Journal
SCIENCE ADVANCES
Volume 8, Issue 10, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abm7077
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Funding
- General Research Fund of Hong Kong [15304119, 15334316, 12302921]
- Health and Medical Research Fund of the Food and Health Bureau of Hong Kong [05161016, 07183026]
- Environmental and Conservation Fund of the Environment Protection Department of Hong Kong [2020-48]
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In this study, a NIR PL nanoparticle TRZD was synthesized, which exhibited excellent rechargeable NIR PL in vivo and could be used for long-term autofluorescence-free imaging. TRZD could inhibit the tumor growth of glioma models and provide a promising multifunctional nanoparticle for theranostics of brain diseases.
Glioma is the most common malignant primary brain tumor, and the accurate diagnosis of glioma has always been a challenge. Moreover, cerebellar glioma, which is difficult to be detected by magnetic resonance imaging, is not usually diagnosed until after the appearance of clinical symptoms. In this study, TRZD, a near-infrared (NIR) persistent luminescence (PL) nanoparticle with a dual function of imaging and therapy, was synthesized based on ZnGa2O4:Cr3+,Sn4+. TRZD showed excellent rechargeable NIR PL for more than 30 hours in vivo with good tissue penetration for long-term autofluorescence-free imaging. The tumor growth of both the subcutaneous and orthotropic glioma models was significantly inhibited by TRZD. This is the first-time approach using NIR PL nanoprobes for both diagnosis and therapy of glioma. This is also the first-time report of nanotechnology-based diagnosis and therapy of cerebellar gliomas. This study offers a highly promising multifunctional nanoparticle for theranostics of a wide range of brain diseases.
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