Journal
JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/jcm11113164
Keywords
5-aminolevulinic acid patch; photodynamic therapy; PDT; daylight; treatment; actinic keratosis; actinic cheilitis; non-melanoma skin cancer
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Funding
- New National Excellence Program of the Ministry for Innovation and Technology from National Research, Development and Innovation Fund [UNKP-21-4-II-SE-10]
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Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) patch is an effective and well-tolerated treatment option for actinic keratosis (AK), as demonstrated in this case series study.
Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) is an emerging treatment option in the care of actinic keratosis (AK). A self-adhesive 5-ALA patch was recently developed that allows a precise PDT procedure. Here, we review the current literature and report the findings of our case series that observed the outcomes and safety of 5-ALA patch PDT. Ten patients with a total of 40 AKs were treated with a single session of conventional or daylight PDT using 5-ALA patch at the Department of Dermatology and Venereology, Sapienza University of Rome or at the European Institute of Oncology, Milan, Italy. Complete response was observed in three patients, while partial response was seen in seven patients. Overall tolerability was good or excellent, with local adverse events observed in four patients. This is the first case series reported where the 5-ALA patch was applied using daylight PDT, and its efficacy and tolerability in the treatment of AK were demonstrated. In conclusion, the self-adhesive 5-ALA patch is a convenient application of PDT that provides a well-tolerated and effective treatment option with satisfactory cosmetic outcomes.
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