Targeting the PD-1/PD-L1 axis for cancer treatment: a review on nanotechnology

Although nanomedicines have been in the oncology field for almost three decades with the introduction of doxil, only a few nanomedicine products have reached approval. Can nanotechnology be a realistic tool to reduce the number of hospital beds? At present, several clinically approved anti-PD-1/PD-L1 antibodies or CAR T cell-based therapies are available; however, the immunotherapy field is far from mature. Will immunotherapy be the fourth pillar of cancer treatment? In this review, we summarized the current status of immunotherapy using PD-1/PD-L1-targeting nanocarriers. The knowledge on material science, therapeutic agents and formulation designs could pave the way for high-efficacy treatment outcomes.

Automated summary

Nanomedicine has potential in oncology field, but only a few products have been approved. Immunotherapy, as a new direction in cancer treatment, still requires further development. Using PD-1/PD-L1-targeting nanocarriers can enhance treatment outcomes.