Journal
FOOD BIOSCIENCE
Volume 46, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fbio.2021.101537
Keywords
Mannose; Phosphatidylmannoside; Phosphatidylation; Obesity; Bioavailability
Categories
Funding
- Ocean University of China
- Jiangnan University
- National Natural Science Foundation of China
- National Science Foundation for Post-doctoral Scientists of China [2021M701465]
- National Key R&D Program of China [2018YFC0311201]
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Emerging evidence suggests that dietary D-mannose, enriched naturally in many plants and fruits, show benefits in patients with bacterial urinary tract infection, diabetes, and obesity. However, it is noteworthy that the physiological level of D-mannose in the blood is relatively low. Based on the study that D-mannose could be a safe and beneficial dietary supplement to obese, here phosphatidylation of mannose was proposed as a way to increase the physiological level of D-mannose and enhance the modulatory effect of mannose on obesity.
Emerging evidence suggests that dietary D-mannose, enriched naturally in many plants and fruits, show benefits in patients with bacterial urinary tract infection, diabetes, and obesity. However, it is noteworthy that the physiological level of D-mannose in the blood is relatively low. Based on the study that D-mannose could be a safe and beneficial dietary supplement to obese, here phosphatidylation of mannose was proposed as a way to increase the physiological level of D-mannose and enhance the modulatory effect of mannose on obesity. In this study, phosphatidylmannoside (PtdMan) was synthesized via the approach of phospholipase D mediated transphosphatidylation. In vivo, we show that phosphatidylation of mannose enhanced the physiological level of mannose in blood. The benefits of PtdMan and D-mannose in high-fat diet-induced obesity were then investigated. Compared with D-mannose supplementary, increased physiological level of PtdMan enhanced the expression of fatty acid oxidation-related genes in liver and PPAR. targeted genes in adipose tissue, thus protecting from high-fat diet induced obesity, glucose tolerance, and insulin sensitivity. Together, our findings reveal the possibility that phosphatidylation of mannose could be used as a dietary approach to prevent obesity-associated diseases via its enhanced mannose bioavailability.
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