Journal
CELLS
Volume 11, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/cells11111794
Keywords
MACS; sperm; sperm selection; IUI; sperm DNA fragmentation
Categories
Funding
- Ministry of Science, Innovation and Universities, Government of Spain [FPU19/03393, FPU20/03621]
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This study analyzed the clinical outcomes of magnetic-activated cell sorting (MACS) on donor intrauterine insemination (D-IUI) cycles. The results showed no significant differences in gestation, live birth, or miscarriage rates between the MACS group and the control group. Further studies with a larger sample size are needed to evaluate the application of MACS in fertility clinics.
Clinical outcome in assisted reproduction techniques (ARTs) is mainly influenced by the quality of gametes used. It is known that a high percentage of sperm DNA fragmentation (DNAf) decreases the success of ART clinical results. Therefore, techniques such as magnetic-activated cell sorting (MACS) help to improve results in cases of patients with a high percentage of DNAf. Cryopreservation of sperm in donor intrauterine insemination (D-IUI) treatments increases sperm DNAf, so patients using these sperm samples can benefit from using this technique. This prospective randomized national multicenter study analyzed clinical outcomes of 181 D-IUI treatments. MACS was performed after density gradient centrifugation (DGC) in 90 thawed semen donor samples (MACSG), whereas only DGC was performed in 91 thawed semen donor samples (CG). To our knowledge, this is the first study analyzing the effect of MACS on D-IUI cycles. Our results show no significant differences in gestation, live birth, or miscarriage rates between the two groups. We believe that further studies with a larger sample size are needed to evaluate the application of MACS in combination with standard IUI donor sperm preparations in fertility clinics.
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