Diclofenac Imprinted Surface Plasmon Resonance (SPR) Based Sensor

The point of the study is the design of diclofenac (DFC) imprinted SPR sensor to detect DFC. Firstly, pre-complex was formed using DFC and methacrylic acid (MAA). Pre-complex was copolymerized with ethylene glycol dimethacrylate (EGDMA) on the allyl mercaptan functionalized SPR chip. DFC imprinted SPR sensor surface was characterized through atomic force microscopy (AFM), ellipsometry, and contact angle measurements. DFC adsorption kinetics of SPR sensor was examined using DFC aqueous solutions between 0,005 mu g/mL and 10,0 mu g/mL. Langmuir adsorption model was defined as the most fitted model. Competitive adsorption of DFC and carbamazebine was investigated to examine the selectivity. Non-imprinted SPR sensor was formed to investigate imprinting effect.

Automated summary

The study focuses on the design of a diclofenac (DFC) imprinted SPR sensor for DFC detection. The DFC imprinted SPR sensor was successfully prepared by forming a pre-complex and copolymerizing it on the functionalized SPR chip. The surface of the DFC imprinted SPR sensor was characterized using various methods. The results showed that the Langmuir adsorption model was the most suitable for describing the DFC adsorption kinetics, and the selectivity and imprinting effect of the sensor were also demonstrated.