4.6 Article

Thymoquinone Radiosensitizes Human Colorectal Cancer Cells in 2D and 3D Culture Models

Related references

Note: Only part of the references are listed.
Review Oncology

Therapeutic potential of thymoquinone in combination therapy against cancer and cancer stem cells

Zaynab Fatfat et al.

Summary: The long-term success of standard anticancer monotherapeutic strategies has been limited by tolerability issues, treatment resistance, and cancer relapse. Combination therapy has shown promising results in strengthening the anti-tumor potential, reducing toxic effects, and overcoming resistance. Interest in combining natural products with conventional chemotherapeutics to improve treatment efficacy has been growing, with Thymoquinone (TQ) emerging as a promising candidate due to its low toxicity and anticancer efficacy.

WORLD JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Medicine, Research & Experimental

The combination effect of Prominin1 (CD133) suppression and Oxaliplatin treatment in colorectal cancer therapy

Zahra Asadzadeh et al.

Summary: The study demonstrated that silencing CD133 reduces the migration and stemness properties of colorectal cancer cells, making the cells more sensitive to Oxaliplatin and lowering the effective dose of the chemical drug. This suppression, when combined with Oxaliplatin treatment, could be a promising therapeutic approach in the treatment of colorectal cancer.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Oncology

Phosphorylated mTOR expression as a predictor of survival after liver resection for colorectal liver metastases

Takanori Konishi et al.

Summary: Phosphorylated mammalian target of rapamycin (p-mTOR) plays a crucial role in cancer progression, with high expression in colorectal liver metastases being associated with lower overall survival rates following liver resection. The activation of mTOR in colorectal liver metastases was frequently detected, and high p-mTOR expression was identified as a predictor for overall survival in these patients.

JOURNAL OF SURGICAL ONCOLOGY (2021)

Review Biochemistry & Molecular Biology

The PI3K/AKT/mTOR signaling pathway inhibitors enhance radiosensitivity in cancer cell lines

Alireza Mardanshahi et al.

Summary: Radiotherapy is a common cancer treatment modality that can activate the PI3K and AKT signaling pathway to enhance tumor cell radiosensitivity. By inhibiting downstream mediators like mTOR, combined with radiation, can increase malignant cell radiosensitivity through autophagy activation.

MOLECULAR BIOLOGY REPORTS (2021)

Article Oncology

γ-H2AX as a potential indicator of radiosensitivity in colorectal cancer cells

Satoshi Kawashima et al.

ONCOLOGY LETTERS (2020)

Article Biochemistry & Molecular Biology

Combinatorial therapy of Thymoquinone and Emodin synergistically enhances apoptosis, attenuates cell migration and reduces stemness efficiently in breast cancer

Mousumi Bhattacharjee et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2020)

Article Biology

Radiation-induced DNA damage response and resistance in colorectal cancer stem-like cells

Kumari Anuja et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2019)

Review Oncology

The Prognostic and Clinical Value of CD44 in Colorectal Cancer: A Meta-Analysis

Zhenpeng Wang et al.

FRONTIERS IN ONCOLOGY (2019)

Review Gastroenterology & Hepatology

Neoadjuvant radiotherapy for rectal cancer management

Gerard Feeney et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

Review Medicine, General & Internal

Colorectal cancer

Evelien Dekker et al.

LANCET (2019)

Review Pathology

Cancer stem cells in colorectal cancer: a review

Matthew J. Munro et al.

JOURNAL OF CLINICAL PATHOLOGY (2018)

Review Cell & Tissue Engineering

Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment

Lan Thi Hanh Phi et al.

STEM CELLS INTERNATIONAL (2018)

Article Oncology

An Update on Randomized Clinical Trials in Metastatic Colorectal Carcinoma

Naruhiko Ikoma et al.

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA (2017)

Article Gastroenterology & Hepatology

Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation

Hsi-Hsien Hsu et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2017)

Review Pharmacology & Pharmacy

Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment : Evidence from Preclinical Studies

A. G. M. Mostofa et al.

FRONTIERS IN PHARMACOLOGY (2017)

Review Oncology

Pharmacologic resistance in colorectal cancer: a review

William A. Hammond et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2016)

Article Gastroenterology & Hepatology

Antibody Against CD44s Inhibits Pancreatic Tumor Initiation and Postradiation Recurrence in Mice

Ling Li et al.

GASTROENTEROLOGY (2014)

Review Oncology

Current status of pharmacological treatment of colorectal cancer

Reyhan Akhtar et al.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2014)

Article Cell Biology

DNA Damage Sensing by the ATM and ATR Kinases

Alexandre Marechal et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Review Medicine, General & Internal

Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer

Laura De Caluwe et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2013)

Article Pharmacology & Pharmacy

Thymoquinone: Potential cure for inflammatory disorders and cancer

Chern Chiuh Woo et al.

BIOCHEMICAL PHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling

Nahed El-Najjar et al.

APOPTOSIS (2010)

Review Oncology

Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer

Sanjeev Banerjee et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2010)

Review Genetics & Heredity

Colon cancer stem cells

Lucia Ricci-Vitiani et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2009)

Article Biochemistry & Molecular Biology

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

Bunsyo Shiotani et al.

MOLECULAR CELL (2009)

Article Cell Biology

Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models

Hala Gali-Muhtasib et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2008)

Article Biochemistry & Molecular Biology

Irradiation-induced G2/M checkpoint response requires ERK1/2 activation

Y. Yan et al.

ONCOGENE (2007)

Article Pathology

CD44 promotes resistance to apoptosis in human colon cancer cells

M Lakshman et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2004)

Article Biochemistry & Molecular Biology

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.

IM Ward et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

S Burma et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)