4.7 Article

Decreased Need for Correction Boluses with Universal Utilisation of Dual-Wave Boluses in Children with Type 1 Diabetes

Journal

JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 6, Pages -

Publisher

MDPI
DOI: 10.3390/jcm11061689

Keywords

type 1 diabetes; insulin pump therapy; CGM; meal bolus; dual wave bolus; standard bolus

Funding

  1. Estonian Reaserch Cauncil [PSG287, PRG 1428]

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The use of dual-wave boluses for evening meals based solely on the carbohydrate count did not improve time in range (TIR) in children with type 1 diabetes (T1D). However, it enabled significantly less correction boluses to achieve normal blood glucose levels in the morning compared to standard boluses.
Insulin pumps offer standard (SB), square and dual-wave boluses (DWB). Few recommendations exist on how to use these dosing options. Several studies suggest that the DWB is more effective for high-fat or high-carbohydrate meals. Our objective was to test whether time in range (TIR) improves in children with type 1 diabetes (T1D) using the universal utilization of the dual-wave boluses for all evening meals regardless of the composition of the meal. This was a 28-day long prospective randomized open-label single-center crossover study. Twenty-eight children with T1DM using a Medtronic 640G pump and continuous glucose monitoring system were randomly assigned to receive either DWB or SB for all meals starting from 6:00 p.m. based solely on the food carbohydrate count. DWB was set for 50/50% with the second part extended over 2 h. After two weeks patients switched into the alternative treatment arm. TIR (3.9-10 mmol/L), time below range (TBR) (<3.9 mmol/L) and time above range (TAR) (>10 mmol/L) and sensor glucose values were measured and compared between the groups. Twenty-four children aged 7-14 years completed the study according to the study protocol. There were no statistically significant differences in mean TIR (60.9% vs. 58.8%; p = 0.3), TBR (1.6% vs. 1.7%; p = 0.7) or TAR (37.5 vs. 39%; p = 0.5) between DWB and SB groups, respectively. Subjects in the SB treatment arm administered significantly less correction boluses between 6 p.m. and 6 a.m. compared to those in the DWB group (1.2 +/- 0.8 vs. 1.7 +/- 0.8, respectively; p < 0.01). DWB for evening meals in which insulin is calculated solely on the food carbohydrate content did not improve TIR compared to standard bolus in children with T1D. However, DWB enabled to use significantly less correction boluses to achieve euglycemia by the morning compared to the SB.

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