Journal
JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/jcm11113032
Keywords
COVID-19; prognosis; score; mortality; disposition; lung ultrasound
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This study assessed the utility of lung ultrasound (LUS) in the Emergency Department (ED) for prognostic stratification of COVID-19 patients. The findings showed that LUS had good performance in predicting hospitalization or death as the primary outcome. The integration of LUS with a clinical score further improved sensitivity. LUS can improve prognostic stratification and support standardized disposition decisions for unvaccinated COVID-19 patients in the ED.
In the Emergency Department (ED), the decision to hospitalize or discharge COVID-19 patients is challenging. We assessed the utility of lung ultrasound (LUS), alone or in association with a clinical rule/score. This was a multicenter observational prospective study involving six EDs (NCT046291831). From October 2020 to January 2021, COVID-19 outpatients discharged from the ED based on clinical judgment were subjected to LUS and followed-up at 30 days. The primary clinical outcome was a composite of hospitalization or death. Within 393 COVID-19 patients, 35 (8.9%) reached the primary outcome. For outcome prognostication, LUS had a C-index of 0.76 (95%CI 0.68-0.84) and showed good performance and calibration. LUS-based classification provided significant differences in Kaplan-Meier curves, with a positive LUS leading to a hazard ratio of 4.33 (95%CI 1.95-9.61) for the primary outcome. The sensitivity and specificity of LUS for primary outcome occurrence were 74.3% (95%CI 59.8-88.8) and 74% (95%CI 69.5-78.6), respectively. The integration of LUS with a clinical score further increased sensitivity. In patients with a negative LUS, the primary outcome occurred in nine (3.3%) patients (p < 0.001 vs. unselected). The efficiency for rule-out was 69.7%. In unvaccinated ED patients with COVID-19, LUS improves prognostic stratification over clinical judgment alone and may support standardized disposition decisions.
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