An Efficient and Green Synthesis of Tetrahydrobenzo[b]Pyran Derivatives Using [(EMIM)Ac] at Room Temperature

An efficient, expedient, clean and environmental being synthesis of tetrahydrobenzo[b]pyran's twenty derivatives (4 a-t) has been reported via one-pot three component condensation reaction of various benzaldehydes, dimedone and malononitrile in presence of ionic liquid [(EMIM)Ac] as a catalyst at ambient temperature in ethanol. Advantages of these reaction follow the principle of green chemistry, which are operational simplicity, shorter reaction time, and mild reaction conditions with high yield (78-98 %) products.

Automated summary

This study reports an efficient, expedient, clean, and environmentally friendly synthesis of twenty derivatives of tetrahydrobenzo[b]pyran via a one-pot three component condensation reaction. Various benzaldehydes, dimedone, and malononitrile were used as reactants, with an ionic liquid [(EMIM)Ac] used as a catalyst in ethanol at ambient temperature. The advantages of this reaction include the principles of green chemistry, such as simplicity in operation, shorter reaction time, mild reaction conditions, and high yield (78-98%) products.