Journal
JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/jcm11061507
Keywords
thiol-disulfide homeostasis; oxidative stress; antioxidants; skin disease
Categories
Funding
- Carol Davila University of Medicine and Pharmacy
Ask authors/readers for more resources
This article reviews the role of thiol-disulfide homeostasis (TDH) in various skin diseases. The results indicate that the changes in TDH may shift towards disulfides or thiols, depending on the extent of oxidative damage.
Oxidative stress represents the imbalance between oxidants and antioxidants and has been associated with a wide range of diseases. Thiols are the most important compounds in antioxidant defense. There is an equilibrium between thiols and their oxidized forms, disulfides, known as dynamic thiol-disulfide homeostasis (TDH). In 2014, Erel and Neselioglu developed a novel automated assay to measure thiol and disulfide levels. Subsequently, many researchers have used this simple, inexpensive and fast method for evaluating TDH in various disorders. We have reviewed the literature on the role of TDH in skin diseases. We identified 26 studies that evaluated TDH in inflammatory diseases (psoriasis, seborrheic dermatitis, atopic dermatitis, vitiligo, acne vulgaris and rosacea), allergic diseases (acute and chronic urticaria) and infectious diseases (warts, pityriasis rosea and tinea versicolor). The results are heterogeneous, but in most cases indicate changes in TDH that shifted toward disulfides or toward thiols, depending on the extent of oxidative damage.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available