Cellular Senescence in Aging Lungs and Diseases

Cellular senescence represents a state of irreversible cell cycle arrest occurring naturally or in response to exogenous stressors. Following the initial arrest, progressive phenotypic changes define conditions of cellular senescence. Understanding molecular mechanisms that drive senescence can help to recognize the importance of such pathways in lung health and disease. There is increasing interest in the role of cellular senescence in conditions such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) in the context of understanding pathophysiology and identification of novel therapies. Herein, we discuss the current knowledge of molecular mechanisms and mitochondrial dysfunction regulating different aspects of cellular senescence-related to chronic lung diseases to develop rational strategies for modulating the senescent cell phenotype in the lung for therapeutic benefit.

Automated summary

Cellular senescence is an irreversible cell cycle arrest that occurs naturally or in response to external stressors. Understanding the molecular mechanisms behind senescence is important in the context of lung health and disease. There is increasing interest in the role of senescence in chronic lung diseases and its potential for identifying novel therapies.