Journal
ROYAL SOCIETY OPEN SCIENCE
Volume 9, Issue 4, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsos.211293
Keywords
cell movements; pattern formation; evolution of complex systems; evo-inspired engineering
Categories
Funding
- Herschel Smith Postdoctoral Fellowship, University of Cambridge and Department of Zoology, University of Oxford [109408/Z/15/Z]
- Henry Dale Fellowship
- Wellcome Trust
- Royal Society
- Cambridge Trust, University of Cambridge
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This study examines the relationship between cell movement and pattern formation during development, aiming to propose research methods that can address both morphogenesis and pattern formation. By reviewing current approaches to studying pattern formation in static and motile cellular environments, the study explores how cell movement can contribute to the generation of patterns.
The mechanisms underpinning the formation of patterned cellular landscapes has been the subject of extensive study as a fundamental problem of developmental biology. In most cases, attention has been given to situations in which cell movements are negligible, allowing researchers to focus on the cell-extrinsic signalling mechanisms, and intrinsic gene regulatory interactions that lead to pattern emergence at the tissue level. However, in many scenarios during development, cells rapidly change their neighbour relationships in order to drive tissue morphogenesis, while also undergoing patterning. To draw attention to the ubiquity of this problem and propose methodologies that will accommodate morphogenesis into the study of pattern formation, we review the current approaches to studying pattern formation in both static and motile cellular environments. We then consider how the cell movements themselves may contribute to the generation of pattern, rather than hinder it, with both a species specific and evolutionary viewpoint.
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