Journal
ENDOCRINE CONNECTIONS
Volume 11, Issue 4, Pages -Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/EC-21-0594
Keywords
vitamin D; vitamin D metabolism; rickets and osteomalacia; calcium and phosphate homeostasis; vitamin D analogs; vitamin D function; 7-dehydrocholesterol; UV light
Categories
Ask authors/readers for more resources
This article provides a unique perspective on the discovery of vitamin D and its deficiency disease, rickets, covering four distinct historical phases and highlighting major developments in the field.
Vitamin D has many physiological functions including upregulation of intestinal calcium and phosphate absorption, mobilization of bone resorption, renal reabsorption of calcium as well as actions on a variety of pleiotropic functions. It is believed that many of the hormonal effects of vitamin D involve a 1,25-dihydroxyvitamin D-3-vitamin D receptor-mediated transcriptional mechanism involving binding to the cellular chromatin and regulating hundreds of genes in many tissues. This comprehensive historical review provides a unique perspective of the many steps of the discovery of vitamin D and its deficiency disease, rickets, stretching from 1650 until the present. The overview is divided into four distinct historical phases which cover the major developments in the field and in the process highlighting the: (a) first recognition of rickets or vitamin D deficiency; (b) discovery of the nutritional factor, vitamin D and its chemical structure; (c) elucidation of vitamin D metabolites including the hormonal form, 1,25-dihydroxyvitamin D-3; (d) delineation of the vitamin D cellular machinery, functions and vitamin D-related diseases which focused on understanding the mechanism of action of vitamin D in its many target cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available