Related references
Note: Only part of the references are listed.Insights into the critical role of the PXR in preventing carcinogenesis and chemotherapeutic drug resistance
Xiaxia Niu et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)
Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding
Melanie Schneider et al.
JOURNAL OF MEDICINAL CHEMISTRY (2022)
Properties of FDA-approved small molecule protein kinase inhibitors: A 2022 update
Robert Roskoski
PHARMACOLOGICAL RESEARCH (2022)
Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70
Yongtao Li et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Nelfinavir and Its Active Metabolite M8 Are Partial Agonists and Competitive Antagonists of the Human Pregnane X Receptor
Oliver Burk et al.
MOLECULAR PHARMACOLOGY (2021)
Designing Out PXR Activity on Drug Discovery Projects: A Review of Structure-Based Methods, Empirical and Computational Approaches
Adrian Hall et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Trends in kinase drug discovery: targets, indications and inhibitor design
Misty M. Attwood et al.
NATURE REVIEWS DRUG DISCOVERY (2021)
PXR: a center of transcriptional regulation in cancer
Yaqi Xing et al.
ACTA PHARMACEUTICA SINICA B (2020)
Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer
Sergio C. Chai et al.
MEDICINAL RESEARCH REVIEWS (2020)
Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three-Dimensional Spheroid Cultures of Primary Human Hepatocytes
Delilah F. G. Hendriks et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2020)
The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor
Nicolas Creusot et al.
CELLS (2020)
OPLS3e: Extending Force Field Coverage for Drug-Like Small Molecules
Katarina Roos et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2019)
Clinical applications of small molecule inhibitors of Pregnane X receptor
Jeff L. Staudinger
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2019)
Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles
Oliver Burk et al.
ARCHIVES OF TOXICOLOGY (2018)
Pregnane X receptor mediates sorafenib resistance in advanced hepatocellular carcinoma
Fan Feng et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2018)
Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro
Guncha Taneja et al.
DRUG METABOLISM AND DISPOSITION (2018)
A comprehensive review of protein kinase inhibitors for cancer therapy
Radhamani Kannaiyan et al.
EXPERT REVIEW OF ANTICANCER THERAPY (2018)
Binding Affinity via Docking: Fact and Fiction
Tatu Pantsar et al.
MOLECULES (2018)
Commentary: Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!
Marius Pollet et al.
FRONTIERS IN PHARMACOLOGY (2018)
Non-kinase targets of protein kinase inhibitors
Lenka Munoz
NATURE REVIEWS DRUG DISCOVERY (2017)
SPA70 is a potent antagonist of human pregnane X receptor
Wenwei Lin et al.
NATURE COMMUNICATIONS (2017)
Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor
Judith Jeske et al.
ARCHIVES OF TOXICOLOGY (2017)
The drug-drug interaction of sorafenib mediated by P-glycoprotein and CYP3A4
Xianming Wang et al.
XENOBIOTICA (2016)
Inhibition of pregnane X receptor pathway contributes to the cell growth inhibition and apoptosis of anticancer agents in ovarian cancer cells
Hisashi Masuyama et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2016)
Carboxymefloquine, the Major Metabolite of the Antimalarial Drug Mefloquine, Induces Drug-Metabolizing Enzyme and Transporter Expression by Activation of Pregnane X Receptor
Rita Piedade et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms
Andreas Bitter et al.
ARCHIVES OF TOXICOLOGY (2015)
U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells
Tomas Smutny et al.
ARCHIVES OF TOXICOLOGY (2014)
3D structures and ligand specificities of nuclear xenobiotic receptors CAR, PXR and VDR
Baojian Wu et al.
DRUG DISCOVERY TODAY (2013)
PXR-mediated P-glycoprotein induction by small molecule tyrosine kinase inhibitors
S. Harmsen et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2013)
Jaguar: A high-performance quantum chemistry software program with strengths in life and materials sciences
Art D. Bochevarov et al.
INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY (2013)
Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRα
Bret D. Wallace et al.
JOURNAL OF MOLECULAR BIOLOGY (2013)
Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoforms
O. Burk et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor
E. Hoffart et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Role of CAR and PXR in xenobiotic sensing and metabolism
Yue-Ming Wang et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2012)
Targeting the Hinge Glycine Flip and the Activation Loop: Novel Approach to Potent p38α Inhibitors
Kathrin E. Martz et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Steroid receptor coactivators 1, 2, and 3: Critical regulators of nuclear receptor activity and steroid receptor modulator (SRM)-based cancer therapy
Amber B. Johnson et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)
Evolutionary History and Functional Characterization of the Amphibian Xenosensor CAR
Marianne Mathaes et al.
MOLECULAR ENDOCRINOLOGY (2012)
Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells
Sebastien Antherieu et al.
DRUG METABOLISM AND DISPOSITION (2010)
Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution
Jeremy R. Greenwood et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2010)
Molecular Switch in the Glucocorticoid Receptor: Active and Passive Antagonist Conformations
Guillaume A. Schoch et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Camptothecin Attenuates Cytochrome P450 3A4 Induction by Blocking the Activation of Human Pregnane X Receptor
Yakun Chen et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
Comparison of ATP-Binding Cassette Transporter Interactions with the Tyrosine Kinase Inhibitors Imatinib, Nilotinib, and Dasatinib
Marius Dohse et al.
DRUG METABOLISM AND DISPOSITION (2010)
A Phosphomimetic Mutation at Threonine-57 Abolishes Transactivation Activity and Alters Nuclear Localization Pattern of Human Pregnane X Receptor
Satyanarayana R. Pondugula et al.
DRUG METABOLISM AND DISPOSITION (2009)
Cyclic AMP-dependent Protein Kinase Signaling Modulates Pregnane x Receptor Activity in a Species-specific Manner
Kristin Lichti-Kaiser et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Cyclin-dependent Kinase 2 Negatively Regulates Human Pregnane X Receptor-mediated CYP3A4 Gene Expression in HepG2 Liver Carcinoma Cells
Wenwei Lin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The phytoestrogen Coumestrol is a naturally occurring antagonist of the human pregnane x receptor
Hongwei Wang et al.
MOLECULAR ENDOCRINOLOGY (2008)
Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole
H. Huang et al.
ONCOGENE (2007)
Extra precision glide: Docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes
Richard A. Friesner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies
R Farid et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Novel procedure for modeling ligand/receptor induced fit effects
W Sherman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Use of an induced fit receptor structure in virtual screening
W Sherman et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2006)
Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells
C Aninat et al.
DRUG METABOLISM AND DISPOSITION (2006)
Antimalarial artemisinin drugs induce cytochrome p450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor
O Burk et al.
MOLECULAR PHARMACOLOGY (2005)
Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C
XS Ding et al.
BIOCHEMICAL PHARMACOLOGY (2005)
Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
RA Friesner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Glide: A new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening
TA Halgren et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays
ZR Zhu et al.
JOURNAL OF BIOMOLECULAR SCREENING (2004)
Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine
O Burk et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
A Geick et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Share Paper
