Journal
CELLS
Volume 11, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/cells11071192
Keywords
RBM8A; MAGOH; MLN51; neurodevelopment; NMD; mRNA
Categories
Funding
- National Institute of Mental Health of the National Institutes of Health [R21MH108983, R01MH122556]
- PSU IEE SEED
Ask authors/readers for more resources
The exon junction complex (EJC) is a complex that plays an important regulatory role in the central nervous system (CNS) and other tissues. It consists of several core proteins and auxiliary factors, and regulates multiple levels of gene expression. Dysfunction of the EJC is implicated in various developmental and neurological diseases.
The exon junction complex (EJC) becomes an increasingly important regulator of early gene expression in the central nervous system (CNS) and other tissues. The EJC is comprised of three core proteins: RNA-binding motif 8A (RBM8A), Mago homolog (MAGOH), eukaryotic initiation factor 4A3 (EIF4A3), and a peripheral EJC factor, metastatic lymph node 51 (MLN51), together with various auxiliary factors. The EJC is assembled specifically at exon-exon junctions on mRNAs, hence the name of the complex. The EJC regulates multiple levels of gene expression, from splicing to translation and mRNA degradation. The functional roles of the EJC have been established as crucial to the normal progress of embryonic and neurological development, with wide ranging implications on molecular, cellular, and organism level function. Dysfunction of the EJC has been implicated in multiple developmental and neurological diseases. In this review, we discuss recent progress on the EJC's physiological roles.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available