Journal
CELLS
Volume 11, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/cells11101684
Keywords
TUCR; ultraconserved; cancer; long non-coding RNA
Categories
Funding
- NIH [UO1 CA220841]
- NCI Cancer Center Support Grant [5P30CA044579]
- NINDS [1R21NS122136-01]
- Schiff Foundation
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Transcribed ultraconserved regions (TUCRs) are putative lncRNA molecules transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. Despite the poor conservation of lncRNAs, the study of TUCRs in diseases, including cancer, remains understudied. This review summarizes the current literature on TUCRs in cancer, including their deregulated expression, functional roles, mechanisms of action, and clinical perspectives.
Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we summarize the current literature on TUCRs in cancer with respect to expression deregulation, functional roles, mechanisms of action, and clinical perspectives.
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