Journal
JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/jcm11092322
Keywords
cardiovascular disease; inflammation; psychobiology; risk factor; traumatic stress; depression
Categories
Funding
- Swiss National Science Foundation [140960]
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This study aimed to investigate whether self-reported history of depression is associated with a smaller decrease in CRP levels among patients with acute myocardial infarction (MI). The findings showed a significant association between depression history and a smaller decrease in CRP risk categories and log CRP levels over time. This highlights the importance of further research on whether reducing inflammation in MI patients with a history of depression can improve prognosis.
Background: Elevated levels of C-reactive protein (CRP) are associated with both an increased risk of cardiovascular disease (CVD) and depression. We aimed to test the hypothesis that a self-report history of depression is associated with a smaller decrease in CRP levels from hospital admission to 3-month follow-up in patients with acute myocardial infarction (MI). Methods: We assessed 183 patients (median age 59 years; 84% men) with verified MI for a self-report history of lifetime depression and plasma CRP levels within 48 h of an acute coronary intervention and again for CRP levels at three months. CRP values were categorized according to their potential to predict CVD risk at hospital admission (acute inflammatory response: 0 to <5 mg/L, 5 to <10 mg/L, 10 to <20 mg/L, and >= 20 mg/L) and at 3 months (low-grade inflammation: 0 to <1 mg/L, 1 to <3 mg/L, and >= 3 mg/L). Additionally, in a subsample of 84 patients showing admission CRP levels below 20 mg/L, changes in continuous CRP values over time were also analyzed. Results: After adjustment for a range of potentially important covariates, depression history showed a significant association with a smaller decrease in both CRP risk categories (r = 0.261, p < 0.001) and log CRP levels (r = 0.340, p = 0.005) over time. Conclusions: Self-reported history of depression may be associated with persistently elevated systemic inflammation three months after MI. This finding warrants studies to test whether lowering of inflammation in patients with an acute MI and a history of depression may improve prognosis.
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