Journal
TRANSLATIONAL NEURODEGENERATION
Volume 11, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s40035-022-00305-1
Keywords
Mitophagy; Alzheimer's disease; PINK1; Tau; A beta
Categories
Funding
- National Natural Science Foundation of China [31929002, 92049107, 81801077]
- Innovative Research Groups of the National Natural Science Foundation of China [81721005]
- Youth Program of Wuhan Municipal Health Commission Foundation [WX18Q41]
- Technology and Innovation Commission of Shenzhen Municipality [JCYJ20210324141405014]
- Guangdong Basic and Applied Basic Research Foundation [2020B1515120017]
- Academic Frontier Youth Team Project from Huazhong University of Science and Technology
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Mitophagy disorders play a crucial role in the occurrence and development of Alzheimer's disease, and the interaction with Aβ or Tau pathology may cause neuronal damage and death. Elucidating the molecular mechanism of mitophagy and its role in AD may provide new insights into the etiology and mechanisms.
Accumulation of impaired mitochondria and energy metabolism disorders are non-negligible features of both aging and age-related neurodegeneration, including Alzheimer's disease (AD). A growing number of studies suggest that mitophagy disorders play an important role in AD occurrence and development. The interaction between mitophagy deficits and A beta or Tau pathology may form a vicious cycle and cause neuronal damage and death. Elucidating the molecular mechanism of mitophagy and its role in AD may provide insights into the etiology and mechanisms of AD. Defective mitophagy is a potential target for AD prevention and treatment.
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