4.6 Review

Insulin-Degrading Enzyme, an Under-Estimated Potential Target to Treat Cancer?

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Modified natriuretic peptides and their potential roles in cancer treatment

Mengjiao Xu et al.

Summary: This review introduces the natriuretic peptide family and its relationship with cancer, discusses the inhibitory effects and anti-cancer mechanisms of natriuretic peptides on tumor growth, and introduces methods for modifying natriuretic peptides to enhance stability and biological effects. Natriuretic peptides have significant potential for clinical application in cancer treatment.

BIOMEDICAL JOURNAL (2022)

Article Oncology

Identification of a Prognostic Signature Based on the Expression of Genes Related to the Insulin Pathway in Early Breast Cancer

Alessandra Gennari et al.

Summary: Insulin signaling plays a key role in breast cancer prognosis, with potential implications for preventive and treatment strategies.

BREAST CARE (2021)

Article Oncology

Infiltration of CD204-overexpressing Macrophages Contributes to the Progression of Stage II and III Colorectal Cancer

Yoichiro Tada et al.

Summary: Infiltration of CD204-positive macrophages is significantly associated with shorter overall and relapse-free survival in colorectal cancer patients, while M2-polarized macrophages promote proliferation and invasion of CRC cells.

ANTICANCER RESEARCH (2021)

Article Chemistry, Medicinal

Hydroxypyridinethione Inhibitors of Human Insulin-Degrading Enzyme

Rebecca N. Adamek et al.

Summary: IDE, a mononuclear Zn2+-dependent metalloenzyme, plays a crucial role in the degradation of insulin and various other peptide hormones. Research on IDE inhibitors is important for understanding its role in diseases such as diabetes and Alzheimer's. Several potential IDE inhibitors have been discovered, showing promise as pharmacological tools for future studies.

CHEMMEDCHEM (2021)

Review Biochemistry & Molecular Biology

Targeting Insulin-Degrading Enzyme in Insulin Clearance

Malcolm A. Leissring et al.

Summary: Hepatic insulin clearance and the activity of insulin-degrading enzyme might be involved in the pathogenesis of type 2 diabetes mellitus, and the development of IDE inhibitors as therapeutics for diabetic patients has garnered attention.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

Obesity, Type 2 Diabetes, and Cancer Risk

Tiffany Scully et al.

Summary: Obesity and type 2 diabetes are both linked to increased cancer risk, with metabolic abnormalities playing a key role in the relationship and progression of cancer. Multiple mechanisms, including insulin signaling, lipid and glucose metabolism, as well as changes in adipose tissue, are proposed to be involved in the association between obesity, diabetes, and cancer.

FRONTIERS IN ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

From virus to diabetes therapy: Characterization of a specific insulin-degrading enzyme inhibitor for diabetes treatment

Yuval Nash et al.

Summary: Inhibition of IDE with a designed VZV-derived peptide shows promise in ameliorating insulin-related defects in diabetes and improving the pro-inflammatory profile of CD4(+) T-cells towards insulin.

FASEB JOURNAL (2021)

Review Biochemistry & Molecular Biology

S-Nitrosylation in Tumor Microenvironment

Vandana Sharma et al.

Summary: S-nitrosylation is a selective and reversible post-translational modification of protein thiols by nitric oxide, playing key roles in propagating NO signals within cells, tissues, and tissue microenvironments. It can modulate protein conformation, activity, stability, and protein-protein interactions, and has been implicated in both tumor-suppressing and tumor-promoting effects, as well as being an essential regulator of the tumor microenvironment. Therapeutic potentials of modulating S-nitrosylation levels in tumors will also be discussed.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

Neuroendocrine Factors in Melanoma Pathogenesis

Cristian Scheau et al.

Summary: Melanoma is an aggressive and fatal malignant tumor, with early diagnosis being curable but advanced stages having high mortality rates. Studies have focused on neuroendocrine factors' role in melanoma development, but there are still unknown features to uncover. Investigating how neuroendocrine factors influence melanoma's clinical course may lead to new biomedical research areas and therapeutic approaches.

CANCERS (2021)

Article Biochemistry & Molecular Biology

Quantitative NMR Study of Insulin-Degrading Enzyme Using Amyloid-β and HIV-1 p6 Elucidates Its Chaperone Activity

Bhargavi Ramaraju et al.

Summary: The study compared the interactions of Aβ and p6 with IDE, finding that IDE can differentiate between non-amyloidogenic and amyloidogenic substrates by modulating intermolecular interactions. IDE forms different types of complexes with Aβ and p6, impacting the critical concentration needed for fibrillization.

BIOCHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer

Aldona Kasprzak

Summary: Colorectal cancer is a common aggressive carcinoma with poor prognosis, often associated with metabolic syndrome and high blood sugar levels. The role of IGF-1 in glucose metabolism in colorectal carcinogenesis and its potential link to the Warburg effect require further investigation. Current therapeutic strategies targeting impaired glucose metabolism in CRC are being explored to improve treatment outcomes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Revising Endosomal Trafficking under Insulin Receptor Activation

Maria J. Iraburu et al.

Summary: The endocytosis of ligand-bound receptors and their recycling to the plasma membrane are important for cell functions. The insulin receptor can be endocytosed by clathrin-dependent and independent mechanisms, and the sorting of the receptor at the early endosome determines the intensity and duration of insulin effects. Various proteins, including the Arf and Rab families of small GTPases, regulate the endocytic and endosomal pathways. This article argues for a specific role of the slow recycling route in INSR endocytosis and provides a review of the molecular mechanisms involved.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases

Luis Sousa et al.

Summary: IDE goes beyond its proteolytic role and has diverse functions, including molecular chaperone activity and regulation of protein homeostasis. Dysregulation of IDE may lead to increased protein aggregation, contributing to the pathogenesis of diseases such as diabetes and neurodegenerative diseases.

JOURNAL OF PATHOLOGY (2021)

Article Cell Biology

Insulin-Degrading Enzyme: Paradoxes and Possibilities

Malcolm A. Leissring

Summary: There are still many important unresolved questions in the field of IDE, such as how IDE interacts with extracellular substrates, its localization and functional roles within the cell, and how it avoids getting clogged and losing activity. The author provides personal insights and experimental strategies to address these challenges, aiming to advance the research on the physiology and pathophysiology of IDE with the development of new technologies and specific reagents.

CELLS (2021)

Article Cell Biology

Effects of Fasting and Feeding on Transcriptional and Posttranscriptional Regulation of Insulin-Degrading Enzyme in Mice

Carlos M. Gonzalez-Casimiro et al.

Summary: This study investigates the regulation of insulin-degrading enzyme (IDE) in the liver, skeletal muscle, and kidneys of mice under fasting and refeeding conditions, revealing a direct correlation between circulating lactate concentrations and IDE activity and protein levels. The study also suggests that IDE regulation in liver and muscle tissues is more complex than previously expected, with fasting/refeeding having little influence on renal IDE regulation.

CELLS (2021)

Review Oncology

Targeting Adipokines in Obesity-Related Tumors

Xi Pu et al.

Summary: Obesity is a global epidemic and closely related to the occurrence and development of various tumors, adipokines secreted by adipocytes and insulin/IGF play important roles in tumors.

FRONTIERS IN ONCOLOGY (2021)

Article Biochemical Research Methods

Drug Target Engagement Using Coupled Cellular Thermal Shift Assay-Acoustic Reverse-Phase Protein Array

Adrien Herledan et al.

SLAS DISCOVERY (2020)

Review Endocrinology & Metabolism

Rethinking the Relationship between Insulin and Cancer

R. Vigneri et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2020)

Review Biochemistry & Molecular Biology

CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands

Jan Korbecki et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

The Links between Parkinson's Disease and Cancer

Maria Ejma et al.

BIOMEDICINES (2020)

Review Pharmacology & Pharmacy

A Practical Review of Proteasome Pharmacology

Tiffany A. Thibaudeau et al.

PHARMACOLOGICAL REVIEWS (2019)

Review Neurosciences

Alzheimer's Disease and Cancer: When Two Monsters Cannot Be Together

Shohreh Majd et al.

FRONTIERS IN NEUROSCIENCE (2019)

Article Biochemistry & Molecular Biology

Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme

Juan Pablo Maianti et al.

NATURE CHEMICAL BIOLOGY (2019)

Review Physiology

Hepatic Insulin Clearance: Mechanism and Physiology

Sonia M. Najjar et al.

PHYSIOLOGY (2019)

Article Endocrinology & Metabolism

Pancreatic β-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and β-cell functional immaturity

Cristina M. Fernandez-Diaz et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2019)

Article Multidisciplinary Sciences

Amyloid β oligomers inhibit growth of human cancer cells

Bozena Pavliukeviciene et al.

PLOS ONE (2019)

Article Chemistry, Medicinal

Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening

Florence Leroux et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

SIRT4 regulates PTEN stability through IDE in response to cellular stresses

Minghui Liu et al.

FASEB JOURNAL (2019)

Review Medicine, General & Internal

Inflammation and Cancer

Nitin Singh et al.

ANNALS OF AFRICAN MEDICINE (2019)

Article Biochemistry & Molecular Biology

Molecular Determinants of Substrate Specificity in Human Insulin-Degrading Enzyme

Lazaros Stefanidis et al.

BIOCHEMISTRY (2018)

Article Biochemistry & Molecular Biology

The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S

Diego Sbardella et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

Review Biochemistry & Molecular Biology

Ubiquitination: Friend and foe in cancer

Mohammed A. Mansour

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

Review Cell Biology

The cell biology of systemic insulin function

Victoria L. Tokarz et al.

JOURNAL OF CELL BIOLOGY (2018)

Article Chemistry, Medicinal

Stabilized β-Hairpin Peptide Inhibits Insulin Degrading Enzyme

Dan Yang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Cell Biology

Regulation of proteasome assembly and activity in health and disease

Adrien Rousseau et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Insulin Receptor Isoforms in Cancer

Veronica Vella et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Biochemistry & Molecular Biology

Natriuretic Peptides: The Case of Prostate Cancer

Letizia Mezzasoma et al.

MOLECULES (2017)

Article Multidisciplinary Sciences

Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes

Eun Suk Song et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Interleukin-6 increases the expression and activity of insulin-degrading enzyme

Mirian A. Kurauti et al.

SCIENTIFIC REPORTS (2017)

Review Oncology

The proteasome and proteasome inhibitors in multiple myeloma

Sara Gandolfi et al.

CANCER AND METASTASIS REVIEWS (2017)

Review Biochemistry & Molecular Biology

Multiple functions of insulin-degrading enzyme: a metabolic crosslight?

Grazia R. Tundo et al.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2017)

Review Oncology

Targeting autophagy in cancer

Jean M. Mulcahy Levy et al.

NATURE REVIEWS CANCER (2017)

Article Medicine, Research & Experimental

Insulin supplementation attenuates cancer-induced cardiomyopathy and slows tumor disease progression

James T. Thackeray et al.

JCI INSIGHT (2017)

Review Medicine, General & Internal

Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer's disease?

Olga Pivovarova et al.

ANNALS OF MEDICINE (2016)

Review Oncology

Endoplasmic Reticulum Stress and the Hallmarks of Cancer

Hery Urra et al.

TRENDS IN CANCER (2016)

Article Chemistry, Multidisciplinary

The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin

G. Grasso et al.

CHEMICAL COMMUNICATIONS (2015)

Article Oncology

Regulation of nonsmall-cell lung cancer stem cell like cells by neurotransmitters and opioid peptides

Jheelam Banerjee et al.

INTERNATIONAL JOURNAL OF CANCER (2015)

Editorial Material Oncology

The Role of Multidrug Resistance Efflux Pumps in Cancer: Revisiting a JNCI Publication Exploring Expression of the MDR1 (P-glycoprotein) Gene

Michael M. Gottesman et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)

Article Multidisciplinary Sciences

Proteasome Activity Is Affected by Fluctuations in Insulin-Degrading Enzyme Distribution

Diego Sbardella et al.

PLOS ONE (2015)

Article Multidisciplinary Sciences

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

Rebecca Deprez-Poulain et al.

NATURE COMMUNICATIONS (2015)

Article Multidisciplinary Sciences

Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner

Sandeep K. Sharma et al.

SCIENTIFIC REPORTS (2015)

Editorial Material Oncology

The Role of Multidrug Resistance Efflux Pumps in Cancer: Revisiting a JNCI Publication Exploring Expression of the MDR1 (P-glycoprotein) Gene

Michael M. Gottesman et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)

Review Oncology

The insulin/IGF system in colorectal cancer development and resistance to therapy

Paolo Giovanni Vigneri et al.

FRONTIERS IN ONCOLOGY (2015)

Article Biochemistry & Molecular Biology

Novel Platinum(II) compounds modulate insulin-degrading enzyme activity and induce cell death in neuroblastoma cells

Grazia R. Tundo et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2015)

Review Oncology

The role of kinin receptors in cancer and therapeutic opportunities

Patricia L. N. da Costa et al.

CANCER LETTERS (2014)

Article Multidisciplinary Sciences

No Major Role for Insulin-Degrading Enzyme in Antigen Presentation by MHC Molecules

Slobodan Culina et al.

PLOS ONE (2014)

Article Medicine, Research & Experimental

Class A scavenger receptor activation inhibits endoplasmic reticulum stress-induced autophagy in macrophage

Hanpeng Huang et al.

JOURNAL OF BIOMEDICAL RESEARCH (2014)

Article Cardiac & Cardiovascular Systems

Insulin-degrading enzyme deficiency in bone marrow cells increases atherosclerosis in LDL receptor-deficient mice

Justin W. Caravaggio et al.

CARDIOVASCULAR PATHOLOGY (2013)

Review Oncology

IGF2 and cancer

Callum Livingstone

ENDOCRINE-RELATED CANCER (2013)

Article Biochemistry & Molecular Biology

Insulin-degrading Enzyme (IDE) A NOVEL HEAT SHOCK-LIKE PROTEIN

Grazia Raffaella Tundo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Multidisciplinary Sciences

Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

Lauren A. McCord et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Biotechnology & Applied Microbiology

The Role of Epidermal Growth Factor Receptor in Cancer Metastasis and Microenvironment

Takamitsu Sasaki et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Review Oncology

Protein S-nitrosylation and cancer

Zhaoqing Wang

CANCER LETTERS (2012)

Article Biochemistry & Molecular Biology

Anion Activation Site of Insulin-degrading Enzyme

Nicholas Noinaj et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides

Yun-Gon Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

Insulin-degrading Enzyme Modulates the Natriuretic Peptide-mediated Signaling Response

Luis A. Ralat et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Ubiquitin Is a Novel Substrate for Human Insulin-Degrading Enzyme

Luis A. Ralat et al.

JOURNAL OF MOLECULAR BIOLOGY (2011)

Article Multidisciplinary Sciences

Identification of the Allosteric Regulatory Site of Insulysin

Nicholas Noinaj et al.

PLOS ONE (2011)

Review Endocrinology & Metabolism

Intracellular insulin in human tumors: examples and implications

Razvan T. Radulescu

DIABETOLOGY & METABOLIC SYNDROME (2011)

Article Biochemistry & Molecular Biology

Retinoblastoma protein co-purifies with proteasomal insulin-degrading enzyme: Implications for cell proliferation control

Razvan T. Radulescu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Article Biochemistry & Molecular Biology

Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-α, and Amylin by Human Insulin-Degrading Enzyme

Qing Guo et al.

JOURNAL OF MOLECULAR BIOLOGY (2010)

Article Immunology

Production of an antigenic peptide by insulin-degrading enzyme

Nicolas Parmentier et al.

NATURE IMMUNOLOGY (2010)

Article Multidisciplinary Sciences

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin

Malcolm A. Leissring et al.

PLOS ONE (2010)

Article Endocrinology & Metabolism

Glucose inhibits the insulin-induced activation of the insulin-degrading enzyme in HepG2 cells

O. Pivovarova et al.

DIABETOLOGIA (2009)

Review Oncology

Diabetes and cancer

Paolo Vigneri et al.

ENDOCRINE-RELATED CANCER (2009)

Article Biochemistry & Molecular Biology

Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme

Ying-Hao Chou et al.

FASEB JOURNAL (2009)

Article Biochemistry & Molecular Biology

Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

Marika Manolopoulou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Somatostatin: A Novel Substrate and a Modulator of Insulin-Degrading Enzyme Activity

Chiara Ciaccio et al.

JOURNAL OF MOLECULAR BIOLOGY (2009)

Letter Oncology

Complex formation between metabolic enzymes in tumor cells: Unfolding the MDR1-IDE paradigm

Razvan T. Radulescu et al.

MOLECULAR CANCER THERAPEUTICS (2009)

Article Neurosciences

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway

Ji Zhao et al.

MOLECULAR NEURODEGENERATION (2009)

Article Biochemistry & Molecular Biology

How the binding and degrading capabilities of insulin degrading enzyme are-affected by ubiquitin

Giuseppe Grasso et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2008)

Review Biochemistry & Molecular Biology

Amyloid β-degrading cryptidases:: insulin degrading enzyme, presequence peptidase, and neprilysin

E. Malito et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

Article Cell Biology

Antitumor effects of somatostatin

Stephane Pyronnet et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2008)

Review Oncology

Insulin and insulin-like growth factor signalling in neoplasia

Michael Pollak

NATURE REVIEWS CANCER (2008)

Article Biochemistry & Molecular Biology

Regulation of protein degradation by insulin-degrading enzyme: Analysis by small interfering RNA-mediated gene silencing

Janet Fawcett et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)

Article Oncology

IGF1R signalling and its inhibition

J. Riedemann et al.

ENDOCRINE-RELATED CANCER (2006)

Article Biochemistry & Molecular Biology

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

MA Leissring et al.

BIOCHEMICAL JOURNAL (2004)

Article Cell Biology

Non-covalent interaction of ubiquitin with insulin-degrading enzyme

T Saric et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2003)

Article Multidisciplinary Sciences

Amyloid-β peptide levels in brain are inversely correlated with insulysin activity levels in vivo

BC Miller et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Medicine, General & Internal

Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults

EE Calle et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

Article Multidisciplinary Sciences

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

W Farris et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Degradation of amylin by insulin-degrading enzyme

RG Bennett et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)