4.7 Article

Searching for New Genetic Biomarkers of Axial Spondyloarthritis

Journal

JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 10, Pages -

Publisher

MDPI
DOI: 10.3390/jcm11102912

Keywords

spondyloarthritis; ankylosing spondylitis; SNP; genetic biomarker; extra-articular manifestations; uveitis; treatment effectiveness; biologics

Funding

  1. Wroclaw Medical University (Poland) [STM.A270.20.153]

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This study identified new biomarkers associated with the clinical presentation and treatment response in axSpA patients. SNPs can be used to identify high-risk patients and initiate early treatment.
Background: Axial spondyloarthritis (axSpA) is a chronic inflammatory condition of the spine. In addition to musculoskeletal symptoms, there are also extra-articular manifestations. The aim of this study was to search for new biomarkers associated with the clinical presentation and treatment response in axSpA patients. Methods: In this study, 106 axSpA patients and 110 healthy controls were enrolled. Six single-nucleotide polymorphisms (SNPs) were selected for genotyping: ERAP1 rs2287987, ERAP2 rs2549782, TNF rs1800629, TNFRSF1A rs767455, TNFRSF1B rs1061622, and FCGR2A rs1801274. Participants were examined at baseline and after 12 and 24 weeks of anti-TNF therapy. Results: SNPs associated with high axSpA initial activity were TNFRSF1A rs767455 and TNFRSF1B rs1061622 (p < 0.008). The ERAP1 rs2287987 AA genotype was more frequently observed in patients with enthesitis (AA vs. G+, p = 0.049), while the TNFRSF1B rs1061622 GG genotype was more common in participants with uveitis (GG vs. TT, p = 0.042). Potential in predicting anti-TNF treatment response was demonstrated by ERAP1 rs2287987, ERAP2 rs2549782, TNFRSF1B rs1061622, and FCGR2A rs1801274. Conclusions: SNPs can be used to identify patients at risk of severe disease to initiate treatment earlier. Genetic testing will allow clinicians to choose the right drug for the patient.

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