4.7 Review

Efficacy of Different Doses of Daprodustat for Anemic Non-dialysis Patients with Chronic Kidney Disease: A Systematic Review and Network Meta-Analysis

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Efficacy and Safety of Daprodustat for Anemia Therapy in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis

Qiyan Zheng et al.

Summary: Daprodustat showed significant efficacy in treating anemia of chronic kidney disease patients, with no serious adverse events observed. It demonstrated favorable outcomes compared to placebo and rhEPO in terms of hemoglobin levels.

FRONTIERS IN PHARMACOLOGY (2021)

Article Urology & Nephrology

Daprodustat Compared with Epoetin Beta Pegol for Anemia in Japanese Patients Not on Dialysis: A 52-Week Randomized Open-Label Phase 3 Trial

Masaomi Nangaku et al.

Summary: The study showed that oral daprodustat was noninferior to CERA in achieving and maintaining target hemoglobin levels in Japanese ND patients. The mean hemoglobin levels in both treatment groups were within the target range, and there was no meaningful difference in the frequencies of adverse events.

AMERICAN JOURNAL OF NEPHROLOGY (2021)

Article Medicine, General & Internal

Daprodustat for the Treatment of Anemia in Patients Not Undergoing Dialysis

Ajay K. Singh et al.

Summary: This study compared the efficacy and safety of daprodustat and darbepoetin alfa in treating anemia in CKD patients not undergoing dialysis. The change in hemoglobin levels and cardiovascular outcomes were similar between the two groups during the study period.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Medicine, General & Internal

Anemia in Chronic Kidney Disease: From Pathophysiology and Current Treatments, to Future Agents

Jose Portoles et al.

Summary: Anemia is a common complication in chronic kidney disease (CKD) and is managed with iron supplements and erythropoiesis stimulating agents. Advances in treatment, such as the development of hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) and insights from recent clinical trials on iron supplementation, may change future treatment targets.

FRONTIERS IN MEDICINE (2021)

Article Hematology

A 24-Week Anemia Correction Study of Daprodustat in Japanese Dialysis Patients

Yoshiharu Tsubakihara et al.

THERAPEUTIC APHERESIS AND DIALYSIS (2020)

Article Urology & Nephrology

Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants on hemodialysis

Amy M. Meadowcroft et al.

CLINICAL KIDNEY JOURNAL (2019)

Review Biochemistry & Molecular Biology

Hypoxia-Inducible Factor and Its Role in the Management of Anemia in Chronic Kidney Disease

Joshua M. Kaplan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Pharmacology & Pharmacy

Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemias

Jennifer L. Ariazi et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2017)

Review Urology & Nephrology

Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors: A Potential New Treatment for Anemia in Patients With CKD

Nupur Gupta et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2017)

Editorial Material Urology & Nephrology

The Dawning of a New Day in CKD Anemia Care?

Colin R. Lenihan et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Article Urology & Nephrology

Four-Week Studies of Oral Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor GSK1278863 for Treatment of Anemia

Louis Holdstock et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Article Urology & Nephrology

A Novel Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial

Richard A. Brigandi et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2016)

Article Urology & Nephrology

Intravenous Versus Oral Iron Supplementation for the Treatment of Anemia in CKD: An Updated Systematic Review and Meta-analysis

Daniel Shepshelovich et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2016)

Review Pharmacology & Pharmacy

Pathophysiology and pharmacological targets of VEGF in diabetic macular edema

Stefano Fogli et al.

PHARMACOLOGICAL RESEARCH (2016)

Review Transplantation

The iron cycle in chronic kidney disease (CKD): from genetics and experimental models to CKD patients

Kimberly Zumbrennen-Bullough et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2014)

Article Pharmacology & Pharmacy

Effect of Food and Gemfibrozil on the Pharmacokinetics of the Novel Prolyl Hydroxylase Inhibitor GSK1278863

Brendan M. Johnson et al.

CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT (2014)

Article Urology & Nephrology

Cardiovascular Toxicity of Epoetin-Alfa in Patients with Chronic Kidney Disease

Peter A. McCullough et al.

AMERICAN JOURNAL OF NEPHROLOGY (2013)

Review Oncology

VEGF targets the tumour cell

Hira Lal Goel et al.

NATURE REVIEWS CANCER (2013)

Article Urology & Nephrology

Mechanisms of Anemia in CKD

Jodie L. Babitt et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)

Editorial Material Urology & Nephrology

Foreword

Bertram L. Kasiske et al.

KIDNEY INTERNATIONAL SUPPLEMENTS (2012)

Review Pathology

The HIF Pathway and Erythrocytosis

Frank S. Lee et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 6 (2011)

Article Multidisciplinary Sciences

Hepcidin Is Involved in Iron Regulation in the Ischemic Brain

Hui Ding et al.

PLOS ONE (2011)

Article Hematology

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

Pinelopi P. Kapitsinou et al.

BLOOD (2010)

Article Medicine, Research & Experimental

HIF-2α, but not HIF-1α, promotes iron absorption in mice

Maria Mastrogiannaki et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Review Transplantation

Potential mechanisms of adverse outcomes in trials of anemia correction with erythropoietin in chronic kidney disease

Nosratola D. Vaziri et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2009)

Article Medicine, General & Internal

A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease

Marc A. Pfeffer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Medicine, General & Internal

Correction of anemia with epoetin alfa in chronic kidney disease

Ajay K. Singh et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Medicine, General & Internal

Normalization of hemoglobin level in patients with chronic kidney disease and anemia

Tilman B. Drueke et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)