Journal
JOURNAL OF BIOTECHNOLOGY
Volume 234, Issue -, Pages 139-157Publisher
ELSEVIER
DOI: 10.1016/j.jbiotec.2016.07.022
Keywords
Flexible feedstock concept; Metabolic engineering; Strain development; Lignocellulosics; Biofuels; Bio-based value-added chemicals; Second generation feedstocks; E. coli; C. glutamicum; Bacillus; Pseudomonas; Yeast; Biorefinery; Hydrolysates; Methanol; CO2
Categories
Funding
- ERASysAPP project MetApp
- ZIM, BMWi [KF2969004SB4]
Ask authors/readers for more resources
Most biotechnological processes are based on glucose that is either present in molasses or generated from starch by enzymatic hydrolysis. At the very high, million-ton scale production volumes, for instance for fermentative production of the biofuel ethanol or of commodity chemicals such as organic acids and amino acids, competing uses of carbon sources e.g. in human and animal nutrition have to be taken into account. Thus, the biotechnological production hosts E. coli, C. glutamicum, pseudomonads, bacilli and Baker's yeast used in these large scale processes have been engineered for efficient utilization of alternative carbon sources. This flexible feedstock concept is central to the use of non-glucose second and third generation feedstocks in the emerging bioeconomy. The metabolic engineering efforts to broaden the substrate scope of E. coli, C. glutamicum, pseudomonads, B. subtilis and yeasts to include non-native carbon sources will be reviewed. Strategies to enable simultaneous consumption of mixtures of native and non-native carbon sources present in biomass hydrolysates will be summarized and a perspective on how to further increase feedstock flexibility for the realization of biorefinery processes will be given. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available