4.6 Review

YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy

Journal

CELLS
Volume 11, Issue 7, Pages -

Publisher

MDPI
DOI: 10.3390/cells11071217

Keywords

YB-1; transcription factor; cancer; RNA binding protein; therapeutic target

Categories

Funding

  1. National Key R&D Program of China [2020YFA0112300, 2020YFA0803200]
  2. National Natural Science Foundation of China [U2102203, 82173014, 81830087, 81872414]
  3. CAS Light of West China program
  4. Yunnan Fundamental Research Projects [202001AW070018, 202101AS070050, 2019FB112]
  5. Reserve talents for Yunnan Province of Medical Science [H-2018078]

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Y box binding protein 1 (YB-1) is a versatile protein with important roles in gene transcription, RNA splicing, DNA damage repair, cell cycle progression, and immunity. Accumulating evidence suggests that YB-1 promotes tumor progression in various types of cancers and may serve as a potential therapeutic target.
Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD) that also belongs to the family of DNA- and RNA-binding proteins. YB-1 is present in both the nucleus and cytoplasm and plays versatile roles in gene transcription, RNA splicing, DNA damage repair, cell cycle progression, and immunity. Cumulative evidence suggests that YB-1 promotes the progression of multiple tumor types and serves as a potential tumor biomarker and therapeutic target. This review comprehensively summarizes the emerging functions, mechanisms, and regulation of YB-1 in cancers, and further discusses targeted strategies.

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