016)

Review Chemistry, Medicinal

Function and Chemotypes of Human Hsp70 Chaperones

Liza Shrestha et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)

Review Biochemistry & Molecular Biology

Redox signaling: An evolution from free radicals to aging

Henry Jay Forman

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Biochemistry & Molecular Biology

The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome

Sandra Reeg et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Biochemistry & Molecular Biology

Formation and Reversibility of BiP Protein Cysteine Oxidation Facilitate Cell Survival during and post Oxidative Stress

Jie Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response

Hong Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Cell Biology

Ferrootosis: Death by Lipid Peroxidation

Wan Seok Yang et al.

TRENDS IN CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Oxidative stress-mediated antimalarial activity of plakortin, a natural endoperoxide from the tropical sponge Plakortis simplex

Oleksii A. Skorokhod et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

Article Multidisciplinary Sciences

Substrate-binding domain conformational dynamics mediate Hsp70 allostery

Anastasia Zhuravleva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Pharmacology & Pharmacy

Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

Sharadha Dayalan Naidu et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2015)

Review Biochemistry & Molecular Biology

Oxidative stress: a concept in redox biology and medicine

Helmut Sies

REDOX BIOLOGY (2015)

Review Biochemistry & Molecular Biology

The nucleotide exchange factors of Hsp70 molecular chaperones

Andreas Bracher et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2015)

Article Physiology

Inducible HSP70 regulates superoxide dismutase-2 and mitochondrial oxidative stress in the endothelial cells from developing lungs

Adeleye J. Afolayan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2014)

Article Biochemical Research Methods

dbGSH: a database of S-glutathionylation

Yi-Ju Chen et al.

BIOINFORMATICS (2014)

Article Cell Biology

The oxidation of HSP70 is associated with functional impairment and lack of stimulatory capacity

Marcelo Sartori Grunwald et al.

CELL STRESS & CHAPERONES (2014)

Review Cardiac & Cardiovascular Systems

An overview of mechanisms of redox signaling

Henry Jay Forman et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2014)

Review Cell Biology

Cellular mechanisms and physiological consequences of redox-dependent signalling

Kira M. Holmstroem et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Multidisciplinary Sciences

Site-specific mapping and quantification of protein S-sulphenylation in cells

Jing Yang et al.

NATURE COMMUNICATIONS (2014)

Review Biochemistry & Molecular Biology

Hydrogen peroxide sensing, signaling and regulation of transcription factors

H. Susana Marinho et al.

REDOX BIOLOGY (2014)

Review Biochemistry & Molecular Biology

The fairytale of the GSSG/GSH redox potential

Leopold Flohe

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)

Review Oncology

The HSP70 family and cancer

Maureen E. Murphy

CARCINOGENESIS (2013)

Article Cell Biology

A delayed antioxidant response in heat-stressed cells expressing a non-DNA binding HSF1 mutant

Sanne M. M. Hensen et al.

CELL STRESS & CHAPERONES (2013)

Review Biochemistry & Molecular Biology

Cellular metabolic and autophagic pathways: Traffic control by redox signaling

Matthew Dodson et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Article Biochemistry & Molecular Biology

Endoplasmic Reticulum Protein Quality Control Is Determined by Cooperative Interactions between Hsp/c70 Protein and the CHIP E3 Ligase

Yoshihiro Matsumura et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP

Ruifeng Qi et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)

Article Biochemical Research Methods

RedoxDB-a curated database for experimentally verified protein oxidative modification

Ming-an Sun et al.

BIOINFORMATICS (2012)

Article Biochemistry & Molecular Biology

Cysteine Reactivity Distinguishes Redox Sensing by the Heat-Inducible and Constitutive Forms of Heat Shock Protein 70

Yoshinari Miyata et al.

CHEMISTRY & BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

Roman Kityk et al.

MOLECULAR CELL (2012)

Article Cell Biology

SNObase, a database for S-nitrosation modification

Xu Zhang et al.

PROTEIN & CELL (2012)

Article Biochemistry & Molecular Biology

HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

Ying Zhang et al.

CHEMISTRY & BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Conserved, Disordered C Terminus of DnaK Enhances Cellular Survival upon Stress and DnaK in Vitro Chaperone Activity

Robert G. Smock et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Review Cell Biology

Signal transduction by reactive oxygen species

Toren Finkel

JOURNAL OF CELL BIOLOGY (2011)

Article Multidisciplinary Sciences

Allosteric signal transmission in the nucleotide-binding domain of 70-kDa heat shock protein (Hsp70) molecular chaperones

Anastasia Zhuravleva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Medicine, Research & Experimental

Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus

Omur Tabak et al.

CLINICAL AND INVESTIGATIVE MEDICINE (2011)

Article Biochemistry & Molecular Biology

Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling

Pankaj Chaudhary et al.

BIOCHEMISTRY (2010)

Article Biochemistry & Molecular Biology

CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates

Marta Stankiewicz et al.

FEBS JOURNAL (2010)

Article Multidisciplinary Sciences

Quantitative reactivity profiling predicts functional cysteines in proteomes

Eranthie Weerapana et al.

NATURE (2010)

Review Pharmacology & Pharmacy

Induction of heat shock proteins for protection against oxidative stress

Bernadett Kalmar et al.

ADVANCED DRUG DELIVERY REVIEWS (2009)

Article Biochemistry & Molecular Biology

Chaperones and protein folding in the archaea

Andrew T. Large et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2009)

Article Cardiac & Cardiovascular Systems

Shear flow increases S-nitrosylation of proteins in endothelial cells

Bin Huang et al.

CARDIOVASCULAR RESEARCH (2009)

Article Endocrinology & Metabolism

Overexpression of mitochondrial Hsp70/Hsp75 in rat brain protects mitochondria, reduces oxidative stress, and protects from focal ischemia

Lijun Xu et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2009)

Article Multidisciplinary Sciences

Oxidative Stress Impairs the Heat Stress Response and Delays Unfolded Protein Recovery

Masaaki Adachi et al.

PLOS ONE (2009)

Article Multidisciplinary Sciences

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

Eric B. Bertelsen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding

Sigrun Polier et al.

Review Biochemistry & Molecular Biology

Multiple Hsp70 isoforms in the eukaryotic cytosol: Mere redundancy or functional specificity?

Mehdi Kabani et al.

CURRENT GENOMICS (2008)

Article Medicine, Research & Experimental

Role of heat shock proteins HSP70 and HSP32 in the protective effect of adaptation of cultured HT22 hippocampal cells to oxidative stress

I. P. Khomenko et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2007)

Review Cell Biology

Chaperone-mediated autophagy

J. Fred Dice

AUTOPHAGY (2007)

Article Biochemistry & Molecular Biology

Involvement of heat shock protein-70 in the mechanism of hydrogen peroxide-induced DNA damage: The role of lysosomes and iron

Paschalis-Thomas Doulias et al.

FREE RADICAL BIOLOGY AND MEDICINE (2007)

Review Biochemistry & Molecular Biology

The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones

X-B. Qiu et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2006)

Review Biochemical Research Methods

Redox proteomics: identification and functional role of glutathionylated proteins

M Fratelli et al.

EXPERT REVIEW OF PROTEOMICS (2004)

Article Multidisciplinary Sciences

The 70-kDa heat shock protein chaperone nucleotide-binding domain in solution unveiled as a molecular machine that can reorient its functional subdomains

YB Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Chemistry, Medicinal

Inhibition of Hsp72-mediated protein refolding by 4-hydroxy-2-nonenal

DL Carbone et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2004)

Article Cell Biology

Activation of chaperone-mediated autophagy during oxidative stress

R Kiffin et al.

MOLECULAR BIOLOGY OF THE CELL (2004)

Article Hematology

Reactive oxygen species regulate heat-shock protein 70 via the JAK/STAT pathway

NR Madamanchi et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2001)