Journal
JOURNAL FOR IMMUNOTHERAPY OF CANCER
Volume 10, Issue 3, Pages -Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/jitc-2021-004371
Keywords
COVID-19; tumor microenvironment; translational medical research; immunogenicity; vaccine; head and neck neoplasms
Categories
Funding
- NCI [K99CA240689, 1 R50 CA243707-01A1]
- National Institutes of Health/National Cancer Institute [P30CA016672]
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COVID-19 vaccination may stimulate anticancer immunity and lead to tumor regression.
Vaccination against COVID-19 is critical for immuno-compromised individuals, including patients with cancer. Systemic reactogenicity, a manifestation of the innate immune response to vaccines, occurs in up to 69% of patients following vaccination with RNA-based COVID-19 vaccines. Tumor regression can occur following an intense immune-inflammatory response and novel strategies to treat cancer rely on manipulating the host immune system. Here, we report spontaneous regression of metastatic salivary gland myoepithelial carcinoma in a patient who experienced grade 3 systemic reactogenicity, following vaccination with the mRNA-1273 COVID-19 vaccine. Histological and immunophenotypic inspection of the postvaccination lung biopsy specimens showed a massive inflammatory infiltrate with scant embedded tumor clusters (<5%). Highly multiplexed imaging mass cytometry showed that the postvaccination lung metastasis samples had remarkable immune cell infiltration, including CD4+ T cells, CD8+ T cells, natural killer cells, B cells, and dendritic cells, which contrasted with very low levels of these cells in the prevaccination primary tumor and lung metastasis samples. CT scans obtained 3, 6, and 9 months after the second vaccine dose demonstrated persistent tumor shrinkage (50%, 67%, and 73% reduction, respectively), suggesting that vaccination stimulated anticancer immunity. Insight: This case suggests that the mRNA-1273 COVID-19 vaccine stimulated anticancer immunity and tumor regression.
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