4.7 Article

Perineural Invasion in Pancreatic Ductal Adenocarcinoma (PDAC): A Saboteur of Curative Intended Therapies?

Related references

Note: Only part of the references are listed.
Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Efficacy of Perioperative Chemotherapy for Resectable Pancreatic Adenocarcinoma A Phase 2 Randomized Clinical Trial

Davendra P. S. Sohal et al.

Summary: This study aimed to evaluate the 2-year overall survival rate of perioperative chemotherapy for resectable pancreatic ductal adenocarcinoma (PDA), but did not show significant improvement compared to historical data. The 2-year overall survival rates were 47% and 48% for the two treatment arms, demonstrating adequate safety and high resectability rates with perioperative chemotherapy, as well as challenges in quality control for resectability criteria.

JAMA ONCOLOGY (2021)

Article Medicine, General & Internal

Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma: Role of the Radiologist and Oncologist in the Era of Precision Medicine

Federica Vernuccio et al.

Summary: The article discusses the increasing incidence and mortality of pancreatic ductal adenocarcinoma over time, highlighting the importance of a multidisciplinary team in the management of patients. It also covers advancements in the molecular basis of the disease, diagnostic tools for staging, and the management of resectable or borderline resectable pancreatic cancer.

DIAGNOSTICS (2021)

Article Oncology

Pancreatic Adenocarcinoma, Version 2.2021

Margaret A. Tempero et al.

Summary: Pancreatic cancer is the fourth leading cause of cancer-related death in the United States, with a major challenge being advanced disease at diagnosis. While survival rates have not significantly changed, newer treatments, including targeted therapies, offer hope for patients. The manuscript focuses on systemic therapy approaches for locally advanced and metastatic disease.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2021)

Article Surgery

Impact of resection margin status on recurrence and survival in pancreatic cancer surgery

W. S. Tummers et al.

BRITISH JOURNAL OF SURGERY (2019)

Article Oncology

Microscopic Venous Invasion in Pancreatic Cancer

Mihoko Yamada et al.

ANNALS OF SURGICAL ONCOLOGY (2018)

Review Radiology, Nuclear Medicine & Medical Imaging

Pancreatic Adenocarcinoma Staging in the Era of Preoperative Chemotherapy and Radiation Therapy

Marc Zins et al.

RADIOLOGY (2018)

Article Medicine, General & Internal

FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer

T. Conroy et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Oncology

Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma

Rachelle E. Stopczynski et al.

CANCER RESEARCH (2014)

Article Medicine, General & Internal

Adjuvant Chemotherapy With Gemcitabine and Long-term Outcomes Among Patients With Resected Pancreatic Cancer The CONKO-001 Randomized Trial

Helmut Oettle et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

Article Medicine, General & Internal

Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid vs Gemcitabine Following Pancreatic Cancer Resection A Randomized Controlled Trial

John P. Neoptolemos et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2010)

Article Oncology

Consensus transcriptome signature of perineural invasion in pancreatic carcinoma

Ivane Abiatari et al.

MOLECULAR CANCER THERAPEUTICS (2009)

Article Gastroenterology & Hepatology

The nature of neural invasion by pancreatic cancer

Masato Kayahara et al.

PANCREAS (2007)