Journal
JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/jcm11092479
Keywords
primary sclerosing cholangitis; biomarkers; soluble urokinase plasminogen activator receptor; liver cirrhosis
Categories
Funding
- German Research Foundation [DFG Si 1983/4-1, MU 2864/1-3, MU 2864/3-1, CRC 1382, 403224013, CRC/TR 296]
Ask authors/readers for more resources
suPAR is a biomarker that can be used for diagnosis and prediction of liver cirrhosis and acute cholangitis in patients with PSC, and it is not influenced by inflammatory bowel disease.
The soluble urokinase-type plasminogen activator receptor (suPAR) has evolved as a useful biomarker for different entities of chronic liver disease. However, its role in patients with primary sclerosing cholangitis (PSC) is obscure. We analyzed plasma levels of suPAR in 84 patients with PSC and compared them to 68 patients with inflammatory bowel disease (IBD) without PSC and to 40 healthy controls. Results are correlated with clinical records. suPAR concentrations were elevated in patients with PSC compared to patients with IBD only and to healthy controls (p < 0.001). Elevated suPAR levels were associated with the presence of liver cirrhosis (p < 0.001) and signs of portal hypertension (p < 0.001). suPAR revealed a high accuracy for the discrimination of the presence of liver cirrhosis comparable to previously validated noninvasive fibrosis markers (area under the curve (AUC) 0.802 (95%CI: 0.702-0.902)). Further, we demonstrated that suPAR levels may indicate the presence of acute cholangitis episodes (p < 0.001). Finally, despite the high proportion of PSC patients with IBD, presence of IBD and its disease activity did not influence circulating suPAR levels. suPAR represents a previously unrecognized biomarker for diagnosis and liver cirrhosis detection in patients with PSC. However, it does not appear to be confounded by intestinal inflammation in the context of IBD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available