4.6 Article

GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Discovery of Bile Acid Derivatives as Potent ACE2 Activators by Virtual Screening and Essential Dynamics

Bianca Fiorillo et al.

Summary: ACE2 plays a crucial role in vessel contraction, inflammation, and oxidative stress reduction, and serves as the first receptor for the SARS-CoV-2 virus, facilitating its entry into host cells. Certain ursodeoxycholic acid derivatives have been identified as ACE2 activators, showing comparable activity to the most potent known activator, DIZE, in in vitro pharmacological assays. These findings provide valuable insights for the development of therapeutic compounds against SARS-CoV-2 infection and other ACE2-related diseases.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2022)

Review Cell Biology

Mechanisms of SARS-CoV-2 entry into cells

Cody B. Jackson et al.

Summary: The entry of SARS-CoV-2 into host cells is facilitated by the interaction between the viral spike protein and ACE2, leading to virus-cell membrane fusion, which has been extensively studied at the structural and cellular levels worldwide. This understanding has paved the way for the development of effective vaccines in response to the COVID-19 pandemic, caused by the infection with SARS-CoV-2.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Review Chemistry, Medicinal

Designing therapeutic strategies to combat severe acute respiratory syndrome coronavirus-2 disease:COVID-19

Suman Rohilla

Summary: COVID-19, caused by SARS-CoV-2, has become a major global health crisis with no specific vaccine or antiviral drugs available. The rapid spread of the virus highlights the urgent need for effective therapeutic strategies. Understanding the disease pathology is crucial for developing targeted treatments.

DRUG DEVELOPMENT RESEARCH (2021)

Article Gastroenterology & Hepatology

Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2-related Disease

Mayte Suarez-Farinas et al.

Summary: The study shows that the COVID-19 virus has the ability to invade the intestines, and medications used by IBD patients do not significantly affect receptor expression in uninflamed intestines. There are shared molecular networks between COVID-19 infection and IBD.

GASTROENTEROLOGY (2021)

Review Multidisciplinary Sciences

Recent advance of ACE2 and microbiota dysfunction in COVID-19 pathogenesis

Zhidan Yu et al.

Summary: The SARS-CoV-2 virus responsible for COVID-19 has become a major global health threat, leading to not only respiratory symptoms but also gastrointestinal issues in some patients, possibly linked to ACE2 receptors and alterations in gut microbiota.

HELIYON (2021)

Review Gastroenterology & Hepatology

Bile Acid Signaling in Inflammatory Bowel Diseases

Stefano Fiorucci et al.

Summary: Bile acids generated at the host liver and through microbial metabolism play a crucial role in mediating communication between the intestinal microbiota and host immune system. The expression and function of bile acid-activated receptors are dependent on the structure of the intestinal microbiota, with implications for maintaining a tolerogenic phenotype in the intestine.

DIGESTIVE DISEASES AND SCIENCES (2021)

Article Gastroenterology & Hepatology

Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease

Alka A. Potdar et al.

Summary: The study identified differences in intestinal ACE2 expression levels in patients with Crohn's disease and ulcerative colitis, associated with inflammation and disease severity. Treatment with anti-cytokine therapy restored ACE2 expression, potentially impacting outcomes of severe acute respiratory syndrome coronavirus 2 infection.

GASTROENTEROLOGY (2021)

Article Immunology

Preliminary Evidence for IL-10-Induced ACE2 mRNA Expression in Lung-Derived and Endothelial Cells: Implications for SARS-Cov-2 ARDS Pathogenesis

Adriana Albini et al.

Summary: The research suggests that IL-10 may inhibit inflammation by increasing the expression of ACE2. Further studies are needed to confirm this mechanism, but IL-10 may have potential clinical relevance in COVID-19-related diseases by enhancing ACE2 levels.

FRONTIERS IN IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

Bile acids and their receptors in metabolic disorders

Stefano Fiorucci et al.

Summary: Bile acids play a crucial role in regulating metabolic processes by integrating their signaling with other receptors in a time-ordered manner synchronized by circadian rhythm. The last decade has seen challenges in developing systemic FXR agonists, with the emergence of intestinal-restricted and dual FXR/GPBAR1 agonists as potential alternatives.

PROGRESS IN LIPID RESEARCH (2021)

Article Pharmacology & Pharmacy

Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction

Michele Biagioli et al.

Summary: The study found that pelargonidin can reverse intestinal inflammation by activating the Aryl hydrocarbon Receptor, reducing ACE2 induction. This has potential implications for combating SARS-CoV-2.

BIOCHEMICAL PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Dynamic chromatin association of IκBα is regulated by acetylation and cleavage of histone H4

Laura Marruecos et al.

Summary: I kappa Bs act as cytoplasmic inhibitors of NF-kB transcription factors. Phosphorylated and SUMOylated I kappa B alpha binds to histones H2A and H4, influencing chromatin association and transcriptional regulation in skin and intestine stem cells and progenitor cells. Dynamic binding of I kappa B alpha to chromatin is necessary for intestinal cell differentiation, providing insight into the restricted nuclear distribution of p-I kappa B alpha in specific stem cell compartments.

EMBO REPORTS (2021)

Article Multidisciplinary Sciences

Increased colonic expression of ACE2 associates with poor prognosis in Crohn's disease

Takahiko Toyonaga et al.

Summary: The study found that colonic ACE2 expression is elevated in Crohn's disease patients, which may lead to a higher risk of surgery. CD patients with high ACE2 expression are more likely to undergo surgery within 5 years, with high ACE2 levels being an independent risk factor for surgery.

SCIENTIFIC REPORTS (2021)

Review Cell Biology

Bile Acids Activated Receptors in Inflammatory Bowel Disease

Michele Biagioli et al.

Summary: Bile acids have evolved from being solely involved in nutrient absorption to acting as signaling molecules that activate various immune cells, mediating chemical communication between the intestinal microbiota and the host. Changes in intestinal microbiota can lead to dysbiosis, altering the composition of the bile acid pool and promoting immune system activation and chronic inflammation.

CELLS (2021)

Article Chemistry, Medicinal

GPBAR1 Activation by C6-Substituted Hyodeoxycholane Analogues Protect against Colitis

Simona De Marino et al.

ACS MEDICINAL CHEMISTRY LETTERS (2020)

Article Biochemistry & Molecular Biology

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells

Joep Beumer et al.

Article Immunology

Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19

Guoping Li et al.

JOURNAL OF AUTOIMMUNITY (2020)

Article Pharmacology & Pharmacy

Bile acid-activated receptors and the regulation of macrophages function in metabolic disorders

Stefano Fiorucci et al.

CURRENT OPINION IN PHARMACOLOGY (2020)

Article Multidisciplinary Sciences

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor

Jinsung Yang et al.

NATURE COMMUNICATIONS (2020)

Review Medicine, Research & Experimental

ACE2 and gut amino acid transport

Simone M. R. Camargo et al.

CLINICAL SCIENCE (2020)

Article Multidisciplinary Sciences

Colonic epithelial cell diversity in health and inflammatory bowel disease

Kaushal Parikh et al.

NATURE (2019)

Article Multidisciplinary Sciences

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

Jason Lloyd-Price et al.

NATURE (2019)

Review Endocrinology & Metabolism

Glucagon-like peptide 1 (GLP-1)

T. D. Mueller et al.

MOLECULAR METABOLISM (2019)

Article Gastroenterology & Hepatology

GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated Hepatitis

Michele Biagioli et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2019)

Review Immunology

Bile Acids Activated Receptors Regulate innate immunity

Stefano Fiorucci et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Immunology

Causal effects of the microbiota on immune-mediated diseases

June L. Round et al.

SCIENCE IMMUNOLOGY (2018)

Article Biochemical Research Methods

Chemically induced mouse models of acute and chronic intestinal inflammation

Stefan Wirtz et al.

NATURE PROTOCOLS (2017)

Article Multidisciplinary Sciences

Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis

Maitham A. Khajah et al.

PLOS ONE (2016)

Review Biochemistry & Molecular Biology

Bile Acid-Activated Receptors, Intestinal Microbiota, and the Treatment of Metabolic Disorders

Stefano Fiorucci et al.

TRENDS IN MOLECULAR MEDICINE (2015)

Article Gastroenterology & Hepatology

Defective intestinal amino acid absorption in Ace2 null mice

Dustin Singer et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2012)

Article Multidisciplinary Sciences

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

Tatsuo Hashimoto et al.

NATURE (2012)

Article Gastroenterology & Hepatology

Tissue-Specific Amino Acid Transporter Partners ACE2 and Collectrin Differentially Interact With Hartnup Mutations

Simone M. R. Camargo et al.

GASTROENTEROLOGY (2009)

Article Endocrinology & Metabolism

Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice

Takaharu Maruyama et al.

JOURNAL OF ENDOCRINOLOGY (2006)

Article Biochemical Research Methods

High resolution colonoscopy in live mice

C. Becker et al.

NATURE PROTOCOLS (2006)

Article Biochemistry & Molecular Biology

Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1

S Katsuma et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Biochemistry & Molecular Biology

A G protein-coupled receptor responsive to bile acids

Y Kawamata et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Identification of membrane-type receptor for bile acids (M-BAR)

T Maruyama et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)