Journal
CHEMISTRYSELECT
Volume 7, Issue 10, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202200174
Keywords
Cycloaddition; DFT modeling; Hammett studies; nitrile oxides; reaction mechanisms
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Funding
- Russian Science Foundation [19-73-10032]
- Russian Science Foundation [19-73-10032] Funding Source: Russian Science Foundation
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This study investigates the synthesis of isoxazoles through cycloaddition reactions and demonstrates the insignificant impact of substituent effects in the addition of benzyl vinyl ether to nitrile oxides. The proposed methodology for synthesizing substituted isoxazolines and isoxazoles shows promising results.
A tangible substituent effect may be perceived as a good feature in developing an organic reaction. This work demonstrates that, on the contrary, a zero-slope Hammet plot should be sought. The synthesis of isoxazoles by consecutive cycloaddition of nitrile oxides to vinyl ethers and alcohols elimination was studied computationally and experimentally. We performed a Hammett study in silico to demonstrate a negligible substituent effect (i. e., broad substrate scope) in the addition of benzyl vinyl ether to nitrile oxides. The modeling was performed at the omega B97X-V/def2-TZVP//PBE0-D4/def2-TZVP+SMD(benzene) level of theory within the RIJCOSX approximation. The experimental evaluation validated the computational model. A versatile methodology for synthesizing substituted isoxazolines and isoxazoles was proposed as the main result. We present this work as a successful example of how quantum chemical modeling can re-boost the classic Hammett approach to the optimization and design of organic synthetic methodologies. We anticipate further Hammett studies in silico, considering the current trend for data-driven chemical research.
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