Journal
CELLS
Volume 11, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/cells11101665
Keywords
heat shock protein 27(HSP27); squamous cell carcinoma (SCC); clinicopathological; prognostic
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Funding
- National Innovation Research Group Cultivation Program [xyd2021C001]
- Key Research and Development Project of the Xinjiang Uygur Autonomous Region [2020B03003-1]
- special funds for the development of local science and technology from the central government [ZYYD2022B06]
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This review critically examines the role of heat shock protein 27 in squamous cell carcinoma from clinicopathological and prognostic perspectives, excluding studies on adenocarcinoma to understand its enigmatic role in tumorigenesis at different stages.
Initially discovered to be induced by heat shock, heat shock protein 27 (HSP27, also called HSPB1), a member of the small HSP family, can help cells better withstand or avoid heat shock damage. After years of studies, HSP27 was gradually found to be extensively engaged in various physiological or pathophysiological activities. Herein, revisiting the previously published data concerning HSP27, we conducted a critical review of the literature regarding its role in squamous cell carcinoma (SCC) from the perspective of clinicopathological and prognostic significance, excluding studies conducted on adenocarcinoma, which is very different from SCC, to understand the enigmatic role of HSP27 in the tumorigenesis of SCC, including normal mucosa, dysplasia, intraepithelial neoplasm, carcinoma in situ and invasive SCC.
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