Chiroptical Enhancement of Chiral Dicarboxylic Acids from Confinement in a Stereodynamic Supramolecular Cage

The fundamental implications that chirality has in science and technology require continuous efforts for the development of fast, economic, and reliable quantitative methods for enantiopurity assessment. Among the different analytical approaches, chiroptical techniques in combination with supramolecular methodologies have shown promising results in terms of both costs and time analysis. In this article, a tris(2-pyridylmethyl)amines (TPMA)-based supramolecular cage is able to amplify the circular dichroism (CD) signal of a series of chiral dicarboxylic acids also in the presence of a complex mixture. This feature has been used to quantify tartaric acid in wines and to discriminate different matrixes using principal component analysis (PCA) of the raw CD data.

Automated summary

The fundamental implications of chirality in science and technology necessitate the development of fast, economic, and reliable quantitative methods for enantiopurity assessment. In this study, a TPMA-based supramolecular cage is able to amplify the CD signal of chiral dicarboxylic acids, enabling the quantification of tartaric acid in wines and discrimination of different matrixes.