4.6 Review

LINCing Senescence and Nuclear Envelope Changes

Related references

Note: Only part of the references are listed.
Review Cell Biology

Epigenetic Regulation of Cellular Senescence

Jack Crouch et al.

Summary: Senescence is a complex cellular stress response that leads to loss of proliferative capacity and changes in secretory pattern. Transcriptional regulation of multiple genes and epigenetic alterations to DNA and chromatin play crucial roles in the induction and maintenance of senescence. This review highlights the changes in chromatin, DNA methylation, histone alterations, and the specific epigenetic regulation of the senescence-associated secretory phenotype (SASP).

CELLS (2022)

Review Engineering, Biomedical

Nuclear lamins: Structure and function in mechanobiology

Amir Vahabikashi et al.

Summary: Nuclear lamins are versatile proteins involved in chromatin organization, gene regulation, nuclear shape, cytoskeleton organization, and cell motility. Mutations in lamins contribute to various human diseases.

APL BIOENGINEERING (2022)

Review Cell Biology

Molecular models of LINC complex assembly at the nuclear envelope

Zeinab Jahed et al.

Summary: Large protein complexes called LINC complexes assemble at the nuclear envelope to transmit mechanical signals between the cytoskeleton and nucleoskeleton. These complexes are formed by the interaction of SUN and KASH domain proteins and can withstand and transfer forces across the nuclear envelope. Recent studies have shed light on the mechanisms of SUN-KASH interactions, their higher-order assembly, and the molecular mechanisms of force transfer across these complexes.

JOURNAL OF CELL SCIENCE (2021)

Article Biochemistry & Molecular Biology

Nesprin-1 impact on tumorigenic cell phenotypes

Ilknur Sur-Erdem et al.

MOLECULAR BIOLOGY REPORTS (2020)

Review Oncology

Telomeres and Telomere Length: A General Overview

Nalini Srinivas et al.

CANCERS (2020)

Review Oncology

Targeting the Wnt/β-catenin signaling pathway in cancer

Ya Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Review Genetics & Heredity

DNA-PKcs: A Multi-Faceted Player in DNA Damage Response

Xiaoqiao Yue et al.

FRONTIERS IN GENETICS (2020)

Article Cell Biology

The impact of oxidative DNA damage and stress on telomere homeostasis

Ryan P. Barnes et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2019)

Article Engineering, Biomedical

The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease

Melanie Maurer et al.

Annual Review of Biomedical Engineering (2019)

Review Cell Biology

Mitochondrial Homeostasis and Cellular Senescence

Panagiotis V. S. Vasileiou et al.

CELLS (2019)

Article Medicine, Research & Experimental

Cyclic mechanical tension reinforces DNA damage and activates the p53-p21-Rb pathway to induce premature senescence of nucleus pulposus cells

Chencheng Feng et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)

Article Endocrinology & Metabolism

Diminished Canonical β-Catenin Signaling During Osteoblast Differentiation Contributes to Osteopenia in Progeria

Ji Young Choi et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2018)

Review Cell Biology

Hallmarks of Cellular Senescence

Alejandra Hernandez-Segura et al.

TRENDS IN CELL BIOLOGY (2018)

Review Physiology

Nesprins and Lamins in Health and Diseases of Cardiac and Skeletal Muscles

Alexandre Janin et al.

FRONTIERS IN PHYSIOLOGY (2018)

Article Biochemistry & Molecular Biology

Chemical screening identifies ATM as a target for alleviating senescence

Hyun Tae Kang et al.

NATURE CHEMICAL BIOLOGY (2017)

Review Cell Biology

Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

Nard Kubben et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Review Cell Biology

Lamin in inflammation and aging

Joseph R. Tran et al.

CURRENT OPINION IN CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageing

D. T. Warren et al.

CELL DEATH AND DIFFERENTIATION (2015)

Article Biochemistry & Molecular Biology

Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid

Ana Gutierrez-Fernandez et al.

EMBO JOURNAL (2015)

Review Dermatology

Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin

Marco Demaria et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

Article Biotechnology & Applied Microbiology

Modelling the onset of senescence at the G1/S cell cycle checkpoint

Jose C. M. Mombach et al.

BMC GENOMICS (2014)

Article Biochemistry & Molecular Biology

Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation

M. Ogrunc et al.

CELL DEATH AND DIFFERENTIATION (2014)

Article Cell Biology

A role for nuclear envelope-bridging complexes in homology-directed repair

Rebecca K. Swartz et al.

MOLECULAR BIOLOGY OF THE CELL (2014)

Review Multidisciplinary Sciences

The role of senescent cells in ageing

Jan M. van Deursen

NATURE (2014)

Review Cell Biology

Nesprins in health and disease

Sarah Cartwright et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2014)

Article Cell Biology

Nesprin-1 role in DNA damage response

Ilknur Sur et al.

NUCLEUS-AUSTIN (2014)

Review Physiology

Aging, Cellular Senescence, and Cancer

Judith Campisi

ANNUAL REVIEW OF PHYSIOLOGY, VOL 75 (2013)

Article Biochemistry & Molecular Biology

Programmed Cell Senescence during Mammalian Embryonic Development

Daniel Munoz-Espin et al.

Article Biochemistry & Molecular Biology

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

Mekayla Storer et al.

Article Biochemistry & Molecular Biology

ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence

F. Fausti et al.

CELL DEATH AND DIFFERENTIATION (2013)

Review Biochemistry & Molecular Biology

The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin

Andrea Rothballer et al.

CHROMOSOMA (2013)

Review Biochemistry & Molecular Biology

Nuclear Mechanics and Mechanotransduction in Health and Disease

Philipp Isermann et al.

CURRENT BIOLOGY (2013)

Article Cell Biology

Lamin B1 fluctuations have differential effects on cellular proliferation and senescence

Oliver Dreesen et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Cell Biology

A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton

Henning F. Horn et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Cell Biology

Lysosome-mediated processing of chromatin in senescence

Andre Ivanov et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

Anil Rana et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion

Jorge de la Rosa et al.

NATURE COMMUNICATIONS (2013)

Article Cell Biology

The contrasting roles of lamin B1 in cellular aging and human disease

Oliver Dreesen et al.

NUCLEUS-AUSTIN (2013)

Review Pharmacology & Pharmacy

Small molecules, inhibitors of DNA-PK, targeting DNA repair, and beyond

David Davidson et al.

FRONTIERS IN PHARMACOLOGY (2013)

Article Biochemistry & Molecular Biology

Nesprin interchain associations control nuclear size

Wenshu Lu et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

Article Biochemistry & Molecular Biology

Inner Nuclear Envelope Proteins SUN1 and SUN2 Play a Prominent Role in the DNA Damage Response

Kai Lei et al.

CURRENT BIOLOGY (2012)

Article Gastroenterology & Hepatology

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

Xiaoni Kong et al.

HEPATOLOGY (2012)

Article Cell Biology

Lamin B1 loss is a senescence-associated biomarker

Adam Freund et al.

MOLECULAR BIOLOGY OF THE CELL (2012)

Article Cell Biology

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

Marzia Fumagalli et al.

NATURE CELL BIOLOGY (2012)

Article Multidisciplinary Sciences

Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling

Sumati Rajagopalan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

Nesprin-3: a versatile connector between the nucleus and the cytoskeleton

Mirjam Ketema et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2011)

Article Cell Biology

The role of nuclear lamin B1 in cell proliferation and senescence

Takeshi Shimi et al.

GENES & DEVELOPMENT (2011)

Article Biochemistry & Molecular Biology

KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development

Juehua Yu et al.

HUMAN MOLECULAR GENETICS (2011)

Article Cell Biology

Nesprin-3 augments peripheral nuclear localization of intermediate filaments in zebrafish

Ruben Postel et al.

JOURNAL OF CELL SCIENCE (2011)

Article Cell Biology

Cellular senescence controls fibrosis in wound healing

Joon-Il Jun et al.

AGING-US (2010)

Review Pathology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

Jean -Philippe Coppe et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

Article Hematology

Cardiovascular Pathology in Hutchinson-Gilford Progeria: Correlation With the Vascular Pathology of Aging

Michelle Olive et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Matrix metalloproteinases: Evolution, gene regulation and functional analysis in mouse models

Miriam Fanjul-Fernandez et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2010)

Review Biochemistry & Molecular Biology

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

Kai Kessenbrock et al.

Article Biochemistry & Molecular Biology

Nesprin 1 is critical for nuclear positioning and anchorage

Jianlin Zhang et al.

HUMAN MOLECULAR GENETICS (2010)

Article Biochemistry & Molecular Biology

Mammalian SUN Protein Interaction Networks at the Inner Nuclear Membrane and Their Role in Laminopathy Disease Processes

Farhana Haque et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Nesprin-2 Interacts with α-Catenin and Regulates Wnt Signaling at the Nuclear Envelope

Sascha Neumann et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Review Cell Biology

Nuclei Take a Position: Managing Nuclear Location

Brian Burke et al.

DEVELOPMENTAL CELL (2009)

Article Multidisciplinary Sciences

Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization

Kyle J. Roux et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice

Kai Lei et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Oncology

Wnt-signaling and senescence A tug of war in early neoplasia?

Peter D. Adams et al.

CANCER BIOLOGY & THERAPY (2008)

Article Cell Biology

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

Jesus Espada et al.

JOURNAL OF CELL BIOLOGY (2008)

Article Cell Biology

Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin

Yvonne Lueke et al.

JOURNAL OF CELL SCIENCE (2008)

Article Biochemistry & Molecular Biology

Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cells

Sebastian Kandert et al.

HUMAN MOLECULAR GENETICS (2007)

Article Multidisciplinary Sciences

Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations

Zhaohui Feng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

Structure of the human MutSα DNA lesion recognition complex

Joshua J. Warren et al.

MOLECULAR CELL (2007)

Article Multidisciplinary Sciences

Transmembrane protein Sun2 is involved in tethering mammalian meiotic telomeres to the nuclear envelope

Johannes Schmitt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Genetics & Heredity

Hutchinson-Gifford Progeria syndrome: Review of the phenotype

Raoul C. M. Hennekam

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2006)

Article Multidisciplinary Sciences

Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome

Kris Noel Dahl et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Physiology

Nuclear lamins: Laminopathies and their role in premature ageing

J. L. V. Broers et al.

PHYSIOLOGICAL REVIEWS (2006)

Article Biochemistry & Molecular Biology

A pericellular collagenase directs the 3-dimensional development of white adipose tissue

Tae-Hwa Chun et al.

Article Multidisciplinary Sciences

Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome

R Varga et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Cell Biology

Coupling of the nucleus and cytoplasm: role of the LINC complex

M Crisp et al.

JOURNAL OF CELL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Genomic instability in laminopathy-based premature aging

BH Liu et al.

NATURE MEDICINE (2005)

Article Anatomy & Morphology

Membrane-type 1 matrix metalloproteinase is required for normal alveolar development

JJ Atkinson et al.

DEVELOPMENTAL DYNAMICS (2005)

Review Biochemistry & Molecular Biology

Reactive oxygen species as mediators of cellular senescence

R Colavitti et al.

IUBMB LIFE (2005)

Article Multidisciplinary Sciences

A DNA damage checkpoint response in telomere-initiated senescence

FD di Fagagna et al.

NATURE (2003)

Article Multidisciplinary Sciences

Lamin A truncation in Hutchinson-Gilford progeria

A De Sandre-Giovannoli et al.

SCIENCE (2003)

Article Multidisciplinary Sciences

A progeroid syndrome in mice is caused by defects in A-type lamins

LC Mounkes et al.

NATURE (2003)

Review Biochemistry & Molecular Biology

Cancer and aging: a model for the cancer promoting effects of the aging stroma

A Krtolica et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2002)

Article Multidisciplinary Sciences

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect

MO Bergo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction

LW Elmore et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Review Oncology

Strategies for MMP inhibition in cancer:: Innovations for the post-trial era

CM Overall et al.

NATURE REVIEWS CANCER (2002)

Article Cardiac & Cardiovascular Systems

Smooth muscle cell depletion and collagen types in progeric arteries

WE Stehbens et al.

CARDIOVASCULAR PATHOLOGY (2001)

Article Multidisciplinary Sciences

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

ZJ Zhou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)