4.7 Article

Combining SJ733, an oral ATP4 inhibitor of Plasmodium falciparum, with the pharmacokinetic enhancer cobicistat: An innovative approach in antimalarial drug development

Related references

Note: Only part of the references are listed.
Article Infectious Diseases

Similarly efficacious anti-malarial drugs SJ733 and pyronaridine differ in their ability to remove circulating parasites in mice

Arya SheelaNair et al.

Summary: This study compared the effects of different anti-malarial drugs on mice infected with malaria. The results showed that different drugs varied in their ability to reduce parasite count and had different mechanisms of action. This suggests that although the parasite clearance curves may be similar, the drugs have different capacities to inhibit, kill, and clear parasites.

MALARIA JOURNAL (2022)

Article Infectious Diseases

Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones

Yizhe Chen et al.

Summary: SJ733 was selected as the clinical candidate over SJ311 due to its higher permeability and more favorable dose proportionality of exposure in mice, rats, and dogs. SJ311 had lower oral bioavailability and higher renal clearance, suggesting less favorable exposure in humans. SJ311 also displayed a narrower range of dose-proportional exposure, with plasma exposure flattening at doses above 200 mg/kg.

MALARIA JOURNAL (2021)

Review Pharmacology & Pharmacy

Malaria PK/PD and the Role Pharmacometrics Can Play in the Global Health Arena: Malaria Treatment Regimens for Vulnerable Populations

Emma Hughes et al.

Summary: Pharmacokinetic/pharmacodynamic models can optimize antimalarial dosing recommendations for vulnerable populations like children and pregnant women. Integrating PK data into clinical studies and incorporating drug resistance and host immunity data into PK/PD models can further improve malaria treatment outcomes.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

Article Medicine, General & Internal

Evidence of Artemisinin-Resistant Malaria in Africa

Betty Balikagala et al.

Summary: Research conducted in Northern Uganda revealed the emergence of artemisinin-resistant Plasmodium falciparum strains, with predominant mutations found in the kelch13 gene. Thirteen patients were infected with P. falciparum parasites carrying mutations in the A675V or C469Y allele, which were associated with prolonged parasite clearance half-lives.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Biochemistry & Molecular Biology

Pharmacokinetics and pharmacodynamics of cytochrome P450 inhibitors for HIV treatment

Yuqing Gong et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2019)

Review Infectious Diseases

New developments in anti-malarial target candidate and product profiles

Jeremy N. Burrows et al.

MALARIA JOURNAL (2017)

Article Medicine, General & Internal

Malaria

Margaret A. Phillips et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Article Pharmacology & Pharmacy

Artemether-lumefantrine co-administration with antiretrovirals: population pharmacokinetics and dosing implications

Richard M. Hoglund et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2015)

Review Pharmacology & Pharmacy

Cobicistat: Review of a Pharmacokinetic Enhancer for HIV Infection

Elizabeth M. Sherman et al.

CLINICAL THERAPEUTICS (2015)

Review Parasitology

The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs

Natalie Jane Spillman et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE (2015)

Article Medicine, General & Internal

Spiroindolone KAE609 for Falciparum and Vivax Malaria

Nicholas J. White et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Multidisciplinary Sciences

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

Maria Belen Jimenez-Diaz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Pharmacology & Pharmacy

Ways to fit a PK model with some data below the quantification limit

SL Beal

JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2001)