Journal
JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/jcm11102781
Keywords
custom allograft; pelvic tumour; massive allograft; tumour reconstruction; bone machining; GMP manufacturing; simulation; virtual planning
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Funding
- Italian Ministry of Health RETE RAMS [RCR-2021-23671217]
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By simulating the machining of massive bone allografts using different machines, the study showed that the robot outperformed the four-axes machine. This research paves the way for cleanroom machining of massive bone allografts, but further studies are needed.
The use of massive bone allografts after the resection of bone tumours is still a challenging process. However, to overcome some issues related to the processing procedures and guarantee the best three-dimensional matching between donor and recipient, some tissue banks have developed a virtual tissue database based on the scanning of the available allografts for using their 3D shape during virtual surgical planning (VSP) procedures. To promote the use of future VSP bone-shaping protocols useful for machining applications within a cleanroom environment, in our work, we simulate a massive bone allograft machining with two different machines: a four-axes (computer numerical control, CNC) vs. a five-axes (robot) milling machine. The allograft design was based on a real case of allograft reconstruction after pelvic tumour resection and obtained with 3D Slicer and Rhinoceros software. Machining simulations were performed with RhinoCAM and graphically and mathematically analysed with CloudCompare and R, respectively. In this case, the geometrical differences of the allograft design are not clinically relevant; however, the mathematical analysis showed that the robot performed better than the four-axes machine. The proof-of-concept presented here paves the way towards massive bone allograft cleanroom machining. Nevertheless, further studies, such as the simulation of different types of allografts and real machining on massive bone allografts, are needed.
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