Chitosan-ZnO: An Efficient and Recyclable Polymer Incorporated Hybrid Nanocatalyst to Synthesize Tetrahydrobenzo[b]pyrans and Pyrano[2,3-d]pyrimidinonesunder Microwave Expedition

The innovation of facile, efficient and mild procedures utilizing contemptible, conveniently separable and reusablesolid catalysts that overcome obstacles are invariably in demand. Hence, a straightforward one-pot multicomponent reaction (MCR) and an expedient procedure for the synthesis of pyran annulated heterocycles 5 a-k and 6 l-v is developed using Chitosan-Zinc oxide (CS-ZnO) hybrid nanocatalyst. Use of aqueous medium is one of the major highlight of the present protocol. This protocol renders ease of operation, facile work up and magnified yields (90-95 %) as well as explores the use of modified polymeric substrates in the organic synthesis.

Automated summary

A facile and efficient method for the synthesis of pyran annulated heterocycles using Chitosan-Zinc oxide hybrid nanocatalyst has been developed. This protocol allows for easy operation, convenient work up, and high yields, as well as explores the application of modified polymeric substrates in organic synthesis.