4.7 Review

Current approaches of nanomedicines in the market and various stage of clinical translation

Related references

Note: Only part of the references are listed.
Article Oncology

Implications of nanotechnology for the treatment of cancer: Recent advances

Sergey G. Klochkov et al.

Summary: The use of nanoparticles in anticancer drugs improves safety and efficacy, with advantages such as effective targeting, delayed release, increased half-life, and reduced systemic toxicity. Nano-carriers have shown significant improvements in drug delivery compared to traditional administration, but there are still limitations in their clinical use.

SEMINARS IN CANCER BIOLOGY (2021)

Review Medicine, Research & Experimental

Nanodelivery Systems for Topical Management of Skin Disorders

Mingyue Cui et al.

Summary: Topical drug delivery has advantages over other routes, but the stratum corneum poses a challenge. Nanotechnology offers opportunities to overcome this challenge with nanocarriers like liposomes and nanoparticles. These formulations show potential in treating skin disorders, with further developments needed.

MOLECULAR PHARMACEUTICS (2021)

Review Oncology

Tumor protein p53 mutation in archived tumor samples from a 12-year survivor of stage 4 pancreatic ductal adenocarcinoma may predict long-term survival with DeltaRex-G: A case report and literature review

Michael Morse et al.

Summary: DeltaRex-G, a retroviral vector targeting collagen-matrix, has shown potential in treating pancreatic cancer. A study demonstrated complete remission in a patient treated with DeltaRex-G, even maintaining remission for 12 years after stopping therapy. Further research is ongoing to explore the potential benefits of DeltaRex-G in patients with advanced metastatic pancreatic cancer.

MOLECULAR AND CLINICAL ONCOLOGY (2021)

Editorial Material Microbiology

Nanomaterials arising amid antibiotic resistance

Weiwei Gao et al.

NATURE REVIEWS MICROBIOLOGY (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

Novel Experience in Hybrid Tracers Clinical Evaluation of Feasibility and Efficacy in Using ICG-99mTc Nanotop for Sentinel Node Procedure in Breast Cancer Patients

Gianpiero Manca et al.

Summary: The hybrid tracer ICG-Tc-99m Nanotop used for SLNB in breast cancer patients proved to be feasible, reliable, and safe, achieving excellent performance in both preoperative lymphatic mapping and intraoperative SLN detection.

CLINICAL NUCLEAR MEDICINE (2021)

Article Clinical Neurology

Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study

David Adams et al.

Summary: Hereditary transthyretin-mediated amyloidosis is a rare genetic disease caused by mutations in the TTR gene. Long-term treatment with patisiran, an RNA interference therapeutic, showed sustained efficacy and acceptable safety profile in patients with this condition, as demonstrated in a 12-month interim analysis of a global open-label extension study.

LANCET NEUROLOGY (2021)

Review Nanoscience & Nanotechnology

Inducing immune tolerance with dendritic cell-targeting nanomedicines

Anna Cifuentes-Rius et al.

Summary: Induced tolerogenic dendritic cells offer a promising immunotherapy for autoimmune diseases, with nanomedicine presenting an alternative approach to overcome cost and customization limitations. By targeting dendritic cells with nanoparticles, this technology has the potential to address critical issues in organ transplantation and prevalent autoimmune disorders.

NATURE NANOTECHNOLOGY (2021)

News Item Biotechnology & Applied Microbiology

Exosome-based candidates move into the clinic

Megan Cully

Summary: Exosomes, small extracellular vesicles shed by cells, have long been considered promising drug delivery systems for various biologic payloads, with the first ones now in clinical trials.

NATURE REVIEWS DRUG DISCOVERY (2021)

Editorial Material Nanoscience & Nanotechnology

Extracellular vesicles versus synthetic nanoparticles for drug delivery

Kenneth W. Witwer et al.

Summary: Cell-released biological nanoparticles, known as extracellular vesicles (EVs), are emerging drug carriers with high complexity. EV-based drug delivery leverages intrinsic mechanisms for molecular transport in the body, and integrating EV biology and manufacturing with clinical insights from synthetic nanoparticles is likely to significantly advance the field of drug delivery.

NATURE REVIEWS MATERIALS (2021)

Article Chemistry, Multidisciplinary

Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity

Zhiwan Wang et al.

Summary: This study presents an amphiphilic F-11-derivative-based oxygen-delivering polyfluorocarbon nanovehicle for cancer therapy, aiming to relieve tumor hypoxia and boost antitumor immunity. The optimized PF(11)DG nanovehicles showed enhanced tumor oxygenation and significant inhibition of tumor growth in breast and pancreatic cancer models, indicating promising therapeutic benefits.

ACS NANO (2021)

Review Pharmacology & Pharmacy

COVID-19 vaccines: The status and perspectives in delivery points of view

Jee Young Chung et al.

Summary: The COVID-19 pandemic, caused by SARS-CoV-2, has highlighted the urgent need for efficient and safe vaccines to prevent the spread of the virus and restore social and economic activities through mass immunization. Various vaccine candidates and alternative therapies are under development to combat the challenges presented by the disease.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Oncology

Exosome-based liquid biopsies in cancer: opportunities and challenges

W. Yu et al.

Summary: Liquid biopsy in cancer research has seen significant progress, with efforts focused on utilizing circulating tumor cells, circulating tumor DNA, and extracellular vesicles like exosomes. Exosomes, as part of the intercellular communication system, carry tumor-derived materials and can serve as stable biomarkers for early detection and monitoring of cancer.

ANNALS OF ONCOLOGY (2021)

Review Pharmacology & Pharmacy

A paradigm shift in cancer nanomedicine: from traditional tumor targeting to leveraging the immune system

Alexandros Marios Sofias et al.

Summary: The key is to rebalance the immune system by targeting, attracting, and modulating cancer-related immune cells, and rational design and application of nanomedicines can help achieve this. This not only benefits cancer therapy but also holds potential for treating other diseases.

DRUG DISCOVERY TODAY (2021)

Article Pharmacology & Pharmacy

Inclisiran: First Approval

Yvette N. Lamb

Summary: Inclisiran is a first-in-class cholesterol-lowering drug administered through subcutaneous injection, approved for use in patients with primary hypercholesterolaemia or mixed dyslipidaemia.

DRUGS (2021)

Review Pharmacology & Pharmacy

Current strategies for oral delivery of BCS IV drug nanocrystals: challenges, solutions and future trends

Yue Wang et al.

Summary: The oral absorption of BCS IV drug nanocrystals as a whole strategy is preferred, requiring both structural and surface modifications. Surface modification enhances the oral absorption of nanocrystals, promoting therapeutic effects.

EXPERT OPINION ON DRUG DELIVERY (2021)

Article Biochemistry & Molecular Biology

Mutational and biophysical robustness in a prestabilized monobody

Peter G. Chandler et al.

Summary: The FN3Con monobody is explored as a potential alternative to antibodies for therapeutic applications, due to its extreme stability and binding capabilities to therapeutic targets. Grafting binding loops from Adnectin-anti-VEGFR2 onto the prestabilized FN3Con scaffold resulted in a construct with high affinity binding to VEGFR2, maintaining both stability and activity. This strategy offers promise for the development of monobody domains with desirable biophysical characteristics.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Review Chemistry, Multidisciplinary

Nanomedicines accessible in the market for clinical interventions

Vedant Gadekar et al.

Summary: Nanomedicines, also known as nano-pharmaceuticals, have shown great potential in improving therapeutic efficacy and reducing side effects. Despite a considerable market share, challenges such as safety, regulatory hurdles, and cost need to be addressed for their market entry. This review discusses the current market status, challenges, and potential of nanomedicines.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Immunology

Variant SARS-CoV-2 mRNA vaccines confer broad neutralization as primary or booster series in mice

Kai Wu et al.

Summary: The study evaluated the efficacy of two updated mRNA vaccines targeting SARS-CoV-2 variants in mice. The vaccine based on B.1.351 was effective at increasing neutralizing antibody titers, while the 1:1 mix vaccine provided broad cross-variant neutralization. A third dose of vaccine significantly increased neutralization titers.

VACCINE (2021)

Review Nanoscience & Nanotechnology

Targeted drug delivery strategies for precision medicines

Mandana T. Manzari et al.

Summary: Precision medicine offers personalized treatment strategies for individual patients, especially in the field of cancer therapy. While there have been some clinical successes, challenges such as drug toxicities and resistance still hinder the full potential of precision medicine. Advanced drug delivery materials and approaches provide opportunities to improve therapeutic outcomes and overcome pharmacological issues in cancer treatment.

NATURE REVIEWS MATERIALS (2021)

Review Biotechnology & Applied Microbiology

Cell therapies in the clinic

Lily Li-Wen Wang et al.

Summary: Cell therapies have emerged as a promising therapeutic modality with unique advantages over conventional drugs, expanding therapeutic options and processes. They are currently a focus of investigation in both preclinical and clinical settings, with numerous approved products and ongoing clinical trials.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2021)

Article Chemistry, Multidisciplinary

Engineering a Second-Order DNA Logic-Gated Nanorobot to Sense and Release on Live Cell Membranes for Multiplexed Diagnosis and Synergistic Therapy

Dan Wang et al.

Summary: This study introduces a novel DNA tetrahedral scaffold that can load multiple aptamers and therapeutics for precise and effective cancer therapy. The technology enables precise discrimination among different cell lines and synergistic killing of cancer cells through effector aptamer-tethered synergistic drugs.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Review Biochemistry & Molecular Biology

Delivery routes matter: Safety and efficacy of intratumoral immunotherapy

Emily De Lombaerde et al.

Summary: Direct intratumoral injection allows for local immune activation, leading to decreased systemic toxicity, improved efficacy, and abscopal effects. The approval of the first intratumoral oncolytic virotherapy, talimogene laherparepvec (T-VEC), has sparked interest in studying other immunotherapeutic approaches.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

Article Oncology

Safety and antibody immune response of CHP-NY-ESO-1 vaccine combined with poly-ICLC in advanced or recurrent esophageal cancer patients

Takeshi Ishikawa et al.

Summary: The vaccine combining CHP-NY-ESO-1 and poly-ICLC showed good safety and immune response in a phase 1 clinical trial, with no observed tumor responses. All patients achieved antibody responses, with higher titers in the combination group.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Review Chemistry, Multidisciplinary

The progress and perspective of strategies to improve tumor penetration of nanomedicines

Jiang Hu et al.

Summary: This article discusses the importance of tumor penetration, analyzes the barriers to tumor penetration, and discusses strategies such as modulating the tumor microenvironment to enhance tumor penetration.

CHINESE CHEMICAL LETTERS (2021)

Review Biochemistry & Molecular Biology

Antibody-Drug Conjugates-A Tutorial Review

Stephanie Baah et al.

Summary: ADCs are a family of targeted therapeutic agents for cancer treatment, with over 80 currently in clinical development and 11 approved by the FDA. They offer enhanced targeting of cancer cells and reduced toxic side effects compared to traditional approaches, making them an attractive prospect in oncology research.

MOLECULES (2021)

Article Multidisciplinary Sciences

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

Prabhu S. Arunachalam et al.

Summary: This study demonstrated the effectiveness of an adjuvanted RBD-NP vaccine in inducing robust and durable neutralizing antibody responses, providing protection against SARS-CoV-2 infection, and cross-neutralizing various variants. Adjuvants such as AS03 and AS37 significantly enhanced the immunogenicity of the vaccine and have the potential to be candidates for COVID-19 vaccines.

NATURE (2021)

Review Immunology

Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines

Thai Thanh Hoang Thi et al.

Summary: This review highlights the importance of lipid-based nanoparticles in the development of COVID-19 vaccines and other nanomedicines, focusing on innovations that have obtained regulatory approval or are in clinical trials. It also discusses the physicochemical properties required for specific applications, emphasizes the differences in requirements for delivering different cargos, and introduces current challenges that need further development.

VACCINES (2021)

Review Biochemistry & Molecular Biology

Nanobodies for Medical Imaging: About Ready for Prime Time?

Lea Berland et al.

Summary: Recent advances in medical treatments, particularly for cancer patients, have significantly increased life expectancies for many patients with advanced or metastatic cancers. However, challenges remain for patients who do not respond well to treatments or experience toxic side effects. Studying cellular and molecular mechanisms underlying variable treatment responses is crucial for developing more effective therapeutics. Non-invasive imaging techniques, such as immuno-PET with nanobodies, offer promising opportunities for precise targeting and whole-body information.

BIOMOLECULES (2021)

Article Biology

ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance

Su Chul Jang et al.

Summary: CDN agonists of the STING pathway show immune activation and tumor clearance, but intratumorally administered CDNs can also cause cytotoxicity, inflammation, and immune ablation. ExoSTING, an engineered EV loaded with CDN, enhances efficacy and preferentially activates antigen presenting cells in the TME, leading to enhanced local and systemic anti-tumor immunity while avoiding systemic inflammatory responses.

COMMUNICATIONS BIOLOGY (2021)

Article Engineering, Biomedical

Reappraisal of anticancer nanomedicine design criteria in three types of preclinical cancer models for better clinical translation

Xin Luan et al.

Summary: The study investigates the design criteria of nanomedicines in different preclinical cancer models, revealing factors for better clinical translations of efficacy/safety. Short-circulating nanomedicines show potential advantages over long-circulating nanomedicines in certain aspects.

BIOMATERIALS (2021)

Article Oncology

Phase I, First-in-Human Study of the Probody Therapeutic CX-2029 in Adults with Advanced Solid Tumor Malignancies

Melissa Johnson et al.

Summary: PROCLAIM-CX-2029 is a phase I clinical trial evaluating the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of CX-2029 in adults with advanced solid tumors. The study demonstrated that CX-2029 can achieve clinical activity at a dose of 3mg/kg with confirmed partial responses in patients.

CLINICAL CANCER RESEARCH (2021)

Article Pharmacology & Pharmacy

Loncastuximab Tesirine: First Approval

Arnold Lee

Summary: Loncastuximab tesirine is an antibody-drug conjugate developed for the treatment of B cell lymphomas, currently approved in the US for specific types of lymphoma treatment while being researched for treatments of other types of lymphoma.

DRUGS (2021)

Article Chemistry, Multidisciplinary

Liposomal encapsulation of trans-crocetin enhances oxygenation in patients with COVID-19-related ARDS receiving mechanical ventilation

Paul-Michel Mertes et al.

Summary: LEAF-4L6715, a novel therapy for COVID-19, has shown promising results in improving oxygenation and clinical outcomes. Preclinical studies demonstrated enhanced effects and increased half-life of the drug in animal models, highlighting its therapeutic potential for severely impacted patients.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Chemistry, Physical

Obstacles and opportunities in a forward vision for cancer nanomedicine

Irene de Lazaro et al.

Summary: This text discusses the biological barriers that have hindered the clinical translation of cancer nanomedicines, and elaborates on new directions for the field that capitalize on a deeper understanding of the nano-bio interface.

NATURE MATERIALS (2021)

Editorial Material Biochemistry & Molecular Biology

A first step toward in vivo gene editing in patients

Hildegard Buening et al.

Summary: The first preliminary evidence of in vivo gene editing in a clinical setting is feasible with no early signs of severe adverse events comes from an ongoing clinical trial to treat transthyretin amyloidosis, a fatal monogenetic disease.

NATURE MEDICINE (2021)

Review Nanoscience & Nanotechnology

Extracellular vesicles as a next-generation drug delivery platform

Inge Katrin Herrmann et al.

Summary: Extracellular vesicles play a crucial role in cell-to-cell communication and can serve as drug carriers with advantages over synthetic carriers. However, clinical translation of extracellular vesicle-based therapies remains challenging, requiring further research and development efforts.

NATURE NANOTECHNOLOGY (2021)

Article Medicine, General & Internal

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

Julian D. Gillmore et al.

Summary: The gene-editing therapeutic agent NTLA-2001 effectively reduced serum TTR protein concentrations in patients with ATTR amyloidosis, showing potential safety and pharmacodynamic effects in clinical studies.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Engineering, Biomedical

Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance

Yongheng Wang et al.

Summary: Nanoparticles releasing an oxaliplatin prodrug and a cationic DNA intercalator within temozolomide-resistant gliomas inhibit tumor growth without causing detectable toxicity. Combining anticancer drugs with distinct mechanisms of action, selective drug release, and convection-enhanced delivery may represent a translational strategy for the treatment of TMZ-resistant gliomas.

NATURE BIOMEDICAL ENGINEERING (2021)

Review Medicine, General & Internal

Nanomedicine: A Diagnostic and Therapeutic Approach to COVID-19

Arjun Sharma et al.

Summary: The SARS-CoV-2 virus is causing severe morbidity and mortality worldwide, and nanomedicine approaches have the potential to enhance conventional diagnostics, drugs, and vaccines. Nanoparticles in the nanometer scale can directly interact with and disrupt the structure of viruses, potentially preventing replication within the host.

FRONTIERS IN MEDICINE (2021)

Review Oncology

Clinical Utility of Pegaspargase in Children, Adolescents and Young Adult Patients with Acute Lymphoblastic Leukemia: A Review

Cynthia Bender et al.

Summary: Acute lymphoblastic leukemia (ALL) is a common hematological malignancy in children, with significant improvements in survival rates attributed to the use of asparaginases, particularly pegaspargase, which offers longer half-life and better immunogenicity since the 1960s.

BLOOD AND LYMPHATIC CANCER-TARGETS AND THERAPY (2021)

Review Oncology

Therapeutic cancer vaccines

Mansi Saxena et al.

Summary: Therapeutic cancer vaccines aim to induce tumor regression, eradicate minimal residual disease, establish lasting anti-tumor memory, and avoid non-specific or adverse reactions. However, challenges arise due to tumor-induced immunosuppression and immunoresistance, hindering the achievement of these goals.

NATURE REVIEWS CANCER (2021)

Review Oncology

The Changing Landscape of Therapeutic Cancer Vaccines-Novel Platforms and Neoantigen Identification

Jessica Jou et al.

Summary: Therapeutic cancer vaccines aim to create and enhance tumor-specific T-cell responses, but face challenges in achieving success. Researchers are exploring various strategies to overcome immunosuppressive mechanisms in the tumor microenvironment, improve vaccine delivery platforms, and utilize combination therapies.

CLINICAL CANCER RESEARCH (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

The superior predictive value of 166Ho-scout compared with 99mTc-macroaggregated albumin prior to 166Ho-microspheres radioembolization in patients with liver metastases

Maarten L. J. Smits et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2020)

Article Chemistry, Multidisciplinary

Enhancing Triple Negative Breast Cancer Immunotherapy by ICG-Templated Self-Assembly of Paclitaxel Nanoparticles

Bing Feng et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Ophthalmology

Can postoperative dexamethasone nanoparticle eye drops replace mitomycin C in trabeculectomy?

Gauti Johannesson et al.

ACTA OPHTHALMOLOGICA (2020)

Review Chemistry, Medicinal

Albumin nanoscience: homing nanotechnology enabling targeted drug delivery and therapy

Shrawani Lamichhane et al.

ARCHIVES OF PHARMACAL RESEARCH (2020)

Review Biochemical Research Methods

Trends in Therapeutic Conjugates: Bench to Clinic

Arnab Rudra et al.

BIOCONJUGATE CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

Nanoparticles-mediated reoxygenation strategy relieves tumor hypoxia for enhanced cancer therapy

Hong Wang et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Review Chemistry, Analytical

Recent advances in the bioanalytical methods of polyethylene glycols and PEGylated pharmaceuticals

Zhi Zhang et al.

JOURNAL OF SEPARATION SCIENCE (2020)

Review Polymer Science

Antibody drug conjugates: Development, characterization, and regulatory considerations

Nagavendra Kommineni et al.

POLYMERS FOR ADVANCED TECHNOLOGIES (2020)

Review Pharmacology & Pharmacy

Extracellular vesicles as drug delivery systems: Why and how?

Omnia M. Elsharkasy et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Article Pharmacology & Pharmacy

Recent advances in inhalable liposomes for treatment of pulmonary diseases: Concept to clinical stance

Piyush P. Mehta et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

Review Acoustics

THREE DECADES OF ULTRASOUND CONTRAST AGENTS: A REVIEW OF THE PAST, PRESENT AND FUTURE IMPROVEMENTS

Peter Frinking et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2020)

Editorial Material Chemistry, Physical

Active transcytosis and new opportunities for cancer nanomedicine

Subehndu Pandit et al.

NATURE MATERIALS (2020)

Review Pharmacology & Pharmacy

Liposomes: Advancements and innovation in the manufacturing process

Sanket Shah et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Review Pharmacology & Pharmacy

Translational considerations in nanomedicine: The oncology perspective

Alberto A. Gabizon et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Review Pharmacology & Pharmacy

Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals

Gergely Tibor Kozma et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Article Biochemistry & Molecular Biology

Improving the Treatment of Acute Lymphoblastic Leukemia

Ashish Radadiya et al.

BIOCHEMISTRY (2020)

Review Pharmacology & Pharmacy

The progress and perspective of nanoparticle-enabled tumor metastasis treatment

Wei Zhang et al.

ACTA PHARMACEUTICA SINICA B (2020)

Article Oncology

Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment

Susannah L. Hewitt et al.

CLINICAL CANCER RESEARCH (2020)

Article Cell Biology

Two-miRNA-based finger-stick assay for estimation of absorbed ionizing radiation dose

Marshleen Yadav et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Review Oncology

Aspartate β-hydroxylase as a target for cancer therapy

Madiha Kanwal et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Review Nanoscience & Nanotechnology

A framework for designing delivery systems

Wilson Poon et al.

NATURE NANOTECHNOLOGY (2020)

Review Chemistry, Multidisciplinary

Progress, challenges, and future of nanomedicine

Chenyang Zhang et al.

NANO TODAY (2020)

Review Materials Science, Biomaterials

Emerging antibacterial nanomedicine for enhanced antibiotic therapy

Shuting Wang et al.

BIOMATERIALS SCIENCE (2020)

Article Chemistry, Physical

Sustainable technologies for liposome preparation

Maja Leitgeb et al.

JOURNAL OF SUPERCRITICAL FLUIDS (2020)

Review Chemistry, Multidisciplinary

Clinical cancer nanomedicine

Joy Wolfram et al.

NANO TODAY (2019)

Review Immunology

Turning the corner on therapeutic cancer vaccines

Robert E. Hollingsworth et al.

NPJ VACCINES (2019)

Review Oncology

Cancer DNA vaccines: current preclinical and clinical developments and future perspectives

Alessandra Lopes et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Article Nanoscience & Nanotechnology

Enzyme-activatable polymer-drug conjugate augments tumour penetration and treatment efficacy

Quan Zhou et al.

NATURE NANOTECHNOLOGY (2019)

Article Chemistry, Multidisciplinary

Prolonged Release and Functionality of Interleukin-10 Encapsulated within PLA-PEG Nanoparticles

Skyla A. Duncan et al.

NANOMATERIALS (2019)

Review Chemistry, Multidisciplinary

Advanced Nanotechnology Leading the Way to Multimodal Imaging-Guided Precision Surgical Therapy

Cong Wang et al.

ADVANCED MATERIALS (2019)

Review Medicine, General & Internal

Antibody-drug conjugates for cancer

Cindy H. Chau et al.

LANCET (2019)

Review Biotechnology & Applied Microbiology

Current outlook on radionuclide delivery systems: from design consideration to translation into clinics

Oleksii O. Peltek et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

Article Nanoscience & Nanotechnology

Smart cancer nanomedicine

Roy van der Meel et al.

NATURE NANOTECHNOLOGY (2019)

Review Chemistry, Multidisciplinary

Cancer Modeling-on-a-Chip with Future Artificial Intelligence Integration

Kirsten Lee Fetah et al.

SMALL (2019)

Review Immunology

Engineered T Cell Therapy for Cancer in the Clinic

Lijun Zhao et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Chemistry, Multidisciplinary

Nanomedicines Lost in Translation

Keegan Guidolin et al.

ACS NANO (2019)

Review Biotechnology & Applied Microbiology

Nanopharmaceuticals and nanomedicines currently on the market: challenges and opportunities

Fatemeh Farjadian et al.

NANOMEDICINE (2019)

Article Nanoscience & Nanotechnology

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akin Akinc et al.

NATURE NANOTECHNOLOGY (2019)

Review Nanoscience & Nanotechnology

Fundamentals, challenges, and nanomedicine-based solutions for ocular diseases

Dadi A. Srinivasarao et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2019)

Review Biotechnology & Applied Microbiology

Nanoparticles in the clinic: An update

Aaron C. Anselmo et al.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2019)

Review Critical Care Medicine

The Current State of Topical Burn Treatments: a Review

Danielle LaSalle Hashmi et al.

CURRENT TRAUMA REPORTS (2019)

Article Nanoscience & Nanotechnology

Activation of innate immunity in primary human cells using a plant virus derived nanoparticle TLR7/8 agonist

Damien Carignan et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

Review Pharmacology & Pharmacy

Current developments and applications of microfluidic technology toward clinical translation of nanomedicines

Dongfei Liu et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Article Pharmacology & Pharmacy

Tumor targeting via EPR: Strategies to enhance patient responses

Susanne K. Golombek et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Review Chemistry, Multidisciplinary

Block Copolymer Micelles in Nanomedicine Applications

Horacio Cabral et al.

CHEMICAL REVIEWS (2018)

Review Chemistry, Multidisciplinary

Dendrimers in combination with natural products and analogues as anti-cancer agents

Serge Mignani et al.

CHEMICAL SOCIETY REVIEWS (2018)

Review Oncology

Oncorine, the World First Oncolytic Virus Medicine and its Update in China

Min Liang

CURRENT CANCER DRUG TARGETS (2018)

Review Pharmacology & Pharmacy

Facilitating the translation of nanomedicines to a clinical product: challenges and opportunities

Vibhuti Agrahari et al.

DRUG DISCOVERY TODAY (2018)

Editorial Material Pharmacology & Pharmacy

Can early intervention with pharmacotherapy reduce the morbidity and mortality of chronic lymphocytic leukemia?

Shuo Ma et al.

EXPERT OPINION ON PHARMACOTHERAPY (2018)

Review Biotechnology & Applied Microbiology

The First Approved Gene Therapy Product for Cancer Ad-p53 (Gendicine): 12 Years in the Clinic

Wei-Wei Zhang et al.

HUMAN GENE THERAPY (2018)

Review Chemistry, Multidisciplinary

Immunoliposomes in clinical oncology: State of the art and future perspectives

Maria Merino et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Review Biotechnology & Applied Microbiology

mRNA vaccines - a new era in vaccinology

Norbert Pardi et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Medicine, General & Internal

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

D. Adams et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Pharmacology & Pharmacy

Harnessing albumin as a carrier for cancer therapies

Ella N. Hoogenboezem et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Review Chemistry, Multidisciplinary

Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis

Zhiwen Zhang et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

Review Pharmacology & Pharmacy

Quality by design (QbD) approaches in current pharmaceutical set-up

Vijay Mishra et al.

EXPERT OPINION ON DRUG DELIVERY (2018)

News Item Biotechnology & Applied Microbiology

Alnylam launches era of RNAi drugs

Ken Garber

NATURE BIOTECHNOLOGY (2018)

Editorial Material Oncology

Exploiting Oncogenic Drivers along the CCNG1 Pathway for Cancer Therapy and Gene Therapy

Ahmad Al-Shihabi et al.

MOLECULAR THERAPY-ONCOLYTICS (2018)

Article Dermatology

Talimogene Laherparepvec (T-VEC) and Other Oncolytic Viruses for the Treatment of Melanoma

Praveen K. Bommareddy et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2017)

Review Oncology

Recent advances of bispecific antibodies in solid tumors

Shengnan Yu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

Article Clinical Neurology

Convection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies

Arman Jahangiri et al.

JOURNAL OF NEUROSURGERY (2017)

Review Pharmacology & Pharmacy

Application of quality by design in the current drug development

Lan Zhang et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

Review Oncology

Oncolytic viral Therapy for Mesothelioma

Daniel F. Pease et al.

FRONTIERS IN ONCOLOGY (2017)

Article Multidisciplinary Sciences

Antibody-targeted paclitaxel loaded nanoparticles for the treatment of CD20+ B-cell lymphoma

Wendy K. Nevala et al.

SCIENTIFIC REPORTS (2017)

Review Pharmacology & Pharmacy

Safety and Toxicological Considerations of Nanomedicines: The Future Directions

Parmi Patel et al.

CURRENT CLINICAL PHARMACOLOGY (2017)

Review Oncology

Cancer nanomedicine: progress, challenges and opportunities

Jinjun Shi et al.

NATURE REVIEWS CANCER (2017)

Review Oncology

Transport of drugs from blood vessels to tumour tissue

Mark W. Dewhirst et al.

NATURE REVIEWS CANCER (2017)

Review Biotechnology & Applied Microbiology

Bioengineering bacterial outer membrane vesicles as vaccine platform

Matthias J. H. Gerritzen et al.

BIOTECHNOLOGY ADVANCES (2017)

Review Pharmacology & Pharmacy

Liposomes for Pulmonary Drug Delivery: The Role of Formulation and Inhalation Device Design

Abdelbary Elhissi

CURRENT PHARMACEUTICAL DESIGN (2017)

Review Pharmacology & Pharmacy

Challenges and strategies in anti-cancer nanomedicine development: An industry perspective

Jennifer I. Hare et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

Editorial Material Pharmacology & Pharmacy

A Quality by Design Approach to Developing and Manufacturing Polymeric Nanoparticle Drug Products

Greg Troiano et al.

AAPS JOURNAL (2016)

Article Biotechnology & Applied Microbiology

Preclinical Justification of pbi-shRNA EWS/FLI1 Lipoplex (LPX) Treatment for Ewing's Sarcoma

Donald D. Rao et al.

MOLECULAR THERAPY (2016)

News Item Multidisciplinary Sciences

Bankruptcy of nanomedicine firm worries drug developers

Heidi Ledford

NATURE (2016)

Review Chemistry, Multidisciplinary

Peptide-based synthetic vaccines

Mariusz Skwarczynski et al.

CHEMICAL SCIENCE (2016)

Review Chemistry, Medicinal

Drug-loaded erythrocytes: on the road toward marketing approval

Vanessa Bourgeaux et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2016)

Article Immunology

Talimogene laherparepvec (T-VEC) for the treatment of advanced melanoma

Douglas B. Johnson et al.

IMMUNOTHERAPY (2015)

Review Biochemistry & Molecular Biology

Long Non-Coding RNAs as Master Regulators in Cardiovascular Diseases

Krystal Archer et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Article Biochemical Research Methods

Surface chemistry and serum type both determine the nanoparticle-protein corona

Daniela Pozzi et al.

JOURNAL OF PROTEOMICS (2015)

Review Oncology

Radioimmunotherapy of human tumours

Steven M. Larson et al.

NATURE REVIEWS CANCER (2015)

Review Chemistry, Multidisciplinary

Respirable nanocarriers as a promising strategy for antitubercular drug delivery

Mohammed M. Mehanna et al.

JOURNAL OF CONTROLLED RELEASE (2014)

Article Chemistry, Multidisciplinary

Issues and concerns in nanotech product development and its commercialization

Indu Pal Kaur et al.

JOURNAL OF CONTROLLED RELEASE (2014)

Article Multidisciplinary Sciences

Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA

Jonathan E. Zuckerman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Cell Biology

Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe

Evan Phillips et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Article Respiratory System

Inhaled liposomal amikacin

Valerie Waters et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2014)

Review Chemistry, Multidisciplinary

Future of the Particle Replication in Nonwetting Templates (PRINT) Technology

Jing Xu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

Article Pharmacology & Pharmacy

Discontinued drugs in 2011: oncology drugs

Robert Williams

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2013)

Article Biochemistry & Molecular Biology

Materials Characterization of Feraheme/Ferumoxytol and Preliminary Evaluation of Its Potential for Magnetic Fluid Hyperthermia

John P. Bullivant et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Review Chemistry, Multidisciplinary

Albumin-based nanoparticles as potential controlled release drug delivery systems

Ahmed O. Elzoghby et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Review Chemistry, Multidisciplinary

Doxil® - The first FDA-approved nano-drug: Lessons learned

Yechezkel (Chezy) Barenholz

JOURNAL OF CONTROLLED RELEASE (2012)

Review Biotechnology & Applied Microbiology

Liposomal preparation by supercritical fluids technology

J. Zhong et al.

AFRICAN JOURNAL OF BIOTECHNOLOGY (2011)

Editorial Material Pharmacology & Pharmacy

Clinical overview on Lipoplatin™: a successful liposomal formulation of cisplatin

Teni Boulikas

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)

Article Biochemical Research Methods

Novel prodrugs of SN38 using multiarm poly(ethylene glycol) linkers

Hong Zhao et al.

BIOCONJUGATE CHEMISTRY (2008)

Article Hematology

Safety and pharmacokinetics of a recombinant factor VIII with pegylated liposomes in severe hemophilia A

J. S. Powell et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2008)

Meeting Abstract Gastroenterology & Hepatology

Contrast-Enhanced EUS (CE-EUS) Using a New Microbubble Contrast Agent (MRX-815) - A Feasibility Study in a Porcine Model

Robert F. Wong et al.

GASTROINTESTINAL ENDOSCOPY (2006)

Article Clinical Neurology

Imaging-guided convection-enhanced delivery and gene therapy of glioblastoma

J Voges et al.

ANNALS OF NEUROLOGY (2003)