Journal
CELLS
Volume 11, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/cells11050759
Keywords
lung; inflammation; remodelling; allergic asthma; therapy; peptide Ac2-26
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The study found that the peptide Ac2-26 and its derivative AnxA1 regulate the inflammatory response in allergic asthma triggered by house dust mite extract. The peptide Ac2-26 decreased eosinophil infiltration, fibrosis, and mucus exacerbation caused by the allergen challenge and also inhibited airway hyperreactivity and mediator production. These findings suggest that Ac2-26 or similar compounds could be potential therapeutic candidates for allergic asthma treatment.
Annexin-A1 (AnxA1) and its N-terminal derived peptide Ac2-26 regulate the inflammatory response in several experimental models of disorders. This study evaluated the effect of endogenous AnxA1 and its N-terminal peptide Acetyl 2-26 (Ac2-26) on allergic asthma triggered by house dust mite (HDM) extract in mice. ANXA1(-/-) and wildtype (WT) mice were exposed to intranasal instillation of HDM every other day for 3 weeks, with analyses performed 24 h following the last exposure. Intranasal administration of peptide Ac2-26 was performed 1 h before HDM, beginning 1 week after the initial antigen application. ANXA1(-/-) mice stimulated with HDM showed marked exacerbations of airway hyperreactivity (AHR), eosinophil accumulation, subepithelial fibrosis, and mucus hypersecretion, all parameters correlating with overexpression of cytokines (IL-4, IL-13, TNF-alpha, and TGF-beta) and chemokines (CCL11/eotaxin-1 and CCL2/MCP-1). Intranasal treatment with peptide Ac2-26 decreased eosinophil infiltration, peribronchiolar fibrosis, and mucus exacerbation caused by the allergen challenge. Ac2-26 also inhibited AHR and mediator production. Collectively, our findings show that the AnxA1-derived peptide Ac2-26 protects against several pathological changes associated with HDM allergic reaction, suggesting that this peptide or related AnxA1-mimetic Ac2-26 may represent promising therapeutic candidates for the treatment of allergic asthma.
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